Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Linear ubiquitination"”.
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Direct Regulation of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) and Feedback Regulation of Lubac Function By Caspases
… and death (via apoptosis signaling). Recently, linear ubiquitination by LUBAC (linear ubiquitin chain assembly complex) was reported to have a regulatory function in TNF-α mediated NF-κB activation. Although LUBAC is suggested to control not only NF-kB signaling but also the apoptosis pathway, …
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An investigation into the role of LUBAC and linear ubiquitin chains in antibody dependent intracellular neutralisation
… only E3 ubiquitin ligase capable of generating linear ubiquitin chains, is required for efficient neutralisation of adenovirus by TRIM21. Using a small molecule inhibitor of HOIP, I found that its E3 ligase ability is required for its function in ADIN. I also tested various domains of HOIP to …
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The Role of HOIL 1 Ubiquitin Ligase Activity in MDA5 Antiviral Signaling
… the role of HOIL1 as a critical component of the Linear Ubiquitin Assembly Complex (LUBAC), which consists of another E3 ubiquitin ligase, HOIP, and SHARPIN. The LUBAC has been shown to be a major regulator fo multiple immune-related responses by conjugating linear ubiquitin chains to multiple …