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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 71 for “"Lipid Nanoparticles"”.
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Development of Afatinib lipid nanoparticles targeting non small cell lung cancer
… for AFT were developed, with different ratios of lipid to AFT, using a film hydration method. The obtained liposomes had a small particle size of less than 50 nm with a low polydispersibilty index and acceptable zeta potential. The highest Encapsulation Efficiency (EE%) of AFT reached 43.20%, …
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Developing photoresponsive lipid nanoparticles for the triggered release of small molecules
… examine numerous photo responsive drug delivery nanoparticles containing two different first-generation (1G) donor-acceptor Stenhouse adduct (DASA) molecules, DOPC, DLPC, cholesterol and lauric acid. The DASA isomerizes upon visible light irradiation, thereby increasing membrane permeability …
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Development of solid lipid nanoparticles for sustained release of anticancer agents
A brief introduction to solid lipid nanoparticles (SLN) is provided and the reasoning behind the use of SLN over other colloidal carriers, such as emulsions and liposomes, are discussed. SLN has many advantageous such as controlled drug release, non-biotoxicity of the carrier, increased …
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Synergistically active curcumin resveratrol solid lipid nanoparticles for treatment of melanoma
… and resveratrol. In this context, topical solid lipid nanoparticles were introduced as a drug carrier to enhance the skin penetration of the aforementioned polyphenols and exploit their anti-cancer activity. Small, negatively charged curcumin and resveratrol loaded SLNs (Cur-Res SLNs) with a mean …
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Optimization and analysis of lipid nanoparticles for in vivo mRNA delivery
… a safe and effective delivery vector. Lipid nanoparticles (LNPs) have shown considerable promise for the delivery of small interfering RNAs (siRNA) to the liver but their utility as agents for mRNA delivery have only been recently investigated. New delivery materials for mRNA delivery …
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Design and Development of Solid Lipid Nanoparticles for Ocular Delivery of Acyclovir
… acyclovir (ACV) by incorporating it into solid lipid nanoparticles (SLNs) and nano-structured lipid carriers (NLCs). Methods: SLNs and NLCs were prepared by a hot microemulsion technique. Nanoparticles were characterised by laser diffraction size measurements, zeta potential, scanning electron …
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Development of polymer - lipid nanoparticles for potent mRNA delivery to the lung
… transport into cellular cytoplasm in vivo. Many lipid nanoparticles originally designed to deliver short interfering RNA (siRNA) have been successfully repurposed to deliver mRNA, although their application is limited mainly to the liver. Thus, there is a continued need for the development of new …
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Systematic Design, Synthesis, and Evaluation of Ionizable Lipids for Lipid Nanoparticles Delivering mRNA
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Design and synthesis of ionisable amino-polyester lipid nanoparticles for extrahepatic RNA delivery
… replacement and regenerative medicine. Polymeric nanoparticles offer a promising route for extrahepatic mRNA delivery, although challenges such as polydispersity and biocompatibility have hindered their clinical translation. Controlled polymerisation methods, such as ring-opening polymerisation …
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Engineering Lipid Nanoparticles for sIRNA Delivery to Silence Identified Targest in Cancer Cells
… the foundation for the future development of a lipid-polymer nanoparticle (LPNP) system.</p> <p>Chapter 1 provides a comprehensive overview of the breast cancer treatment landscape, discussing established therapies like hormone therapy and HER family receptor inhibitors, as well as emerging and …
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RGD-targeted Solid Lipid Nanoparticles Containing Asiatic Acid for the Treatment of Cancer
… AA was incorporated into RGD-containing solid lipid nanoparticles (SLNs) after optimisation of the SLN preparation comprised of glyceryl monostearate, glyceryl distearate and glyceryl tristearate lipids and subsequent characterisation on their physicochemical properties. The targeting ability …
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Re-engineering of Dendrimer-Based Lipid Nanoparticles for Efficient and Precise HDR-Mediated Gene Editing
… details the development of dendrimer-based lipid nanoparticles (dLNPs) for the encapsulation and delivery of multiple nucleic acids necessary for HDR: Cas9 mRNA, sgRNA, and a donor DNA template containing the correct nucleic acid sequence, as well as the optimization of intra-particle …
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Delivery of sting agonist using lipid nanoparticles and discovery of anti-TIGIT peptides for cancer therapy
… deliver a STING agonist into a cold tumor using lipid nanoparticles. This delivery is intended to provoke an immune response that leads to the elimination of tumor cells. STING pathway agonism has shown promise in innate immune signaling to tune the tumor microenvironment toward an immunogenic …
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Drug-Polymer and Drug-Lipid Miscibility for the Development of Amorphous Solid Dispersions and Solid Lipid Nanoparticles
… FLT amorphous solid dispersions (SDs) and solid lipid nanoparticles (SLNs) were prepared to overcome limited solubility. Investigation of drug-polymer and drug-lipid miscibility was carried out to enhance drug performance by assessing solubility and particle size. Miscibility was then correlated …
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Lipid Nanoparticles as Tools for the Administration of Active Natural Products Aimed to the Treatment of Nervous System Disorders
… solvent evaporation method obtaining spherical nanoparticles having a particle size suitable for parenteral administration (<200 nm). Nanoparticles showed a good stability for six months at room temperature, as confirmed by Turbiscan Technology. Furthermore, the obtained data showed that the …
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Development of a saposin A based native-like phospholipid bilayer system for NMR studies
… The recently developed saposin-A (SapA) based lipid nanoparticle system seems to be advantageous over existing membrane mimetic system. It provides a native-like lipid bilayer, high incorporation yield and more importantly size adaptability. SapA lipid nanoparticles have been applied to …
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Lipid & surfactant based systems for improved delivery of poorly soluble APIs
… and low plasma levels post oral administration. Lipids comprise of fatty acids and their derivatives and are considered a biocompatible option for drug delivery. In the studies discussed in following chapters, lipid based drug delivery systems (LBDDS) have been utilized in improving the handling, …
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ENGINEERING LIPID AND HYBRID NANOVECTORS FOR TARGETED GENE DELIVERY TO MACROPHAGE SUBPOPULATIONS
… materials are complexed with a polycation or a lipid, followed by the addition of a lipid or a polymer to ameliorate the cellular toxicity, modulate cellular uptake and/or improve the transfection efficiency of the resulting nanovectors (Chapter 1). The experimental part of this thesis is …
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Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye
Lipid based systems and topical ocular inserts of various drugs were developed for the intervention/treatment of posterior segment ocular complications. Indomethacin (IN) was developed into solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Effect of surface …
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