Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Lipid signalling"”.
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Hypoxia, Lipid Signalling and Tissue Metabolism in Obesity-Related Metabolic Disease
… and progression of metabolic dysregulation. As lipid metabolism is highly dependent on oxygen tension, this work aimed to investigate the links between hypoxia and altered tissue metabolism accompanying the progression of obesity-related metabolic disease, with a particular focus on lipid …
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Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscle
… However, the interaction between ER stress, lipid metabolism and T2DM remains poorly understood. This thesis uses lipidomic tools to investigate skeletal muscle ER stress in cell culture and animal models. Chronic palmitate treatment of both mouse C2C12 and human primary myotubes induced ER …
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Suppression and activation of lipid signalling in cancer : tumour suppressor PTEN and oncogenic sphingosine kinase
… tumour suppressor gene in cancer. It is a lipid and protein phosphatase that negatively regulates the well-known pro-proliferative and anti-apoptotic phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway to modulate cell proliferation, cell cycle progression and cell survival. …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
… system is an important endogenous lipid signalling system known to mediate glucose and lipid metabolism, inflammation and energy storage. Specifically, diabetes mellitus and obesity induces alterations in the expression of cannabinoid receptor 1 (CB1), cannabinoid receptor 2 (CB2) …
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Oleoylethanolamide and palmitoylethanolamide synergize with IFNβ to potentiate apoptosis and PD-L1 induction in SH-SY5Y neuroblastoma cells
… (PEA) are endogenous bioactive lipids that act as selective agonists of the peroxisome proliferator-activated receptor α (PPARα), a nuclear receptor implicated in lipid metabolism, inflammation, and cancer biology. While their anti-tumour potential has been suggested in various …
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Syncytiotrophoblast formation is influenced by genes involved in lipid biology
… the process of trophoblast fusion involving a lipid- signalling event and dynamic membrane rearrangement. Defects altering the structure and abundance of SynT cells in the labyrinth are enriched in embryonic lethal mouse mutants. From these findings, we are interested in understanding the …
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The Role of Autotaxin in Cancer
… and tumour cells and our data show that ATX signalling can drive tumour cell growth in an autocrine manner. In contrast, in PDAC the TME primarily expresses ATX. The cell lines, PANC-1 and MIA PaCa-2 and the cancer associated fibroblast (CAF) derived cell line, 0082T, were used as a model to …
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A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids
… PI3Ks are a family (α, β, δ and γ) of ubiquitous lipid kinases that can be activated by cell surface receptors to 3-phosphorylate PI(4,5)P2 (phosphatidylinositol(4,5)-bisphosphate) and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of effector …