Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Lipid domains"”.
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Influence of protein and lipid domains on the structure, fluidity and phase behavior of lipid bilayer membranes
The lipid bilayer forms the basic structure of the cell membrane, which is a heterogeneous matrix of proteins and lipids that provides a barrier between the interior of a cell and its outside environment. Protein and lipid domains in cell membranes can facilitate receptor localization, stabilize …
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Structure and Application of Photosensitive Self-assembled Pseudoisocyanine J-aggregates on Membrane Surfaces
… were found to form on top of the heterogeneous lipid domains in a phospholipid bilayer. This behaviour is limited to a few headgroup chemistries and lateral packing motifs, allowing one to control aggregation via a combination of these two factors. These aggregates are low-dimensional and …
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Regulation of receptor signaling and membrane trafficking by beta1,6-branched n-glycans and caveolin-1/cholesterol membrane domain organization
… N-glycans and other regulators, such as membrane lipid domains, in the control of signaling pathways remains poorly understood. My thesis therefore focuses on how N-glycans and membrane lipid domains oppose and/or work together at different cellular levels to regulate various processes such as …
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Probing the formation of mammalian cell lipid microdomains with nanometer-scale imaging secondary ion mass spectrometry
… a more heterogenous environment of proteins and lipids. The complexity of living cells have made for difficulties in obtaining a complete understanding of the plasma membrane, especially that of the sphingolipids’ organization. The recent application of imaging mass spectrometry to biological …
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Uncovering Structure-Property Relations in Biomimetic Lipid Membranes with Molecular Additives
The lipid bilayer, the fundamental structure of cell membranes, exemplifies a highly adaptable molecular assembly with characteristics that have been fine-tuned through evolution to meet the diverse functional needs of cells. These bilayers must strike a delicate balance: they need to be …
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The modulation of cytochrome P450 activities by their membrane lipid environment
… their activities can be modulated. The membrane lipid environment of CYP isoforms has proved to be an essential component for their optimal activities and consequently investigations into this aspect of modulation are fundamental to many areas of research. The work described in this thesis …
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Adjuvant Interactions with Lipid Membranes and Their Effect on Cellular Immune Responses
… membrane. Although few have considered how lipid-mediated interactions contribute to adjuvanticity, previous studies suggested aluminum-based adjuvants (ABAs) have high affinity for sphingomyelin and cholesterol, which allowed them to activate dendritic cells exclusively through lipid …
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Lattice Boltzmann method for integrating the Bloch equation in muscle fibers and microvessels
… properties of directional water diffusion and lipid concentration in the human muscle. Strong correlations have also been found between overall fitness and MRI measurements related to the transport of water inside the muscle fibers. In addition to water diffusion within the muscle, MR imaging …
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Formation of membrane domains during the activation of protein kinase C
The relationship between lipid domains and protein kinase C activity was studied via the direct visualization and quantitation of domains by fluorescence digital imaging microscopy. The lateral organization of protein kinase C, its substrate (the MARCKS peptide) and its three activators …
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DNA-based Artificial Mimics of Cell-surface Machinery
… a range of elementary molecular components, from lipids to polymers and proteins, yet artificial cellular membranes are usually passive enclosures lacking the diverse functionalities hosted by their biological counterparts. DNA nanotechnology has emerged as a prime route for biomimicry given its …
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Neutron scattering studies of water diffusion near the interface of model cell membranes
… depend on the interactions between peptide-lipid domains and the hydrating water. Therefore, the dynamics of the membrane-associated water and its interaction with embedded proteins remain some of the most fundamental issues in biological physics today. Single-supported lipid bilayers …
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Protein-lipid interactions in raft-exhibiting membranes probed by combined AFM and FCS
… far from being an inert assembly of protein and lipids which separates cells from the surrounding environment. A multitude of biological processes, ranging from active transport of ions into and out of the cell, to the immune response, are regulated at the level of the plasma membrane. The …
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STRUCTURAL INVESTIGATION OF EXTRACELLULAR VESICLES AND THEIR INTERACTION WITH BIOMIMETIC INTERFACES
… including their common biomarkers, protein, and lipid profiles, to exploit them for therapeutic or diagnostic purposes. Here, an alternative novel physical approach to study EVs’ properties is carried by inspecting the EVs’ physical characteristics and connecting them to their activity. In the …
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Structural study of lipid bicontinuous cubic phases for cellular delivery
Lipid bicontinuous cubic phase is fundamentally interesting phase. Initially it is considered as an intermediate structure between lamellar and hexagonal phases due to its small phase space and complicated structure. With the development of structure characterization technologies, especially X-ray …
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Investigating spatial distribution and dynamics of membrane proteins in polymer-tethered lipid bilayer systems using single molecule-sensitive imaging techniques
… complex supramolecular assemblies comprised of lipids and membrane proteins. Both types of membrane constituents are organized in highly dynamic patches with profound impact on membrane functionality, illustrating the functional importance of plasma membrane fluidity. Exemplary, dynamic processes …