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Showing 1 to 3 of 3 for “"Ligand diffusion"”.
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Ligand Diffusion Pathways and Mechanisms for Regulating Oxygen Affinity in Two Model Invertebrate Globins: The E7 Gate and Apolar Tunnel
… of the distal histidine (HisE7), which allows ligand migration into the distal portion of the heme pocket. This E7 gate pathway appears dominant in vertebrate Hbs and Mbs. However, a number of invertebrate globins, including the dimeric hemoglobin from the blood clam Scapharca inaequivalvis …
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Exploring Protein-Ligand Interaction with Rotamer-Library Based Refinement Tools
… been expanded to allow the inclusion of protein-ligand interactions by developing and evaluating methods for creating rotamer libraries for small drug-like molecules. Two algorithms have been developed that use these rotamer libraries to refine a series of protein-ligand interaction poses. A …
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Structure-Function Analysis of the EsaR N-terminal Domain
… that alter gene expression as a function of ligand detection. This coincides with a high population density and/or a low rate of signal ligand diffusion. The majority of LuxR proteins are activated only in the presence of the signal ligand, an acyl-homoserine lactone (AHL). EsaR, from the …