Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Linezolid"”.
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Optimising linezolid use for drug-resistant tuberculosis: pharmacokinetics, toxicity, and resistance
… more effective, safe, and well-tolerated drugs. Linezolid is a repurposed oxazolidinone antimicrobial with bactericidal activity against M. tuberculosis. Guidelines recommend linezolid as a preferred antituberculosis agent for RR-TB, and it is widely used in national programmes. The major …
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Erhebung pharmakokinetischer Daten von Cisaprid, SC-72393, Haloperidol, Linezolid, Methotrexat und Ketoprofen nach Methodenentwicklung und Validierung durch LC-MS/MS-Detektion
… die Wirkstoffe Cisaprid, SC-72393, Haloperidol, Linezolid, Methotrexat und Ketoprofen LC-MS/MS-Methoden entwickelt oder via unabhängiger Laborvalidierung auf die lokalen Gegebenheiten transferiert und zur Bestimmung pharmakokinetischer Parameter zur Anwendung gebracht. Ziel der …
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Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series
Background: Ethambutol hydrochloride and linezolid are commonly used anti-tuberculous agents. Both agents can cause potentially blinding toxic optic neuropathy. Currently there is no low-cost, sensitive screening tool to detect early toxicity before permanent vision loss has occurred. Purpose: To …
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Improving antibiotic therapy for Mycobacterium tuberculosis
… against Mtb. In my first chapter, I developed linezolid prodrugs to deliver linezolid to the site of Mtb infection, with the aim of increasing efficacy and minimizing off-target effects. I identified two methods of incorporating linezolid into a prodrug system and then explored two prodrug …
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A retrospective study to evaluate the efficacy of trimethoprim/sulfamethoxazole (TMP/SMX) compared to daptomycin or linezolid for the treatment of infections due to methicillin-resistant <i>staphylococcus aureus</i> (MRSA)
… Main therapeutic options include Daptomycin and Linezolid, two new, expensive drugs, and trimethoprim/sulfamethoxazole(TMP/SMX), an old, inexpensive agent. Study aims were to compare the clinical efficacy and potential cost savings associated with TMP/SMX use.</p> <p>Methods: A retrospective …
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Efficacy and safety of novel and repurposed drugs for the treatment of drug-resistant tuberculosis
… and delamanid) and repurposed drugs (linezolid) are increasingly becoming available for use. However, data regarding the efficacy and safety of these drugs in drug-resistant TB patients, with or without HIV infection, from a real-life programmatic setting are lacking. This thesis aims …
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Single-Payload Bioconjugation to Native Antibodies And A General Method for the Self-Immolative Release of Amide-Containing Molecules
… successfully used to release the secondary amide linezolid, primary amide levetiracetam, and aryl amide lidocaine. Nitrophenyl, glycoside, dipeptide, and cephalosporin-based triggers were all successfully in utilised to release the FDA-approved antibiotic linezolid, showing the method to be …
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Metisiline dirençli staphylococcus aureus (MRSA) suşlarının farklı antistafilokokal ajanlara duyarlılıklarının belirlenmesi ve duyarlılıkların klinik sonuçlar üzerine etkisinin araştırılması
… MRSA enfeksiyonlarının tedavisinde daptomisin, linezolid, MRSA etkili sefalosporinler gibi farklı ve yeni antibiyotik seçeneklerinin kullanılması gündeme gelmekle birlikte, glikopeptidler hala en çok tercih edilen ajanlar olma özelliğini korumaktadır. Fakat MRSA enfeksyonlarında artan …
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Addressing challenges in the treatment of tuberculosis and tuberculosis meningitis: a pharmacometric approach
… and high-dose (10 and 35 mg/kg) rifampicin and linezolid. We estimated lumbar CSF penetration of rifampicin to be ~5%, which is in line with the results of our study in children. Linezolid CSF penetration increased with higher CSF total protein levels, peaking at 37%. Neither the duration of …
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Population pharmacokinetic and pharmacodynamic modelling to improve tuberculosis treatment
… and pretomanid and repurposed drugs, such as linezolid and clofazimine. In this thesis, we employed nonlinear mixed-effects modelling to evaluate the pharmacokinetics of first-line tuberculosis drugs isoniazid, pyrazinamide, and ethambutol in pregnancy. We assessed the pharmacokinetics and …
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The Effect of Antibiotics on Toxin Gene Expression in PVL-positive Staphylococcus aureus Strains
… Protein synthesis inhibitors clindamycin and linezolid were both caused an increase of lukSF-PV mRNA levels, but they both decreased spa mRNA levels, when cultures grown in the presence of these antibiotics for one hour. However, when cultures grown with these antibiotics for 5 hrs, …
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Cell physiology based pharmacodynamic modeling of antimicrobial drug combinations
… chloramphenicol, vancomycin, meropenem, linezolid, including dual combinations). The new cell-level approach allowed for the first time to simultaneously describe single and combined effects of the aforementioned antibiotics for different experimental protocols, in particular different …
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Epidemiología molecular de Staphylococcus spp. desde un enfoque One Health: genes emergentes e inusuales de resistencia a antibióticos y de virulencia
… isolates recovered from the IP farm showed linezolid resistance and carried the cfr gene. The genetic lineages and the antibiotic resistance and virulence genes of 56 CoPS recovered from animals with signs of infection (pigs and companion animals), were investigated. Among the isolates …
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Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
… protein expression on PG metabolite levels, linezolid was used to block protein biosynthesis. Surprisingly, linezolid dramatically reduced PG intermediate levels when used alone. When used in combination with vancomycin, linezolid only modestly reduced alternative UDP-linked PG intermediate …
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Bicyclische Triazoliumsalze als Präkatalysatoren in der asymmetrischen Benzoin- und Acyloinkondensation und asymmetrische Synthese von Oxazolidin-2-onen
… pharmacologically active molecules like Zyvox (Linezolid) or Streptazolin. In addition, application of oxazolidinones in asymmetric synthesis are well known, especially the widely used auxiliaries of Evans et al.
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A Chemical-Genetic Map of Drug Resistance in Mycobacterium Tuberculosis
… resistance against ribosome inhibitors such as linezolid and chloramphenicol. This may allow for the rational engineering of linezolid analogs to avoid the activity of OcrA. The CRISPRi chemical-genetic screen data was also used to uncover several novel mechanisms of acquired drug resistance …
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Antibacterial activity of polyunsaturated fatty acids related to chronic wound infections
… and compared them to common antibiotics Linezolid (LZD) and vancomycin(VAN). Standard antibiotic sensitivity assays were used to determine the ability of PUFAs toinhibit growth and biofilm formation. Most activity was observed against S. aureus strains.The bacteriostatic activity (minimum …
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Características clínicas de pacientes con infección por Clostridium difficile en un hospital de IV nivel Bogotá 2015-2019
… tazobactam, meropenem 15%, ertapenem 8,5%, linezolid 5,26% y 3,29% amoxicilina ácido clavulánico. El 85,8% tenían nutrición enteral, 11% mixta y 3,2% parenteral, el 94% consumían inhibidores de bomba de protones. Diabetes mellitus, insuficiencia renal, cardiaca e inmunosupresión fueron …
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Schnelles und zuverlässiges therapeutisches Drug-Monitoring mit HPLC-UV und LC/LC-MS/MS aus komplexen Matrizes
… unbekannte Arzneimittelinteraktion zwischen Linezolid und Rifampicin wurde entdeckt. <br>Mit dieser Arbeit wurden erstmalig vollautomatische Methoden zur Analyse der Einzelstoffe Fluconazol, Terbinafin und Caspofungin sowie der Stoffkombinationen Ampicillin + Sulbactam und Penicillin G + …
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Tackling Mycobacterium abscessus infection in Cystic Fibrosis
… resistance mechanisms in M. abscessus to linezolid and clofazimine. For both antibiotics, I found clonal isolates of M. abscessus spp. with varying susceptibilities and different gene expression patterns, suggesting transcriptional regulation of antibiotic resistance. Mutation- mediated …
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