Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Linear ubiquitin"”.
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An investigation into the role of LUBAC and linear ubiquitin chains in antibody dependent intracellular neutralisation
… It requires TRIM21, an Fc receptor and E3 ubiquitin ligase that resides in the cytosol. Binding of TRIM21 to the exposed Fc portion of an antibody that is bound to an internalised virus results in ubiquitin signalling and proteasomal degradation of the virus. Viruses are large, complex …
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OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling
… a feasible strategy to overcome chemoresistance. Ubiquitination is an essential post-translational modification during which ubiquitin chains are assembled on a substrate protein, leading to various cellular processes, such as endocytosis, membrane trafficking, DNA repair, signal transduction, and …
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The Role of HOIL 1 Ubiquitin Ligase Activity in MDA5 Antiviral Signaling
… Previous work had identified that the E3 ubiquitin ligase, HOIL1, is essential for the induction of type 1 interferons in response to viral infections primarily sensed by MDA5 but is dispensable for RIG-I mediated interferon induction. However, these findings were confounded by the role of …
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LUBAC is required for the RIG-I mediated antiviral response
… we set out to understand the contribution of the linear ubiquitin chain assembly complex (LUBAC) to the sensing of RNA and RNA viruses by RIG-I. By using synthetic RNAs, 3p-hpRNA and Poly(I:C), and RNA viruses to specifically stimulate RIG-I, we confirmed the requirement of signalling proteins …
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Identifying TRAF1 Mutations as a Key Step to Develop a Targeted Therapy for Rheumatoid Arthritis
… negatively regulates NF-κB by sequestering the Linear-Ubiquitin Assembly Chain Complex (LUBAC). Recent work in the lab has identified the exact sites of interaction of human TRAF1 in both these pathways. This thesis aims to investigate and generate a mouse model to study the role of mouse TRAF1 …
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An investigation of the activation of protein kinase complexes in the MyD88 signalling network
… which indicates that the IL-1-stimulated, LUBAC (linear ubiquitin chain assembly complex)-catalysed formation of Met1-linked/linear ubiquitin (Met1-Ub) chains and their interaction with the NEMO (NF-kB essential modulator) component of the canonical IKK complex permits the TAK1-catalysed priming …
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Investigating the function of TRAF1 in NF-κB activation
… negatively regulates NF-κB by sequestering the linear ubiquitin assembly complex (LUBAC). Because of the complex role of TRAF1 in NF-κB activation, it is important to isolate and study the role of TRAF1 in each of these pathways. To better understand TRAF1 and its role in NF-κB activation, our …
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Direct Regulation of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) and Feedback Regulation of Lubac Function By Caspases
… and death (via apoptosis signaling). Recently, linear ubiquitination by LUBAC (linear ubiquitin chain assembly complex) was reported to have a regulatory function in TNF-α mediated NF-κB activation. Although LUBAC is suggested to control not only NF-kB signaling but also the apoptosis pathway, …
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Age related memory loss and the role of the ubiquitin proteasome system
… as the accumulation of damaged proteins. The ubiquitin-proteasome system (UPS), responsible for breaking down damaged proteins, exhibits dysfunction in neurodegenerative disorders like Alzheimer's disease or dementia. While we acknowledge that proteasome function declines with age, its …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… manner. This strain is coated by ubiquitin and by the individual subunits (HOIP, HOIL-1, and Sharpin) of the linear-ubiquitin assembly complex (LUBAC). Autophagy cargo receptors, such as NDP52, p62, and Optineurin, are also recruited to the type II, intracellular parasites. …
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Investigation into ubiquitin signalling in response to cisplatin
… for new chemotherapeutic drugs. It is known that ubiquitination is important for the regulation of the ICL response and it is thus probable that some ubiquitin-related proteins have previously unidentified roles in this process.<br/>This thesis describes the use of a robust high throughput siRNA …
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Identification and characterization of phosphoinositide-binding Legionella effector proteins
… of chapter 3, RavD was reported to be a deubiquitinase (DUB) that cleaves linear ubiquitin present on the LCV. Establishing the link between RavD’s DUB activity and function in preventing phagosomal maturation of the LCV will certainly provide valuable insight into how this pathogen can …