Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 218 for “"Lipid Bilayer"”.
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Investigating Cholesterol Orientation in Lipid Bilayer by Raman Spectroscopy
… ranging from different sterols to phospholipids to membrane partitioning proteins. While the overall compositions of these various elements are understood in part, how the phospholipid bilayer in cells accommodates the different processes for the copious types of proteins is not fully …
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Photoelectric Characterization of Bacteriorhodopsin Reconstituted in Lipid Bilayer Membrane
… purpose, a system was built to characterize the lipid bilayer membranes and to measure the photocurrent. The lipid bilayer membrane was characterized by its capacitance and resistance. A picoampere photocurrent was observed when Bacteriorhodopsin protein was present in the bilayer membrane and a …
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Lipid Bilayer Formation in Aqueous Solutions of Ionic Liquids
The formation of lipid bilayer membranes between droplets of ionic liquid is presented as a means of forming functional bimolecular networks for use in sensor applications. Ionic liquids are salts that have a number of useful properties, such as low melting points making them liquid at room …
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Consequences of Asymmetric Environment on the Mechanics of Lipid Bilayer
Lipid membranes are selective barriers that encapsulate cellular components and define the identity of organelles. A fundamental feature of membranes is an asymmetric distribution of lipids and proteins across them. While a basic level of asymmetry is maintained at all times, local and transient …
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Polymer Supported Lipid Bilayer Membranes for the Integration of Transmembrane Proteins
… successful formation of supported multicomponent lipid bilayer membranes (sLBMs) from natural occurring lipids as well as synthetic lipids on a set of polymer cushions consisting of alternating maleic acid copolymers. Maleic acid copolymers provide a versatile platform to adjust the …
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Eluding Antibiotic Resistance: Capitalizing On Antimicrobial Peptides Interaction With The Lipid Bilayer
<p>It is widely accepted that the emergence of drug-resistant pathogens is the result of the overuse and misuse of antibiotics. Infectious Disease Society of America, Center for Disease Control and World Health Organization continue to view, with concern, the lack of antibiotics in development, …
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Design and Testing of a Hydrogel-Based Droplet Interface Lipid Bilayer Array System
… experiments for a meso-scale hydrogel-based lipid bilayer array system. Two design concepts are investigated as methods for forming Droplet Interface Bilayer (DIB) arrays. Both concepts use a base of patterned silver with Ag/AgCl electrodes patterned onto a flat polymer substrate. In one …
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Electro-deformation of a moving boundary: a drop interface and a lipid bilayer membrane
This dissertation focuses on the deformation of a viscous drop and a vesicle immersed in a (leaky) dielectric fluid under an electric field. A number of mathematical tools, both analytical and numerical, are developed for these investigations. The dissertation is divided into three parts. First, a …
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Theoretical and computational modeling of peptide-lipid bilayer interaction studied by dynamic force spectroscopy
… that investigate different aspects of peptide-lipid membrane interactions. (1) A general theoretical approach is formulated for the quantitative description of the detachment force distribution, P(F), and the corresponding force dependent detachment rate, k(F), of a peptide from a lipid …
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Efficient coarse-grained brownian dynamics simulations for dna and lipid bilayer membrane with hydrodynamic interactions
… data and previous simulation results. (2) Lipid bilayer membranes have been extensively studied by CGMD simulations. Numerical efficiencies have been reported in the cases of aggressive coarse-graining, where several lipids are coarse-grained into a particle of size 4 ~ 6 nm so that there …
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A Study of The Effect of Membrane Targeting Antimicrobial Compounds on Ionic Transport Across Lipid Bilayer Membranes
… interactions were compared using advanced lipid membrane biophysical techniques, including in-silico structural modelling, fluorescent membrane dipole measures, differential scanning calorimetry, neutron reflectometry, dynamic light scattering and electrical impedance spectroscopy and …
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Influence of protein and lipid domains on the structure, fluidity and phase behavior of lipid bilayer membranes
The lipid bilayer forms the basic structure of the cell membrane, which is a heterogeneous matrix of proteins and lipids that provides a barrier between the interior of a cell and its outside environment. Protein and lipid domains in cell membranes can facilitate receptor localization, stabilize …
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The use of enzymes, isomerisable lipid analogues and small molecules to modulate the structure and dynamics of lipid bilayer
… the effects and interactions of isomerisable lipid analogues, small molecules, and enzyme catalysed substrates on the structure and dynamics of lipid bilayers. Modulation of Enzyme Activity Using an Azobenzene-Containing Lipid Analogue – An azobenzene-containing phosphocholine lipid analogue …
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Investigating spatial distribution and dynamics of membrane proteins in polymer-tethered lipid bilayer systems using single molecule-sensitive imaging techniques
… complex supramolecular assemblies comprised of lipids and membrane proteins. Both types of membrane constituents are organized in highly dynamic patches with profound impact on membrane functionality, illustrating the functional importance of plasma membrane fluidity. Exemplary, dynamic processes …
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Biological membrane in presence of alcohol and anti-asthma drugs: a molecular dynamics study
… of alcohol and anti-asthma drugs on phospholipid bilayer a series of atomistic molecular dynamics (MD) have been carried out. Although alcohol is widely used as a solvent in drug delivery systems, it is known that it can affect a lipid bilayer. The effect of two different alcohol molecules …
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Modeling interactions between cells and the aqueous environment
… membrane model consists of a hydrogel-supported lipid-bilayer. Hydrogels are cross-linked polymer networks that can absorb large amounts of water without dissolving or loosing their shape. A number of hydrogels are stimuli-sensitive. They can change their structures and properties in response to …
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Constitutive modeling of the finite deformation behavior of membranes possessing a triangulated networked microstructure
… by two primary microstructural features: the lipid bilayer and the underlying spectrin network. The lipid bilayer is analogous to a 2D fluid in that it resists changes to its planar area, yet poses little resistance to planar shear. A skeletal network of spectrin molecules is crosslinked to …
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A Molecular Dynamics Study on the Interaction of Tea Catechins and Theaflavins with Biological Membranes
… and theaflavins commonly found in tea with lipid bilayers, as a model for cell membranes. Previously, multiple experimental studies rationalized the anticarcinogenic, antibacterial, and other beneficial effects of these compounds in terms of physicochemical molecular interactions with cell …
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