Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Ligand-gated chloride channel"”.
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Charakterisierung der proteolytischen Spaltung des Glycin-Rezeptors im Endozytoseweg von Xenopus-Oozyten
The Glycin-Receptor (GlyR) is a ligand-gated chloride channel which mediates postsynaptic inhibition in spinal cord, retina and other regions of mammalian central nervous system. It is activated by the addition of glycine. Presently, four ligand-binding Alpha subunits (Alpha1- Alpha4) and a single …
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Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
… parasitic nematode γ-aminobutyric acid (GABA) gated chloride channel that may prove to be a novel drug target. The objective of this thesis was to characterize intramolecular interactions of Hco-UNC-49B. Two sets of oppositely charged residues were chosen based on their proximity to each other …
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Molecular characterization of GABA receptor subunits from the parasitic nematode Haemonchus contortus
… by several nematocides which target ion channels. We have identified two H. contortus ion channel genes, Hcounc- 49B and C that encode two GABA-gated chloride channel subunits. Electrophysiological analysis shows that the Hco-UNC-49B subunit forms a functional homomeric channel in Xenopus …
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Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.
… of them. Therefore, novel drug targets such as ligand-gated chloride channels (LGCCs) need to be characterized. The objective of this thesis was to further characterize the agonist binding pocket in Hco-UNC-49BC, the LGCC gated by γ- aminobutyric acid (GABA) within H. contortus. To meet this …