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Showing 1 to 20 of 143 for “"Light chain"”.

  1. Neurofilament light chain

    Kleist, EmilyChristian-Albrechts-Universität zu Kiel

    … untersuchte den Biomarker Neurofilament light chain (NfL) bei Patient*innen mit Status epilepticus. Zu den zentralen Fragestellungen gehörte der Vergleich mit neurologisch gesunden Kontrollen, die Unterscheidung zwischen verschiedenen Statusformen sowie die prognostische Aussagekraft des …

    cau-kiel Repository record

  2. Proteolytic studies on myosin light chain kinase

    Opleta, Karen1985

    manitoba Repository record

  3. Structural determinants of cardiac light chain amyloidosis

    Piehl, Dennis W.University of Illinois at Urbana-Champaign2018

    Light chain amyloidosis (AL) is an acute systemic amyloid disease in which the overexpression and misfolding of immunoglobulin light chains leads to the formation of insoluble fibrils at critical organs in the body. The typical prognosis for AL patients is extremely severe—usually less than three …

    uiuc Repository record

  4. Ontogeny Of Murine Immunoglobulin Light Chain Isoelectric Diversity.

    Lejeune, Joseph Mark

    uab Repository record

  5. The Modulation Of Human Platelet Myosin Light Chain Phosphorylation By Calpain I.

    Brumley, Lynn Marie

    uab Repository record

  6. Orientation of the Cardiac Myosin Regulatory Light Chain Determined by Polarized Fluorescence

    Kampourakis, ThomasKing's College London2012

    The regulatory light chain (RLC) of myosin is a component of the lever arm of the<br/>myosin motor in muscle thick filaments. Phosphorylation of RLC by myosin light<br/>chain kinase (MLCK) modulates the force and speed of muscle contraction, but the mechanisms of RLC‐mediated regulation in striated …

    kings Repository record

  7. Characterization of Smooth Muscle Myosin Light Chain Kinase Using Crystallization and Transient Kinetics

    Phan, JasonUniversity of Nevada, Reno2015

    … 75 amino acid segment of smooth muscle myosin light chain kinase (MLCK N1-75). As of now, the exact mechanism by which MLCK interacts with actomyosin complexes in smooth muscle is not well-understood because there is no highresolution 3-dimensional structure of MLCK available. In this project, …

    unr Repository record

  8. A Novel Collapsing Response Mediator Protein 2 Binding Domain for Kinesin Light Chain 3

    Faghfor Maghrebi, Mohammad AminGraduate Studies2016

    … kinesin proteins. KLC3 is the only known kinesin light chain expressed in elongating spermatids that develop the flagellum. In this study, we investigated the expression of CRMP2 in mouse testis and we studied if CRMP2 and KLC3 interact. We observed CRMP2 mRNA expression in testis, along with …

    calgary Repository record

  9. Evaluation of Neurofilament Light Chain as a Biomarker in Dogs with Structural and Idiopathic Epilepsy

    Fowler, Kayla MarieVirginia Tech2023

    … study is to assess the use of neurofilament light chain (NfL) as a biomarker for diagnostic and therapeutic monitoring in dogs with idiopathic and structural epilepsy. A total of 50 dogs (36 idiopathic epilepsy and 14 structural epilepsy) were enrolled to contribute a total of 58 samples (52 …

    vt Repository record

  10. Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction

    Zahs, Anita1970

    … alone. Long (210 kDa) smooth muscle myosin light chain kinase (MLCK), an enzyme important for epithelial tight junction maintenance, has been implicated in barrier alterations after burn injury or ethanol exposure alone. With this knowledge, <underline>we hypothesize that the combination of …

    loyola-thes Repository record

  11. Regulation of Accessibility of the Variable Gene Segments of the Mouse Immunoglobulin Kappa Light Chain Gene Locus

    Brekke, Katherine Meyers2010

    … of the expression of antibody heavy and light chain molecules is required to fully explain the adaptive immune response. This involves understanding the mechanisms underlying the selection of individual Vκ genes for V-J joining. It has been assumed that this selection involves alterations …

    utswmed Repository record

  12. The influence of myosin regulatory light chain phosphorylation on the contractile performance of fatigued mammalian skeletal muscle

    Gittings, William J.Brock University2009

    ABSTRACT The myosm regulatory light chain (RLC) of type II fibres is phosphorylated by Ca2+ -calmodulin dependent myosin light chain kinase (skMLCK) during muscular activation. The purpose of this study was to explore the effect of skMLCK gene ablation on the fatigability of mouse skeletal muscles …

    brock Repository record

  13. Interactions of Smooth Muscle Myosin Filaments with Actin and Myosin Light Chain Kinase: Insights into the Mechanics of Smooth Muscle Contraction

    Haldeman, Brian D.2015

    … by phosphorylation of the myosin regulatory light chain (RLC). Upon phosphorylation of Serine 19 of the RLC of SMM by myosin light chain kinase (MLCK), SMM filaments and actin (thin) filaments slide over one another and the cell contracts. The effect of the filamentous conformation of SMM on …

    unr Repository record

  14. Insights into structure, dynamics of thioredoxin reassembly and dynein light chain 8 and ionization states of thiamin cofactor by MAS NMR spectroscopy

    Paramasivam, SivakumarUniversity of Delaware2011

    … E. coli thioredoxin reassembly and dynein light chain 8 (DLC8) in the solid state are carried out yielding atomic-level details, as discussed in Chapters 2, 3, and 4. Second, ionization and tautomeric states of thiamin diphosphate cofactor (ThDP) in large protein, ThDP-dependent family of …

    udel Repository record

  15. MATHEMATICAL MODELLING OF CALCIUM DEPENDENT ACTIVE CONTRACTION IN A GASTROINTESTINAL SMOOTH MUSCLE CELL

    VIVEKA GAJENDIRAN2011

    … by calcium dependent activation of Myosin Light Chain Kinase (MLCK) which is the primary mechanism has been described in terms of two interacting modules - the first module describing the activation of MLCK, and the second describing cross-bridge formation between actin and myosin. Second, …

    nus Repository record

  16. Golgi Specificity and Development of Autoreactive B Cells

    Nawazi, Fazlullah Salar Khan2016

    <p>B cell receptors with certain heavy/light chain pairs predominate in the periphery of anti-DNA heavy chain transgenic mice while certain other B cell receptors are absent. We wanted to know why. To answer this, we re-constructed B cell receptors represented in the anti-DNA transgenic mice by …

    tenn-hsc Repository record

  17. The Arrangement of the Disulfide Bonds in a γG Immunoglobulin Molecule

    Gall, William Einar

    … by sedimentation equilibrium. The component light (molecular weight 22,500) and heavy (molecular weight 51,600) chains were isolated in high yield by gel filtration after reduction and alkylation under mild conditions. Amino terminal analyses and the amino acid compositions of the native …

    rockefeller Repository record

  18. Conformational Studies of Myosin and Actin with Calibrated Resonance Energy Transfer

    Xu, JinUniversity of North Texas2000

    … nucleotide site, subfragment-2, and regulatory light chain to examine nucleotide analog-induced structural transitions. The distances between the three positions were measured in the presence of different nucleotide analogs. No distance change was considered to be statistically significant. The …

    unt Repository record

  19. MODULATION OF THE B-CELL REPERTOIRE IN RHEUMATOID ARTHRITIS BY TRANSIENT B-CELL DEPLETION

    Rouzière, Anne-SophieUniversität Würzburg

    … in the distribution of immunoglobulin heavy and light chain genes can be observed. B-cell depletive therapies have beneficial effects in patients suffering from rheumatoid arthritis (RA), highlighting also the central role of B-cells in the pathogenesis of this disease. Nevertheless, the …

    wurz-thes Repository record

  20. Effect of disruption of 3D8 complementarity-determining regions on properties of 3D8 antibody

    이, 지연2012

    … on the function of an antibody, 3D8 scFv (single chain variable fragment; variable region of heavy chain connected to variable region of light chain by (G4S1)3 linker) which has DNA-binding/-hydrolyzing, heparin-binding and cell-penetrating activities. We generated single CDR-disrupted antibodies …

    ajou Repository record

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