Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Lignan"”.
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
… The literature indicates the ability of flaxseed lignans to improve cholesterol blood profiles. However, the mechanism by which the metabolites of the non-bioavailable plant lignan, secoisolariciresinol diglucoside, modulate blood cholesterol levels is not yet known. This study examines a possible …
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Multicomponent Cyclization Reactions: A General Approach To Dibenzocyclooctadiene Lignan Natural Product
… applicable route to dibenzocyclooctadiene(DBCOD) lignans, an important class of natural products with wide-ranging biologicalactivities, we applied Pd-catalyzed bis-metallative cyclizations mediated by a [B-Sn] reagent,1-trimethylstannyl-2,5-dimethyl-2,5-diazaborolidine, to access the core DBCOD …
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Protective role of lignan-converting bacteria on chemically-induced breast cancer in gnotobiotic rats
Enterolignans (enterodiol and enterolactone) exhibit structural similarity to estradiol and have therefore been hypothesized to modulate hormone related cancers such as breast cancer. The bioactivation of the plant lignan secoisolariciresinol diglucoside (SDG) requires the transformation by …
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EFFECT OF COMBINATION OF THE MAMMALIAN LIGNAN, ENTEROLACTONE, WITH TYROSINE KINASE INHIBITORS ON MARKERS OF HEPATIC FIBROSIS
… of the combination of the bioactive mammalian lignan, enterolactone (ENL), and selected tyrosine kinase inhibitors (TKIs) and to explore whether these effects involve peroxisome proliferator-activated receptor gamma (PPARγ), oxidative stress, and/or endoplasmic reticulum (ER) stress, known …
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THE EFFECT OF FLAXSEED AND ITS LIGNAN COMPONENT ON ESTROGEN SIGNALING AND METABOLISM IN NORMAL AND CANCEROUS HEN OVARIES
… cancer (OvCa) is the most fatal gynecological malignancy, with over 21,290 new cases diagnosed in 2015. The 5 year survival rate for patients diagnosed at Stage IV is 17% in the United States. It has been reported that estrogen (E2) can promote metastasis of ovarian tumor cells through its …
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Synthesis of labelled precursors of podophyllotoxin
Podophyllotoxin is an aryltetralin lignan and anticancer agent produced by the <i>Podophyllum</i> and some other species and is extracted from Podophyllin in up to 30 percent yield. Little definitive information is available on the biosynthetic pathways to podophyllotoxin. Administering various …
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Study of podophyllotoxin biosynthesis in Podophyllum species
Lignans are a structurally diverse group of phenylpropanoid metabolites widely distributed throughout the plant kingdom. Their biogenetic pathway has generally been viewed to occur via coupling of two monomeric moieties, with subsequent modifications as required to afford the various Iignan …
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The Comparison of Rat and Human Intestinal and Hepatic Glucuronidation of Enterolactone Derived from Flaxseed Lignans
The mammalian lignan, enterolactone (EL), is a gut microbe metabolite of plant lignan secoisolariciresinol diglucoside (SDG), which is most abundant in flaxseed. Numerous epidemiological, experimental and clinical studies suggest the protective effects of EL against various chronic diseases such as …
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The study of the asymmetric synthesis of lignans
… thesis focuses on the asymmetric synthesis of lignans by approaches such as Diels-Alder reactions, asymmetric alkylation reactions, and intramolecular oxidative coupling reactions. In addition to developing asymmetric synthetic methodologies for chiral lignans, an investigation of chirality in …
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Evaluation of a modified food frequency questionnaire to measure lignans in Australian men and women
… against chronic diseases. Isoflavonoids and lignans are two main classes of phytoestrogen that have been investigated for their estrogenic efficacy and occurrence in the human diet. Isoflavonoids are found in soy and related products, whereas lignans are found in a wider range of plant-based …
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Elucidating binding modes of zuonin A enantiomers to JNK1 via in silico methods
… and cancer conditions. Enantiomers of the lignan zuonin A, (-)-zuonin A and (+)-zuonin A, have been shown to bind to JNK isoforms with similar affinity and disrupt protein-protein interactions at JNK's D-recruitment site, making them a good candidate for specific non-ATP competitive …
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Isolation and Structure Elucidation of Cytotoxic Natural Products from Suriname and Madagascar
… one compound. It was identified as the known lignan deoxypodophyllotoxin and was responsible for the bioactivity. It was identified by a comparison of its spectral data to those found in the literature and those of an authentic sample.
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Synthesis of Lignans Utilising the Acyl-Claisen Rearrangement: Total Syntheses of (+)-Ovafolinin A, B, (–)-Bicubebin A, B and (+)-Bicubebin C
Lignans are a diverse class of natural plant products which continue to provide new chemical structures as potential biologically active compounds. The recent syntheses of lignans has allowed for the development of new synthetic methods, confirmed or corrected proposed structures for these natural …
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Synthesis of analogues of nordihydroguaiaretic acid and their oxidative metabolism
… for the cytotoxicity of the naturally occurring lignan nordihydroguaiaretic acid, the synthesis of four structural analogues of NDGA is proposed for the purpose of studying their oxidative metabolism. One analogue in particular (1), a mono-catechol analogue, is successfully synthesized employing …
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Removal of Cyanogenic Glycosides in Whole Flaxseed via Lactobacillaceae Fermentation
… because it enriches with omega-3, dietary fiber, lignan and protein. Whole flaxseed can be added to bakery products including breads, buns, and cookies to increase the health benefits of these foods. However, flaxseed contains cyanogenic glycosides (CGs), including linamarin, linustatin, …
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Studies on the biosynthesis of podophyllotoxin:synthesis of labelled yatein and matairesinol, two potential precursors of podophyllotoxin
Podophyllotoxin, a naturally occurring lignan isolated from several species of Podophyllum, is used as a precursor to the clinical chemotherapeutic agents teniposide and etoposide. The biosynthesis of podophyllotoxin is not fully understood, but its optical activity, like that of most lignans, is …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
Prostate cancer (PC) is the most commonly found malignancy among men globally. Many genetic and epigenetic factors involving multiple cellular signaling networks are implicated in the initiation, progression, and metastasis of this disease. Therapeutic drug resistance and hormone-sensitive and/or …
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Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… several known bioactives including fibers, lignans, alpha-linolenic acid, and linoorbitides (LOBs) are believed to impart those pharmacological activities. Previous studies have focused on the ability of flaxseed bioactives to provide their pharmacological action in the systemic circulation. …
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Dietary intervention with whole flaxseed or vitamin D has beneficial effects on leiomyomas in the oviduct of the laying hen
… and vitamin D3. Flaxseed consists of two parts: lignan and oil. The lignan portion of flaxseed contains phytoestrogens which may inhibit fibroid growth through the antagonism of estrogen. Flaxseed oil is rich in α-linolenic acid, which has known anti-inflammatory properties. Vitamin D3 is a …
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Antioxidant properties of flaxseed lignans using in vitro model systems
… the antioxidant properties of flaxseed lignans secoisolariciresinol (SECO 2) and secoisolariciresinol diglycoside (SDG 1) and their major oxidative compounds using 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH 47) in an in vitro model of lipid peroxidation. This investigation was …
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