Global ETD Search
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Showing 1 to 6 of 6 for “"Lipid asymmetry"”.
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Uncovering Mechanisms of Cell Envelope Integrity and Nutrient Acquisition in Acinetobacter baumannii
… entry of essential nutrients. The maintenance of lipid asymmetry (Mla) system is the primary homeostatic mechanism in Gram-negative bacteria to maintain lipid asymmetry by removing mislocalized phospholipids from the OM. In A. baumannii and other bacteria, loss of the Mla system results in …
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Lipid Composition and Configuration Drive Biophysical Properties of The Mammalian Plasma Membrane
<p>In the 1970s, it was established that phospholipid (PL) classes are asymmetrically distributed across the (PM) leaflets. Recapitulating strategies coupled with newly developed, high-resolution shotgun lipidomics, our lab confirmed PL class asymmetry and surprisingly measured the endoplasmic …
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Linking Architecture and Function of Endoplasmic Reticulum - Plasma Membrane Contact Sites
… and thereby promote cellular functions such as lipid metabolism, signalling and organelle biogenesis. The formation of cortical endoplasmic reticulum (cER) - plasma membrane (PM) contacts in budding yeast cells is mediated by a set of six conserved proteins. By combining correlative light and …
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Regulation and functional significance of ATP binding cassette transporters in human placenta
… with transient loss of plasma membrane lipid asymmetry. Finally, expression of BCRP/ABCG2 (and 9 other genes) was studied in 50 placentas from normal pregnancy and pregnancies complicated with fetal growth restriction (FGR). A marked reduction of BCRP/ABCG2 and MDR1/ABCB1 expression was …
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Consequences of Asymmetric Environment on the Mechanics of Lipid Bilayer
Lipid membranes are selective barriers that encapsulate cellular components and define the identity of organelles. A fundamental feature of membranes is an asymmetric distribution of lipids and proteins across them. While a basic level of asymmetry is maintained at all times, local and transient …
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Functional Asymmetry of The Immune Cell Plasma Membrane
… cells maintain a distinct disparity in lipid composition between the two leaflets of the bilayer of the plasma membrane. This compositional asymmetry is most prominent for phosphatidylserine (PS), a negatively charged lipid that is found almost exclusively on the cytoplasmic (inner) …