Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"Linkage Disequilibrium (LD)"”.
-
Network-based approach for post genome-wide association study analysis in admixed populations
… method applies centrality measures within linkage disequilibrium (LD) on the network to search for pathways and applies a scoring summary statistic on the resulting pathways to identify the most enriched pathways associated with complex diseases.
-
Fine Mapping and Evolution of a QTL Region on Cattle Chromosome 3
… was found to be associated with high milk yield in families, F1 and F2, confirming previous studies. Maternal haplotypes of offspring were then used to define linkage disequilibrium (LD) within the QTL critical region. There were 15 LD blocks found to be shared among all three sires, covering …
-
Patterns of linkage disequilibrium in the human genome
Although enormous progress has occurred in the field of human genetics, the cloning of complex trait mutations remains a challenging and unresolved process. This continuing difficulty is responsible for an ever-increasing awareness of the phenomenon of linkage disequilibrium (LD). The principle …
-
Applying ancestry tracts to human genetics: disentangling admixture history and characterizing gene conversion
… that exploits the characteristic disruption of linkage disequilibrium (LD) patterns near gene-conversion sites to classify the polarity of gene-conversions - i.e whether a converted tract is on an admixed haplotype or a reference haplotype. Finally, I present results from an empirical study into …
-
Genetic association between schizophrenia and type-2 diabetes
… and T2D, and to explore whether clozapine could affect expression of the genes associated with obesity and T2D.<br/>Methods: A total of 221 British nuclear families consisting of 148 fathers, 204 mothers and 222 affected offspring with schizophrenia were recruited for the genetic analysis. All …
-
Haplotype block and genetic association
… to estimate haplotype blocks based on pairwise linkage disequilibrium (LD). The application to simulated data shows that our new approach has higher power than several existing methods in identifying haplotype blocks. We also examine the impact of marker density and different tagging strategies …
-
GENETIC DIVERSITY AND LINKAGE DISEQUILIBRIUM IN WILD SOYBEAN, LANDRACES, ANCESTRAL, AND ELITE SOYBEAN POPULATIONS
… genome diversity and increasing the extent of linkage disequilibrium (LD). To understand the impact of these genetic bottlenecks and selection on sequence diversity and LD within soybean [Glycine max (L.) Merr.], 111 genes and three chromosomal regions located on linkage groups A2, G, and J …
-
Association Analyses of Estrogen Receptor a Gene Polymorphisms with Bone Geometric Property at The Femoral Neck in Caucasian Nuclear Families
… public health problem, especially in the elderly. The most clinical importance of osteoporosis is its association with bone fragility. Bone geometry is an important risk factor for fracture, independent to BMD, and is genetically determined. However, genetic studies on bone geometry …
-
The genomics behind beauty: disentangling the complex coat color genetic architecture of gir breed
… of population genomics, parameters such as linkage disequilibrium (LD) and effective population size (Ne) allow the characterization of population genetic structure, whereas genome-wide association studies (GWAS) enable the investigation of the genetic architecture underlying coat color. In …
-
Linkage disequilibrium and haplotype block patterns in popcorn populations
Linkage disequilibrium (LD) and haplotype blocks have been a preliminary and powerful knowledge for genomic investigates in humans, animals and plants. We aimed to describe the LD measures, D’ and r 2 , and to characterize haplotype block patterns in popcorn populations (synthetic and breeding …
-
Linking transcript, QTL and association mapping to understand the genetic control of leaf size and shape in Populus
… adaptive trait and early indicator of biomass yield. In order to investigate the genetic variance contributing to this variation in leaf size a collection of Populus nigra L. were made from across Europe and were planted at a single site in Belgium, in a fully randomized and replicated trial, with …
-
Novel Statistical Methods for Multiple-variant Genetic Association Studies with Related Individuals
… data of multiple genetic variants. Due to linkage disequilibrium (LD) and familial relatedness, the genotype data from such studies often carries complex correlations. Moreover, missing values in genotype usually lead to loss of power in genetic association tests. Also, repeated …
-
Earliness factors in Nordic spring barley (Hordeum vulgare L.) Detection of QTL for growth and development traits in a Golf x Tampar barley mapping population
… is the fourth most grown cereal crop in the world and can be successfully grown in a broad range of environments. Success of cultivation in subarctic regions such as Iceland depends largely on the ability of breeders to create high yielding cultivars that are adapted to the low temperatures, …
-
How Linkage Disequilibrium and Recombination Shape Genetic Variation Within and Between Species
… This non-random association is known as linkage-disequilibrium (LD), and it has evolutionarily important effects both within and between species. Nucleotide diversity at a given locus may be reduced by directional selection on the locus, or by selection on neighboring linked loci. …
-
Genomic changes underlying disease resistance and high protein QTL
… through examining whole genome sequence scaffolds and cloned fosmids. Compelling genomic changes in a gamma-SNAP in cqSCN-006 and CAF1 (chromosomal assembly factor 1) in cqSCN-007 are examined for their potential to be causative for SCN resistance in cqSCN-006 and cqSCN-007. Structural …
-
Associação genômica via regiões cromossômicas sob a abordagem bayesiana
… podem estar em alto desequilíbrio de ligação (Linkage Disequilibrium – LD) entre si e, com isso, influenciar conjuntamente o fenótipo. Um desses métodos é o Mapeamento de Herdabilidade Regional (Regional Heritability Mapping - RHM). Atualmente, os estudos de associação sob abordagem Bayesianas …
-
Using DNA markers to trace pedigrees and population substructure and identify associations between major histocompatibility regions and disease resistance in rainbow trout (Oncorhynchus mykiss)
… analyzed at the National Center for Cool and Coldwater Aquaculture (NCCCWA) with previously reported marker sets for a comparison of results. Each marker within the multiplex system was evaluated for duplication, null alleles, physical linkage, and probability of genotyping errors. Data from …
-
Dissecting the genetic bases of severe malaria resistance using genome-wide and post genomewide study approaches
… one of the leading public health problems worldwide. The global tally of malaria in 2018 was estimated at 228 million cases and 405, 000 deaths worldwide. African countries disproportionately carry the global burden of malaria accounting for 93% and 94% of cases and deaths, respectively. Even …
-
Disease population genetic simulation framework: towards application in modelling disease risk prediction and heritability rate
… association study (GWAS) was conducted. The field has since experienced monumental strides, as evidenced by over half a million associations submitted in the GWAS catalog today, advancements in sequencing technologies, and the development of robust methodologies for genetic data analysis. Our …
-
Identificazione di un QTL principale per resistenza a ruggine bruna sul cromosoma 7B di frumento duro
… disease of durum wheat (Triticum durum) worldwide. However, genetic and molecular mapping studies aimed at characterizing leaf rust resistance genes in durum wheat have been only recently undertaken. The Italian durum wheat cv. Creso shows a high level of resistance to P. triticina that has …
Page 1 of 2