Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Lipid Homeostasis"”.
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Autophagy and Lipid Homeostasis in C. elegans
… liver disease. Therefore it is no surprise that lipid-related metabolic disorders have become a significant burden to our healthcare system. In recent years, the conserved cellular recycling process of autophagy has been linked to several lipid-related metabolic disorders, including insulin …
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Influence of mitochondrial and nuclear genomic dysfunction on lipid homeostasis in lipidemic diseases
… by mitochondrial dysfunction and dysregulated lipid metabolism. DDD and dyslipidaemia are both highly prevalent non-communicable diseases (NCDs) in South African urban populations, with rising incidence rates. Despite these NCDs high prevalence, research in African populations often focuses on …
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Brain Lipid Homeostasis as a Primary Function of Sleep: Insights from Drosophila melanogaster
… for glial support of neuronal health through lipid homeostasis as a primary function of sleep using adult Drosophila melanogaster as a model. In Chapter 1, I highlight the links between lipid metabolism and sleep by presenting previous studies in glia and in invertebrate model systems. I …
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The role of macrophage intracellular lipid partitioning in glucose and lipid homeostasis during obesity
… tissue (WAT), the organ designed for safe lipid storage, as a key factor in the development of MetS and CVD. At a genetically-defined stage of the aberrant WAT expansion that occurs during obesity, adipocytes undergo a functional failure, resulting in an impaired control of serum free fatty …
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The role of Integrin-Linked Kinase in regulating glucose and lipid homeostasis in adipose tissue
… expression, potentially indicative of reduced lipid uptake. Finally, the deletion of ILK in 3T3-L1 cells resulted in a decrease in PPARγ and C/EBPα and a failure to differentiate into mature adipocytes. <br/><br/>These data demonstrate that the pathogenic overexpression of ILK in adipose tissue …
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A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
… KLF6 inhibition led to the deregulation of lipid homeostasis pathways in ccRCC cells. A dual KLF6 role was identified in modulating lipid homeostasis pathways in ccRCC: First, KLF6 directly regulates the expression of several important lipid homeostasis genes. Second, KLF6 promotes PDGFB …
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The APOE Pathway as a Modulator of Amyloid Pathology in Alzheimer's Disease Models
… sporadic AD, with apoE protein crucial for brain lipid transport. ATP-binding cassette subfamily A member 1 (ABCA1), another risk gene, loads lipids onto apoE, highlighting the importance of lipid homeostasis in AD. MicroRNA-33 regulates the expression of ABCA1 and apoE lipidation, although its …
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Epigenomic and Transcriptional Regulation of Hepatic Metabolism by REV-ERB and Hdac3
… colocalizes with HDAC3 near genes regulating lipid metabolism, and deletion of HDAC3 or Rev-erbα in mouse liver causes hepatic steatosis. Thus, genomic recruitment of HDAC3 by REV-ERBα directs a circadian rhythm of histone acetylation and gene expression required for normal hepatic lipid …
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The Biogenesis and Homeostasis of the Shigella flexneri Cell Envelope
… of three distinct domains including the lipid A endotoxin, a core oligosaccharide, and a highly variable distal polysaccharide termed the O antigen (Oag). Importantly, S. flexneri expresses two distinct variants of the Oag polysaccharide: short-Oag (S-Oag; 10-17 repeat units) and very …
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THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… inflammation, insulin resistance, and ectopic lipid accumulation. Research has implicated synthetic (i.e., Bisdehydrodoisynolic acid, BDDA) and natural (i.e., genistein and daidzein) xenoestrogens in the protection against obesity-related pathologies. Bisdehydrodoisynolic acid (BDDA) reduced …
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MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
… role in cancer, we identified a deregulation of lipid-related enzymes. Given that metastatic melanoma is characterized by high metabolic plasticity, we explored the novel role of BACE2 in regulating lipid homeostasis and metabolic adaptation. By combining proteomics, metabolomics, and LiP-MS …
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Characterization of Drosophila Scap: Analysis of Mutants and Evidence for a Retention Factor
… SREBP pathway is one of the major regulators of lipid homeostasis and it is highly conserved among metazoans. SREBP is a transcription factor whose precursor is an endoplasmic reticulum (ER) transmembrane protein. In order to be activated it must travel to the Golgi apparatus via interaction with …
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Mechanistic and Physiological Studies of the Insulin-Dependent Regulation of FOXA2
… genes involved in the maintenance of glucose and lipid homeostasis in the liver, and is constitutively inactivated in several hyperinsulinemic/obese mouse models, thereby enhancing their metabolic phenotypes. Foxa2 is activated under fasting conditions, but is inhibited by insulin signaling via …
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A pharmacokinetic and pharmacodynamic study of pioglitazone in a model of induced insulin resistance in normal horses
… controls. Parameters of clinical examination and lipid metabolism were compared prior to, and following, endotoxin administration. Pioglitazone administered orally at 1 mg/kg q 24 h resulted in plasma concentrations lower, and more variable, compared to those considered therapeutic in humans. No …
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Exploiting Chemical Libraries to Identify and Characterize Novel Bioactives with Efficacy Against Pathogenic Candida Species
… and was classified as a disruptor of cellular lipid homeostasis. Secondly, I further investigated the mechanism of action of a hit molecule from the University of Tokyo’s Core Chemical Library, NP-BTA, a compound predicted to inhibit the C. albicans glutaminyl tRNA synthetase Gln4. …
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The Role Of Crebh In Hepatic Energy Regulation Under Metabolic Stress
<p>Lipid metabolism is tightly regulated by nuclear receptors, transcription factors, and cellular enzymes in response to nutritional, hormonal, and stress signals. Hepatocyte specific, cyclic AMP responsive element-binding protein (CREBH) is a transcription factor that is preferentially expressed …
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The role of brown adipose tissue on substrate metabolism and insulin sensitivity in humans
… to explore the role of BAT in whole-body energy homeostasis, glucose and lipids kinetics, insulin sensitivity, and thermoregulation in humans. To this end, we studied men with (BAT+) or without (BAT-) detectable BAT under prolonged mild cold and thermoneutral conditions using infusion of stable …
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Analysis of the interaction between the 2C protein of parechoviruses and lipid droplets
… and also co-localised and aggregated lipid droplets. Many viruses such as hepatitis C virus (HCV) and Dengue virus recruit lipid droplets to replication complexes. We found that lipid droplets became larger in HPeV-infected cells, but do not co-localise with replication complexes. To …
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SCAP, Insig, and Cholesterol Interactions in Mammalian Cells
… and activate the numerous enzymes of cellular lipid homeostasis. When cellular sterol levels rise, the SCAP/SREBP complex binds to an ER resident protein named Insig. Upon binding to Insig, the movement of the SCAP/SREBP complex to the Golgi is inhibited, thus halting cholesterol and fatty acid …
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Hormetic dietary phytochemicals from Western Canadian plants: Identification, characterization and mechanistic insights
… in the expression of genes associated with lipid homeostasis and energy metabolism. As a whole, this work provides evidence that compounds that activate QR (and Nrf2) are widely distributed in the Canadian flora. However, of these QR activators, few are active at concentrations that are …
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