Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"Lipid membranes"”.
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Lipid-protein interactions in lipid membranes
In dieser Arbeit werden Lipid-Protein-Wechselwirkungen und lipidvermittelte Protein-Protein-Wechselwirkungen mittels Monte-Carlo-Simulationen eines generischen vergröberten Modells für Lipiddoppelschichten mit hydrophoben Einschlüssen untersucht. Die Ergebnisse werden mit den Vorhersagen zweier …
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Quantifying passive drug transport across lipid membranes
… the permeability coefficient of drugs crossing lipid membranes. Lipid vesicles are used as model systems and drug molecules are tracked directly using their autofluorescence in the ultraviolet. The permeability coefficient of the drug is inferred by studying the increase in drug autofluorescence …
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Interaction of amphiphilic nanoparticles with structurally perturbed lipid membranes
… the interactions between nanoparticles and lipid membranes is important for applications such as drug delivery and membrane-protein mimetics. Perturbations such as area asymmetry and lateral tension affect these interactions by inducing various structural changes to the membranes. We use …
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Relating phase separation and thickness mismatch in model lipid membranes.
Membrane lipids can spontaneously undergo a process called phase separation wherein they organize into domains with different compositions. Phase separation has been proposed as a mechanism in the formation of heterogeneous lipid regions (e.g. rafts) in cell membranes. The activity and partitioning …
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Molecular Dynamics Simulations In The Study Of Biological Lipid Membranes
… important macroscopic properties of proteins or membranes (composition, organization, folding, etc.) derived from experiments to properties at the molecular level arising from interactions between individual amino acids or lipids. The simulations in this thesis investigate the dynamics of lipid …
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Uncovering Structure-Property Relations in Biomimetic Lipid Membranes with Molecular Additives
The lipid bilayer, the fundamental structure of cell membranes, exemplifies a highly adaptable molecular assembly with characteristics that have been fine-tuned through evolution to meet the diverse functional needs of cells. These bilayers must strike a delicate balance: they need to be …
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Measurements and Modeling of the Failure Pressure of Bilayer Lipid Membranes
Bilayer lipid membranes (BLMs) are formed from phospholipid molecules which self-assemble into a lipid bilayer with 4 to 9 nm thickness when submerged in an aqueous solution. This is due to their amphiphilic nature, meaning that one part of the molecule is hydrophilic, or attracted to water, and …
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Adjuvant Interactions with Lipid Membranes and Their Effect on Cellular Immune Responses
… membrane. Although few have considered how lipid-mediated interactions contribute to adjuvanticity, previous studies suggested aluminum-based adjuvants (ABAs) have high affinity for sphingomyelin and cholesterol, which allowed them to activate dendritic cells exclusively through lipid …
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Study of the enhancement effect of cyclopentadecanolide on protein permeation through lipid membranes
… a permeation enhancer in protein release through lipid bilayer membranes. We successfully designed a novel in-vitro membrane permeability model using liposomes and performed a series of transmembrane protein release experiments. These were carried out under a wide range of conditions in the …
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Interaction of amphiphilic gold nanoparticles with lipid membranes and their application to cancer radiotherapy
… combination of striped gold nanoparticles with lipid vesicles of diameter < 200 nm in order to concentrate their delivery and couple their delivery to the delivery of pharmaceuticals. Mechanisms of penetration of striped gold nanoparticles into live cell membranes via non-endocytic pathways was …
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Structural Elucidation of the Interaction Between Neurodegenerative Disease-Related Tau Protein with Model Lipid Membranes
… to heterogeneous interactions, including with lipid membranes. Lipids have been found in NFTs, anionic lipid vesicles induced aggregation of the microtubule binding domain of tau, and other protein aggregates induced ion permeability in cells. This evidence prompted our investigation of ta's …
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Influence Of Cholesterol And Bilayer Asymmetry On Membrane Protein Distribution In Polymer-Tethered Raft-Mimicking Lipid Membranes
<p>It is now widely recognized that lipid rafts, which are membrane domains enriched in cholesterol (CHOL) and sphingolipids (SL), play a significant functional role in the plasma membrane. Raft domains particularly affect membrane functionality by causing sequestering of membrane proteins. …
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Ion binding to polymers and lipid membranes in aqueous solutions : Ionenbindung an Polymeren und Lipidmembranen in wässrigen Lösungen
… Untersuchung der Ionenbindung an Polymeren und Lipidmembranen in wässrigen Lösungen. Im ersten Teil dieser Arbeit wurde der Einfluss verschiedener anorganischer Salze und Polyelektrolyte auf die Struktur des Wassers mit Hilfe Isothermer Mikrotitrationskalorimetrie (ITC) erforscht. Die …
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Electrostatic control of Cu, Zn superoxide dismutase aggregation in Amyotrophic Lateral Sclerosis : from lysine modification to interaction with lipid membranes.
… of SOD1 is mediated by its interaction with lipid membranes.
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Passive transport through biological membranes
… into cells via cellular walls made of lipid membranes. Through the wall the cell needs to transport nutrients, waste, genetic information and signaling molecules. The cell achieves this task via passive and active transport. In this thesis we focus on passive transport processes. In …
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Protein mimetic nanoparticles
… have been shown to spontaneously fuse with lipid bilayers through a non-endocytic mechanism that generates minimal membrane perturbation. The membrane translocation capability of these nanoparticles makes them attractive candidates for engineering clinical applications that operate on a …
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Protein-lipid interactions in molecular pathways of Parkinson’s and Alzheimer’s diseases
… in AD and PD through aberrant interactions with lipid membranes. Despite current significant effort, the link between αS-/Aβ42-membrane interactions and disease mechanisms remains elusive. In this work, I applied a set of bulk and microfluidic assays to address this problem by quantifying …
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