Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"LipB"”.
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Lipoic acid assembly on 2-oxoacid dehydrogenases in E.coli
… pathway dependent on the activities of the LipB and LipA proteins and a lipoic acid scavenging pathway catalyzed by the LplA protein. LipB is responsible for octanoylation of the E2 components of 2-oxoacid dehydrogenases to provide the substrates of LipA, a SAM radical enzyme that inserts …
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Studies of Lipoic Acid Metabolism in Escherichia Coli
… In Chapter Three, the reaction mechanism of LipB was studied. It demonstrated that the E. coli LipB reaction preceded through an acyl enzyme intermediate in which octanoate was first transferred from the thiol of ACP to a specific LipB thiol. The acyl-LipB intermediate was first discovered by …
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Post-Translational Modification With Lipoic Acid in Escherichia Coli
… A second pathway was known to be dependent on lipB. I have identified lipB as the structural gene involved in the second, lplA independent pathway. I have shown that this LipB pathway utilizes lipoyl-ACP (lipoyl-acyl-carrier protein) as the lipoyl donor, establishing a link between fatty acid …
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Lipoic acid metabolism in Leishmania major
… carrier protein]: protein N-octanoyltransferase (LIPB) and lipoate protein ligase (LPLA), respectively), and it was predicted that all three proteins possess mitochondrial targeting peptides. Targeting of these proteins to the mitochondrion was verified by a green fluorescence protein (GFP) …
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Studies on lipoic acid metabolism
… in two steps. First, an octanoyltransferase (LipB) transfers an octanoyl moiety from the acyl carrier protein (ACP) of fatty acid biosynthesis to the LDs. A thioester-bound acyl-enzyme intermediate is formed in the process. Then lipoyl synthase (LipA) catalyzes replacement of single hydrogen …
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Investigations into the Metabolic Requirements for Lipoic Acid and Lipid Species During the Life Cycle of the Malarial Parasite Plasmodium Berghei
… of the lipoyl-octanoyl transferase enzyme, LipB in P. berghei parasites demonstrate a liver-stage specific need for this metabolic pathway. In order to explore the impact of the fatty acid and triglyceride content on the pathogenesis of Plasmodium parasites, this study tests two methods to …
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N-acylhomoserine lactone regulation of adhesion and biofilm differentiation in Serratia marcescens MG1
… kinase gene (rssA), a type I transporter gene (lipB), bsmA and bsmB. These four genes were found to effect the expression of type I fimbriae which is proposed to be the adhesin affecting C4-HSL regulated adhesion. While C4-HSL is not involved in adhesion to the HCE cell line, the genes bsmA and …
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Applications of powder interlayers for large gap joining
… liquid infiltrated powder interlayer bonding (LIPB) process was developed. For a material system that has a large mutual solubility between the liquid and the solid at the bonding temperature, a protective coating on the particles of the base material was applied to avoid excessive dissolution …
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Lipoic acid protein ligases in Plasmodium spp.
… carrier protein]: protein N-octanoyltransferase (LipB) catalyses the attachment of octanoyl-acyl carrier protein (octanoyl-ACP) to the PDH and lipoic acid synthase (LipA) then catalyses the insertion of two sulfurs into the octanoyl-chain to form lipoamide. In the mitochondrion, scavenged lipoic …