Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Lipid Vesicles"”.
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Microfluidic Transport Studies on Lipid Vesicles
… role in the uptake and efflux of molecules. Lipid bilayers are therefore an important object of research in many fields of science, such as biophysics, pharmacology and synthetic biology. In this thesis, we develop new microfluidic methods that allow us to study the laws that govern the …
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Shape dynamics of anisotropic lipid vesicles using automated flow control
Open Restriction set for Item 121041 on 2022-01-25T16:14:39Z with date null by eliasbh2@illinois.edu.
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Multivalent Programmable Interactions Between Lipid Vesicles: Towards Responsive Soft Materials
Lipid membranes and lipid vesicles have been studied extensively in the last 50 years in order to characterise their biological, chemical and physical properties. Such work is of interest from a fundamental biological perspective, but also due to the applications that their biocompatibility …
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Cellular mimics within lipid vesicles and in thermal out-of-equilibrium chambers
… that do not rely on compartments made from lipid membranes.
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Electrofusion of Escherichia coli with Giant Lipid Vesicles and the Compaction of Escherichia coli Nucleoid
The fusion of lipid membranes is a key step in genetic manipulation technologies, and a ubiquitous phenomenon observed in many aspects of cellular activities. To date, various methods have been developed for artificially inducing the fusion of biological and synthetic lipid membranes/vesicles to …
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Light-triggered rupture and magnetically driven transport of lipid vesicles for controlled release and directed delivery of therapeutics
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Dynamics and Structures of Phospholipid Assemblies
… thesis studies structures and dynamics of phospholipids vesicles and their interactions with nanoparticles and peptides, with a focus on the following problems: (1) Single-vesicle dynamics for new colloidal physics. Phospholipids vesicles are stabilized by physically adsorbed nanoparticles, and …
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Interaction of amphiphilic gold nanoparticles with lipid membranes and their application to cancer radiotherapy
… combination of striped gold nanoparticles with lipid vesicles of diameter < 200 nm in order to concentrate their delivery and couple their delivery to the delivery of pharmaceuticals. Mechanisms of penetration of striped gold nanoparticles into live cell membranes via non-endocytic pathways was …
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Self-assembled Supramolecular Structures Of Chiral Phospholipids: Structure, Mechanical Properties And Patterning
Lipid molecule is well known natural building block to form different supramolecular structures with specific shape, size and functionality. In my thesis work, I have used DC8,9PC 1,2-bis(tricosa-10,12-dinoyl)-sn-glycero-3-phosphocholine), a type of chiral lipid to form the vesicles, tubules and …
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Ultrasonic Absorption in Solutions of Proteins and Peptides and in Suspensions of Liposomes
… and equeous suspensions of large unilamellar lipid vesicles (LUV) of various compositions. Measurements were performed at temperatures between 20(DEGREES)C and 50(DEGREES)C in the frequency range 0.5 MHz to 7 MHz.
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An assembly model for the autophagy initiation complex
… complex (AIC), which binds high curvature lipid vesicles and is thought to catalyze their fusion to initiate autophagosome biogenesis. In chapters 1-4 of this work, I review what is currently known about different steps of the mechanism of AIC formation, its interactions with lipid vesicles …
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Understanding the membrane biophysics of alpha-Synuclein and its role in membrane curvature induction and structural remodeling
… membrane, whereas in vitro studies of small lipid vesicles and aSyn demonstrate an inhibition of vesicle fusion. In addition, numerous biophysical studies have identified potential curvature sensing and curvature inducing characteristics for aSyn, however the mechanism behind these processes …
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Examining Post-Translational Modifications In Alpha-Synuclein Through Semi-Synthesis And Single Molecule Spectroscopy
… vesicle trafficking through interactions with lipid surfaces. The pathological, fibrillar aggregates of αS are implicated in a class of neurodegenerative disorders including Parkinson’s disease. A variety of post-translational modifications (PTMs) are known or hypothesized to affect both the …
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On the Rheology of Soft Cellular Materials, An Experimental Investigation of the Microstructure and Rheology of a Novel Tissue-Mimic Material
… made from functionalised giant unilamellar lipid vesicles, in which inter-particle adhesion and membrane tension can be varied experimentally by controlling the functionalisation and sample temperature. This thesis reports on contributions made in three areas. The first describes how 3D …
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Investigating lipid corona formation onto polystyrene nanoparticles through fluorescence correlation spectroscopy
… the cell membrane, which is composed of phospholipid bilayer. Fluorescence correlation spectroscopy (FCS) is a promising tool that can be used to probe nanoparticle-cell interactions. FCS experiments focusing on exposure of lipid vesicles to different polystyrene nanoparticles indicate possible …
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Development of a Fluorescence Lifetime Based Method to Detect and Analyze Single Molecule Reactions in Solution
… with a FRET pair, and encapsulated within 100nm lipid vesicles. A toolbox of analysis techniques was developed for PTA, and was used to quantitatively describe the transitions and fluctuations of the conformation of calmodulin. Analysis was done in a model-free manner, and also by applying known …
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Seeing the unseen dynamics in soft matter
… First, mechanical responses of both polymer and lipid vesicles were investigated by watching their shape transformations under environmental variations, mostly under osmotic shocks, which emitted new prospects on membrane elasticity, instability and kinetics. Furthermore, with statistical …
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Influence of protein and lipid domains on the structure, fluidity and phase behavior of lipid bilayer membranes
The lipid bilayer forms the basic structure of the cell membrane, which is a heterogeneous matrix of proteins and lipids that provides a barrier between the interior of a cell and its outside environment. Protein and lipid domains in cell membranes can facilitate receptor localization, stabilize …
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Stabilization of liposomal functional anchors by cross-linkable lipids
… to stabilize a class of liposomes in which lipid vesicles are modified post- fabrication through surface adsorption and anchoring. We hypothesized that the sequential adsorption of functional units followed by covalent cross-linking of the liposome would provide enhanced stability in the …
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An interdisciplinary approach to studying mechanistic, structural and toxic features of protein aggregates associated with neurodegenerative disorders.
… that enables the study of aggregate induced lipid bilayer permeability, possibly the most general mechanism of protein aggregate toxicity. Surface-tethered lipid vesicles functioning as optochemical probes sensitive to membrane integrity are imaged using total internal reflection microscopy. …
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