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Showing 1 to 3 of 3 for “"Lipid Kinase Assay"”.
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Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
Phosphoinositide 3-kinases (PI3K) are major regulators of many cellular functions, and its hyperactivation is a major target for anticancer drug discovery. PI3Kα is the isoform most implicated in cancer, and this thesis is dedicated to investigating how specific protein-ligand interactions in the …
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The Development of a Time-Resolved, Vesicle-Based, Fluorescence Assay for the Activity of the Lipid Kinase Pik1
Pik1 is a yeast phosphatidylinositol-4 kinase that is critical for vesicular traffic to the plasma membrane and endosomes from the trans-Golgi (1, 2). Pik1 is a soluble enzyme, and the small myristoylated, Ca2+ binding, EF hand protein, Frequenin (Frq1) facilitates its membrane localization (3). It …
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Mechanistic Investigation of Genotype-Phenotype Correlations in PIK3R1-Related Diseases
… subunits of Class IA phosphoinositide 3-kinases (PI3Ks). These regulatory subunits heterodimerise with one of three catalytic subunit isoforms, namely p110$\alpha$, p110$\beta$, or p110$\delta$. Class IA PI3Ks are critical enzymes involved in fundamental metabolic and mitogenic signalling …