Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Lineage Tree"”.
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Somatic phylogenies: a window into human biology in health and disease
… rise to what i.e. the structure of the somatic lineage tree. For this purpose, it is fortuitous that most cell divisions result in the acquisition of somatic mutations that are passed on to all of its future progeny. Therefore theoretically, if all somatic mutations in each cell of an organism …
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Speciation dynamics of an agent-based evolution model in phenotype space
… advantage regardless of its phenotype location. Lineages of organisms evolve by limiting the maximum possible offspring distance from their parent(s) (mutability, which is the only heritable trait) along each coordinate in phenotype space. As mutability is varied, a non-equilibrium phase …
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Resolving developmental dynamics using single-cell sequencing data
… developing mouse forebrain. Most importantly, a lineage tree inference allows for an unprecedented description of the switch from neurogenesis to gliogenesis identifying primed cell states and branching points. I continue with an application of the forebrain atlas comparing brain development and …
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Understanding the Dynamics of Embryonic Stem Cell Differentiation
… the ability to give rise to all cell lineages in the adult body. In addition to being a unique and interesting cell type, pluripotent ES cells have demonstrated their potential for continued advancements in biomedical science. Currently, there is an improved understanding in the …