Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Lineage plasticity"”.
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DYNAMIC BEHAVIOR AND LINEAGE PLASTICITY OF THE PULMONARY VENOUS ENDOTHELIUM
Repair of the pulmonary vascular bed and the origin of new vasculature remains underexplored despite the critical necessity to meet oxygen demands after injury. Given their critical role in angiogenesis in other settings, we investigated the role of venous endothelial cells in endothelial …
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Oligodendrocytes of the adult median eminence
… revealed nutritional regulation of the ME OL lineage. Diet induced obesity, for example, blunts OL generation and turnover and increases ME myelin amounts, whereas caloric restriction reduces ME OPC differentiation and myelination. Intriguingly, blocking new OL generation in the adult brain …
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The oligodendrocyte lineage of the median eminence in the adaptation to diet-induced obesity
… the ME resides a population of oligodendrocyte lineage cells which display a uniquely high degree of plasticity; Typically, populations of oligodendrocytes are long-lived, supporting their role in myelinating neuronal axons and providing trophic support to neurons. Meanwhile, oligodendrocyte …
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PHF6 modulates the chromatin landscape in B-cell leukemia
Developmental and lineage plasticity have been observed in numerous malignancies, and have been correlated with tumor progression and drug resistance. However, little is known about the molecular mechanisms that enable such plasticity to occur. Here, we describe the function of the Plant …
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SOX2 is Associated with Changes in DNA Damage Repair and Cell Cycle Gene Expression and Regulates E2F1
… Previously, SOX2 was found to promote lineage plasticity and resistance to AR-targeted therapies in prostate cancer. Further, the SOX2 protein is either present or absent in a prostate cancer tumor, making it an ideal biomarker. Our studies show that metastasis samples from prostate …
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Defining oncogenic determinants in prostate cancer initiation and progression
… alteration KMT2C associated with this phenotype. Lineage plasticity is recognized as a common mechanism for treatment resistance in cancer. The shift from an androgen receptor (AR)-positive lineage to an AR-negative lineage has increased over the past decade due to the use of 2nd generation AR …
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Genetic analysis of Kmt2d loss in tumorigenesis using genetically engineered mouse models
… enhancer landscape in determining cellular lineage in embryonic development, it is unknown whether enhancer dysregulation caused by <em>KMT2D</em> loss leads lineage switch of tumor cells, which has been associated with tumor progression and therapeutic resistance in human cancers. To …
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Defining metabolic zonation as a determinant of hepatocyte plasticity
… hepatocytes possess this propensity or whether lineage plasticity is zonated within the lobule. This study aimed to investigate whether the position of hepatocytes along the axis of the lobule is a determinant of hepatocyte plasticity. This was achieved through two independent approaches, the …
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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… of the JAK/STAT pathway, all culminating in lineage plasticity and resistance. This unique shift of AR into an oncogene (previously unreported for the tumor suppressor class) and increase in JAK/STAT signaling switches the tumor cells from luminal ER-positive breast cancer to an intermediate …