Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Lipid Regulation"”.
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Novel lipid regulation of vacuolar fusion in saccharomyces cerevisiae
… relatively little is known about the role lipid regulation plays in membrane fusion. It has been well established that enrichment of specific regulatory lipids leads to recruitment and activation of the fusion machinery. Additionally these lipids are modified by specific kinases, …
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Lipid Regulation as a Critical Factor in the Development of Alzheimer's Disease
… of a larger, systemic disease affecting the regulation of lipids, including cholesterol. In addition to assigning a physiological function for APP and Aβ generation, my hypothesis suggests that lipid dysregulation would likely occur early in the disease process, making it an ideal target for …
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Estrogen Depletion Effects on Myelination and Lipid Regulation within the Central Nervous System
… astrocytes, microglia, OPCs, and myelin levels. Lipidomic analysis was performed using tandem mass spectrometry to measure how phospholipids and sterols were altered with estrogen depletion in demyelination in the CNS. Thus, we have successfully combined ovariectomy surgery and a mouse model of …
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Metabolic lipid regulation during developmental stress : fatty acid dynamics in fasting northern elephant seals.
… NES age classes and expands current knowledge of lipid utilization in a mammal accustomed to a LCFA-rich diet.
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Identification of estrogen-regulated genes in the cerebral cortex and development of a novel method to detect methylated DNA
… cell adhesion, apoptosis, development, lipid regulation, transcriptional control, and signaling pathways. The gene expression changes in both normoxic and hypoxic conditions reveal the numerous and diverse processes that are important for understanding neuroprotection and may be helpful …
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HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
… role of genotypes in core-mediated differential regulation of lipid metabolism. Prior studies described the lipid induction by HCV infection or ectopic expression of core derived from gt1a and 3a HCV qualitatively. The goal of this thesis is to define the gt1a and 3a HCV core-mediated lipid …
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HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
… role of genotypes in core-mediated differential regulation of lipid metabolism. Prior studies described the lipid induction by HCV infection or ectopic expression of core derived from gt1a and 3a HCV qualitatively. The goal of this thesis is to define the gt1a and 3a HCV core-mediated lipid …
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Exploring chemical communication and chemical heterogeneity in biological systems with mass spectrometry imaging
… in all biological systems—whether caused by lipid regulation and expression between individual mammalian single cells or by dynamic chemical communication in bacterial communities. Mass spectrometry imaging (MSI) is an untargeted and unlabeled analytical tool that enables us to look at …
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Nutrient regulation by an omnivore and the effects on performance and distribution
… omnivores must maintain some level of nutrient regulation. To explore the effects of nutrient regulation by an omnivore, I used a salt marsh katydid, Conocephalus spartinae. To first address the ability of Conocephalus to perform on a wide range of diets and to regulate their nutritional intake, …
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MAPK9: Ein neuer Regulator des Triglyzerid-Stoffwechsels, entdeckt durch siRNA Screening
Lipid homeostasis is an essential factor for proper function both at the level of a cell and of an organism. Dysregulation of this process is responsible for some of the major health concerns of our societies such as obesity and atherosclerosis. Considering the wide variety of lipids and the high …
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Mechanism and Function of TrkB.T1 Astrocyte Expression
… highlighted disruptions in metabolism and lipid regulation, particularly cholesterol transport, suggesting potential implications for synapse formation. We observed dysregulated spine density in the motor and somatosensory cortices from TrkB.T1-deficient astrocytes relative to control …
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Intergenerational effects of early life programming: the role of glucocorticoids and maternal obesity
… altered expression of hepatic genes important in lipid regulation and metabolism. More striking changes were seen in the F2 generation in which there was an effect of paternal exposure to maternal obesity to decrease birth weight. There were also parent of origin effects on organ weights and …
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The regulation of yeast homotypic vacuole fusion by phosphatidic acid and diacylglycerol
… well established, however the roles regulatory lipids at the membrane play are still unclear. Many specific regulatory lipids localize to the site of fusing vacuoles termed the “vertex ring” implying an important role for them throughout the fusion process. It has been shown that the minimal …