Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Ligand gated Ion channels"”.
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Computational modeling and simulation of ligand-gated ion channels
The pentameric ligand-gated ion channel (pLGIC) superfamily, from bacteria to the brain, convert chemical signals into electric signals. These proteins are composed of two distinct domains; the extracellular domain (ECD), where the chemical compounds (ligands) bind, and the transmembrane domain …
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Evolutionary Analysis of Acetylcholine Receptors Type of Ligand-Gated Ion Channels
"In this thesis I have reconstructed the evolutionary history in animals where I focused on analyzing the complete genomes of seven widely different animals. My strategy of using complete genomes is based on ""absence of evidence is evidence of absence"". Of course there are gaps in the genetic …
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Molecular determinants of conductance and charge-selectivity in pentameric ligand-gated ion channels
Pentameric ligand-gated ion channels (pLGICs) are a superfamily of neurotransmitter-gated ion channels, that includes (in vertebrates) the nicotinic Acetylcholine Receptor (AChR), Serotonin Receptor type 3 (5-HT3R), γ-Aminobutyric acid Receptor type A (GABAAR), and the Glycine Receptor (GlyR). All …
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The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels
The pentameric ligand gated ion channel super family plays a central role in fast synaptic communication between neurons and at the neuromuscular junction. Extensive studies on the prototypic pLGIC, the Torpedo nicotinic acetylcholine receptor (nAChR) have revealed an exquisite lipid sensitivity, …
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Development and application of quantitative ligand-binding studies to elucidate mechanistic aspects of pentameric ligand-gated ion channels
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Characterization of the ACC-1 Family of cys-loop ligand gated ion channels from the parasitic nematode Haemonchus contortus.
Nematode cys-loop ligand-gated ion channels (LGICs) have been extensively studied for decades because of their role in current anthelmintic action and potential as targets for future drugs. Many families of cys loop receptors have not yet been pharmacologically characterized in parasitic nematodes, …
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Analysis of ion channel stochastic signals for biosensing
… muscle or nerve cells, produce quick depolarizations in response to electrical, mechanical or chemical stimuli: this means that they can change their internal potential through a quick exchange of ions between cytoplasm and the external environment. This can be done thanks to the presence of ion …
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Swarna Ramaswamy_Thesis
<p>STRUCTURAL INVESTIGATIONS OF LIGAND GATED ION CHANNELS</p> <p>Swarna Ramaswamy, B.S</p> <p>Advisor: Vasanthi Jayaraman, Ph.D.</p> <p>Ion channels form an integral part of membrane proteins. In the nervous system including the central and the peripheral nervous system, ligand gated ion channels …
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Identification and characterization novel of cystine-loop ligand- gated chloride channels from Dirofilaria immitis: pharmacological analysis and novel compound screening
… is developing at an alarming rate. Cystine-loop ligand-gated ion channels are important receptors in nematode neurobiology, and as such are promising drug targets. The UNC-49 (GABA-gated chloride channel) and ACC (acetylcholine-gated chloride channel) family of receptors have been characterized …
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Agonist-Induced Conformational Changes In The Nmda Receptor
<p>NMDA receptors are ligand-gated ion channels that mediate a number of physiological and pathological phenomena within the mammalian central nervous system. Under the typical course of activation, these receptors bind to glycine and glutamate molecules and undergo a series of conformational …
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The identification of novel cys-loop receptor genes in Dirofilaria immitis
… anthelmintic resistance is emerging. Cys-loop ligand-gated ion channels are an untapped source for drug targets essential for nematode neurotransmission. This thesis presents the isolation and preliminary pharmacological characterization of three inhibitory D. immitis ion channels: GLC-2, …
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Isolation and partial characterization of three acetylcholine-gated chloride channels in Haemonchus contortus
… nature. The ability to manage infection has been confounded by the rapid development of antiparasitc drug resistance in H. contortus populations. The Cys-loop superfamily of ligand gated ion channels are well recognized as critical drug targets for many invertebrate specific …
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The heteromeric 5-HT3A/B receptor:the effect of 5-HT3B subunits on receptor structure and ligand recognition
… receptors are members of the cys-loop family of ligand-gated ion channels. Two functional subtypes are known, the homomeric 5HT3A and the heteromeric 5HT3A/B receptors, which exhibit distinct biophysical characteristics but are difficult to differentiate pharmacologically. Atomic force microscopy …
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Regulation of Expression and Function of Neuronal Nicotinic Receptors by Accessory Subunits
… perturbs the biogenesis and trafficking of these channels. The α4β2 and α3β4 subtypes are the most abundantly expressed nAChRs in the central and peripheral nervous system, respectively, and are key mediators of nicotine dependence and withdrawal. These nAChRs are heteropentameric ligand-gated ion …
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Structure and Function of the Alpha3Beta4 Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that are essential for the proper function of the central and peripheral nervous systems. The α3β4 subtype is highly expressed in the autonomic ganglia, where it contributes to signal transduction from the central nervous …
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Isolation and partial characterization of three members of the GGR-1 family in the parasitic nematode Haemonchus contortus
… estimated to cost the agricultural industry billions of dollars each year in management. Reliance and overuse of drugs has resulted in resistance, and there is an urgent need for novel anti-parasitic drugs. Cys-loop ligand gated ion channels have been recognized as important invertebrate specific …
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A Structural and Computational Study of GABAA Receptor Diversity
GABAA receptors (GABAARs) are pentameric ligand-gated ion channels that modulate the activity of neural circuits in response to binding of the neurotransmitter $\gamma$-aminobutyric acid (GABA) or small molecule therapeutics, such as benzodiazepines or general anaesthetics. GABAARs assemble from a …
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Cells that Kill: The Chemosensory Cell Types of Aedes aegypti Mosquitoes
… cues is the fundamental start of any brain function, computation, or behavior. For my doctoral work, I studied chemosensation in the Aedes aegypti mosquito, which can detect cues including human odor, carbon dioxide, and insect repellents. Mosquitoes are human's deadliest predator, causing …
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The emerging role of the a4(+)a4(-) interface as a determinant of functional signatures of a4ß2 nicotinic acetylcholine receptors
… sensitivity. Being heteromeric pentameric ligand-gated ion channels (pLGIC), a4p2 receptors are activated by binding of agonist to sites located at the a4( + )/P2( -) interfaces. These interfaces are present in both stoichiometries they are unlikely to contain structural differences …
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