Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Linear energy transfer (LET)"”.
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Micronuclei induction in AG01522 cells is independent of temperature and linear energy transfer
… of temperature as an experimental parameter and linear energy transfer (LET) dependence on the bystander effect. Using the micronucleus assay and primary human AG01522 fibroblast cells co-cultured as both the target and bystander cells, the incidence of micronuclei in both X-ray irradiated and …
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Evaluation of Radiobiological Effects in Intensity Modulated Proton Therapy : New Strategies for Inverse Treatment Planning
… calculations of the dose averaged linear energy transfer (LET) as a measure of the local radiation quality, and on a simple phenomenological approach for the RBE as a function of dose, LET and tissue type. It was found that the biological effect depended strongly on the type of …
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Radiobiology of normal rat lung in Boron Neutron Capture Therapy
… and provides a mixed field of high and low Linear Energy Transfer (LET) radiation with differing biological effectiveness. This project investigated the radiobiology of normal rat lung in BNCT and measured the relative biological effectiveness factors for the lung. Rat thorax irradiations …
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Radiation Damage in CMOS Image Sensors for Space Applications
… used for Earth observation. Damage from high energy protons in the space environment decreases the Charge Transfer Efficiency (CTE) and increases the dark current of such devices. Experimental work on proton damaged devices is presented, showing the effects on CTE and dark current. The results …
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Evaluation of 64Cu-ATSM in cell culture for potential use as a radiotherapy agent
… tumors display resistance to traditional low linear energy transfer (LET) external beam radiotherapy (EBRT), instigating interest in finding alternative and more effective means to treat these tumors. 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu-ATSM) has shown clinical usefulness in …
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Experimental approaches for the production of thorium-229
… in the body, where it decays by releasing high-energy (5-8 MeV) α-particles with high linear energy transfer (LET) over a short (50-100 µm) range and relatively low toxicity to the rest of the body. Actinium-225 is an ideal radioisotope for TAT due to its short half-life (t1/2=9.92 days) and 3 …
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“Acid-spike” effect in spurs/tracks of the low/high linear energy transfer radiolysis of water : potential implications for radiobiology and nuclear industry
… formed within spurs or tracks of the low or high linear energy transfer (LET) radiolysis of pure, deaerated water at early times. The in situ radiolytic formation of H3O+ renders the spur and track regions temporarily more acid than the surrounding medium. Although experimental evidence for an …
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Shedding Light on the Biological Effects of Ionising Radiation on DNA Using Advanced Optical Microscopy
… damages. CDD complexity increases with rising linear energy transfer (LET) of radiation, while repairability decreases. This makes high-LET IR more biologically effective than low-LET. Understanding DNA repair mechanisms and associated signalling with radiation quality, may be useful in …
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Dosimetry calibration for low-energy protons produced in the ECU accelerator laboratory
… their ability to deposit the majority of their energy within a well-defined and localized volume inside the body, thereby maximizing tumor dose while minimizing irradiation of surrounding healthy tissues. Despite these advantages, continued experimental and methodological studies are required to …
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Modeling Proton Relative Biological Effectiveness Using Monte Carlo Simulations of Microdosimetry
… of the Bragg peak, a narrow region of rapid energy loss. Proton therapy is also known to offer an enhanced relative biological effectiveness (RBE) compared to photons. In the current clinical standard, RBE is fixed at 1.1 at all points along the proton beam, meaning protons are assumed to …
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Modification and Implementation of The Rpc Heterogeneous Thorax Phantom For Verification of Proton Therapy Treatment Procedures
… was measured using a CT scanner. The relative linear stopping power (RLSP) of these materials was measured. The linear energy transfer (LET) of Gafchromic EBT2 film was analyzed utilizing parallel and perpendicular orientations in a water tank and compared to ion chamber readings. Both parallel …
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High-Throughput Mapping of The Biological Effects of Particle Therapy
… particle radiation has been shown to have linear energy transfer (LET) specific relative biological effectiveness (RBE) when compared to photons. It is essential to employ accurate biophysical models for particle beams in order to maximize the therapeutic potential of particle therapy …
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The application of experimental microdosimetry to mixed-field neutron-gamma dosimetry
Absorbed dose distributions in lineal energy for neutrons and gamma rays were measured by using both a tissue-equivalent walled counter (TEPC) and a graphite-walled low pressure proportional counter (GPC) in the Am-Be neutron source facility at University of Ontario Institute of Technology. A …
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Comparison of the Effects of Cobalt-60 [gamma]-Rays and Tritium [beta][superscript -]Particles on Water Radiolysis and Aqueous Solutions and Radiolysis of the Ceric-Cerous Sulfate Dosimeter at Elevated Temperature
… examine the importance of the effects of higher “linear energy transfer” (LET) by comparing [[superscript 3]H [beta][superscript -] radiations (mean initial energy of ~5.7 keV) with [superscript 60]Co [gamma]-rays (~1 MeV electrons). Our simulations showed that, for [superscript 3]H …
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3D Scintillator Detector Quenching Characterization For Scanning Proton Beams
… ionization density, which is quantified as the linear energy transfer (LET), varies as a function of depth. Therefore, quenching introduces a non-linear response to the absorbed dose of proton beams. To fully utilize volumetric scintillator detectors for dose verification, ionization quenching …
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Monte Carlo simulation of the radiolysis of water by fast neutrons at elevated temperatures up to 350°C
… °C. In this work, we chose 2-MeV neutron as our energy of interest since it is known as representative of a fast neutron flux in a nuclear reactor. For light water, for that chosen energy, the most significant contribution to the radiolysis comes from the first four neutron collisions that …
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Ion dosimetry for radiobiology experiments employing laser-accelerated beams
… energies, which is thought to be linked to their linear energy transfer (LET) value. <br/><br/>The main aims of the first experimental chapter in this thesis are to investigate the relationships between particle LET and RCF optical density response to dose delivered by particles accelerated with …
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Radiation biophysical modeling of the FLASH effect: from mechanistic understanding towards clinical endpoint prediction
… qualities, namely, particle types, energies, and linear energy transfer (LET). In particular, it has been demonstrated using electron LINACs, showed for UHDR irradiation a significant sparing of animals from cognitive deficits in learning and memory. The FLASH effect has been seen using proton …
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Evaluation of Polymer Gel Dosimeters For Measurements of Dose and Let In Proton Beams
… as tools for measuring the dose deposited by and LET of a proton beam. A total of three BANG® dosimeter formulations were evaluated: BANG®-3-Pro-2 BANGkits™ for dose measurement and two BANG®-3 variants, the LET-Baseline and LET-Meter dosimeters, for LET measurement. All dosimeters were read out …