Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Lipid–protein interactions"”.
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Lipid-protein interactions in lipid membranes
In dieser Arbeit werden Lipid-Protein-Wechselwirkungen und lipidvermittelte Protein-Protein-Wechselwirkungen mittels Monte-Carlo-Simulationen eines generischen vergröberten Modells für Lipiddoppelschichten mit hydrophoben Einschlüssen untersucht. Die Ergebnisse werden mit den Vorhersagen zweier …
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Theoretical studies of lipid-protein interactions in biological membranes
… conformational and orierjtational properties of lipids and proteins in a bilayer membrane. in the first instance, linear, hard-core tri-atomics are used to represent the two-dimensional projections of the lipid molecules. Studies on lipid only systems show that the average number of gauche …
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Studies on the Lipid-Protein Interactions of Pyruvate Oxidase
Made available in DSpace on 2014-12-13T20:10:35Z (GMT). No. of bitstreams: 1 7913605.pdf: 4194774 bytes, checksum: 833d642fed06417e585b36180ccb9408 (MD5) Previous issue date: 1978
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Lipid-protein interactions of immunoreceptor signaling subunit cytoplasmic domains
Protein-lipid interactions are emerging as key components of cellular processes such as protein and membrane trafficking and cell-cell signaling. Many proteins bind lipid reversibly, including cytoplasmic proteins involved in signal transduction, such as Ras and Src. Membrane binding is vital for …
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Role of lipid-protein interactions in modulating the membrane protein function
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Genetic and Biochemical Characterization of the Lipid-Protein Interactions of Pyruvate Oxidase
… activity (by six- to eightfold) and encode a protein having the size and antigenic determinants of pyruvate oxidase.
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The Nuclear Magnetic Resonance Study of Lipid Protein Interactions in Model Membrane Systems
… In order to determine the effect of membrane protein upon the state of lipid motion, a variety to deuterium labeled phosphatidylcholines have been synthesized and these have been reconstituted with several membrane proteins and peptides. The proteins include gramicidn A', cytochrome C oxidase …
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Elucidating the Interplay Between Lipids and Membrane Proteins Using Multiscale Computer Simulations
… structures formed by a large number of different lipid types, that also contain a variety of bound proteins, carbohydrates, and other molecules. The detailed orchestration of all these elements has been a major focus of scientific research during the last 5 decades. Computer-based methods, such as …
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Probing cellular protein complexes using single-molecule pull-down
Cellular processes result from dynamic interactions between biomolecules. The gold standard method for investigating interaction between biomolecules is the pull-down assay. We have extended the conventional pull-down assay to its ultimate limit: the analysis of single biomolecular complexes. We …
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Model Systems For Studies At The Plasma Membrane: Investigating Lipid Phase Behavior And Protein-Mediated Membrane Remodeling
… plasma membrane is a multicomponent mixture of lipids and proteins. Functional domains ("lipid rafts") that arise from nonrandom mixing of membrane components are believed to be important in governing the spatial organization of lipids and proteins. Proper compartmentalization of lipids and …
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Computational investigation of membrane-associated phenomena and viral proteins
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Membrane reconstitution studies on the irreversibility of inactivation of sarcoplasmic reticulum of rabbit skeletal muscle
… of the present study was to determine whether lipid-protein interactions, imposed by the transmembrane nature of the (Ca²⁺, Mg²⁺) - ATPase contributed towards the irreversible nature of the inactivation. This was determined by studying the possibility of reactivating calcium transport in …
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Computational study of the structure and function of membrane transport proteins
… cell membrane is regulated by membrane transport proteins which selectively and efficiently transports materials across the membrane. In the present work I focus on the family of membrane transporters the so called sugar porters in both their mammalian and bacterial forms. In the first work I …
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Omics approach towards understanding the function of bioactive lipids in osteosarcoma
… aimed at discovering the various proteomic and lipidomic biomarkers in metastatic and non-metastatic osteosarcoma as well as development of lipid mediators as potential therapeutics. We take a high-throughput approach towards identifying specific membrane proteins and lipids that are …
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Atomistic insights into the structure, dynamics, and regulation of integral membrane proteins
… offers mechanistic insights into dynamic interactions that are often inaccessible to static structural methods alone. Cell membranes and their associated proteins play essential roles in fundamental cellular processes and are implicated in numerous diseases. Understanding the dynamics and …
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Determination of fatty acid synthesis intermediates in escherichia coli and bacillus subtilis
Lipids play crucial roles in maintaining cellular structure and energy storage. Structural lipids in the form of phospholipids constitute almost 10% of the dry cell weight in bacteria with their synthesis requiring 32 moles of ATP per mole of lipid. This significant investment ensures that the flux …
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
Lipids and proteins are two major components of cells, which are crucial for structural integrity and maintenance of cellular homeostasis by integrating various extracellular and intracellular cues. Lipids are involved in the regulation of cellular functions and can interact with proteins and …
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Investigation of structural dynamics and the function of membrane proteins with computational techniques
… of MD offers insights to the highly specific interactions that dictate various biological processes. This dissertation entails the use and development of advanced simulation techniques by employing synergies between statistical mechanics, computer simulations and artificial intelligence (AI) …
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Computational investigation of membrane proteins across species and functional classes
Membrane proteins play central roles in cellular communication, metabolism, and homeostasis, yet experimental characterization of their dynamic interactions with membranes remains highly challenging. In this dissertation, I implement advanced molecular dynamics (MD) simulation workflows to …