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Showing 1 to 20 of 425 for “"Ligand binding."”.
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Ligand Binding by Heme Proteins
Made available in DSpace on 2014-12-14T04:27:34Z (GMT). No. of bitstreams: 1 7606765.pdf: 4038449 bytes, checksum: 62e351e5367503c1cb5b9b986afaa009 (MD5) Previous issue date: 1975
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Computational Studies of Autocrine Ligand Binding
Autocrine ligand secretion and binding to cell surface receptors regulate cell behavior in a number of important physiological functions. At the same time, some pathological conditions such as the unmitigated growth of tumors can also act through this type of stimulation. Interpretation of …
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Heme protein structure and ligand binding
Binding of carbon monoxide to a variety of heme proteins is a multistep process and can be described by a sequence of activation barriers. In the separated alpha and beta chains of hemoglobin three barriers are found which are sensitive to the structural differences between the two chains. The …
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Thermodynamics of Ligand Binding to Glutamate Dehydrogenase
… investigation of the mechanism of allosteric ligand binding to GDH. During our computational investigation, we discovered a 40-year-old sequence error at the NADH/ADP/ECG binding site. Residue 387 was mistakenly identified as asparagine rather than the correct amino acid identity, lysine. The …
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General Features of Ligand Binding to Heme Proteins
The binding of ligands to heme proteins has been studied extensively in the past. A sequential barrier model was postulated. Using flash photolysis, various aspects of the model are studied in this work to give a better understanding of ligand binding. Binding from the pocket, as seen at low …
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Ligand Binding and Catalysis by Phosphoribosyl Pyrophosphate Synthetase
The binding of the substrates, ATP and ribose-5-phosphate (R5P), and the inhibitor ADP to phosphoribosylpyrophosphate (PRPP) synthetase from Salmonella typhimurium has been studied by equilibrium dialysis of these compounds labeled with ('32)P. The simplest model that fits the data is the …
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Ligand-Binding Properties of Escherichia Coli Pyruvate Oxidase
Made available in DSpace on 2014-12-13T20:10:33Z (GMT). No. of bitstreams: 1 7913567.pdf: 6615798 bytes, checksum: e50e91608fa1b94872aa9b0ce11516a0 (MD5) Previous issue date: 1978
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General features of ligand binding to heme proteins
Submitted by Carolyn Mead (cmead2@illinois.edu) on 2011-06-13T16:03:40Z No. of bitstreams: 1 1983_yue.pdf: 3097209 bytes, checksum: 7a7a4e29cd036d778a7bcba42024cde0 (MD5)
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Antibody active site contributions to fluorescein ligand binding
… with antigen) responsible for the observed Fl binding characteristics. To begin active site structure-function assessments, V$\sb{\rm H}$ and V$\sb\kappa$ primary structures were obtained. Except for 5-27 and 3-13, highly homologous V$\sb{\rm H}$III(C) genes were utilized. D region length and …
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Ligand Binding and Structural Dynamics in C-Type Cytochromes
… is proposed to be responsible for limiting the binding of cyt c to only one molecule per bc 1 dimer by altering the affinity of the cytochrome c binding site on the second cyt c1 monomer. A mechanism is also proposed explaining changes in cyt c binding affinity related to the position of the …
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Bacterial Luciferase: Studies of Proteolytic Inactivation and Ligand Binding
The mechanism of proteolytic inactivation of luciferase was examined. Proteolytic inactivation in vitro was found to be concomittant with: (1) the loss of enzymatic activity; (2) altered enzyme affinity for substrate and product; (3) changes in enzyme secondary structure; and (4) the fragmentation …
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Sialylation as a mechanism for preferential Ligand binding in CFS1R
… receptor can be activated by two non-homologous ligands, colony stimulating factor 1 (CSF1) and interleukin- 34 (IL-34). These two ligands are differentially required for macrophage homeostasis across body systems and have different associated pathologies. The ability to separately influence …
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Mapping Ligand Binding Sites in hERG1 Channel with Biomolecular Simulations
… approaches for mapping of potential drug binding sites in hERG1 and rapid assessment of drug blockade. In this thesis, first, we used free energy sampling methods to establish a connection between the cryo-EM structure of the hERG1 channel and its functionality. Furthermore, using the …
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Spectroscopic analysis and dynamics of ligand binding to bacterial oxidases
… of prosthetic groups and their reactions with ligands, as determined by a variety of spectroscopic methods.
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Investigation of an energetic coupling between ligand binding and protein folding
… mutase (dPGM) was identified as an ATP binding protein in a proteome-wide screen, but dPGM does not use ATP for catalysis. This dissertation elucidates the effect of ATP and other non-substrate metabolites on dPGM. Initial investigations revealed a partially unfolded, monomeric …
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COMPUTATIONAL APPROACHES FOR PROTEIN FOLDING AND LIGAND BINDING: FROM THERMODYNAMICS TO KINETICS
… simulations must be able to estimate the binding affinity and rates of association and dissociation of a protein-ligand complex, or the populations and rates of exchange between distinct conformational states (i.e. folding and unfolding, binding and unbinding). The above studies are …
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Lbpi: A Web Interface For The Identification of Allosteric Ligand Binding Sites
… development of efficient tools for allosteric ligand binding site identification in potential drug targets is an important step for computational drug design. Ligand binding specificity analysis (LIBSA) is one of the protocols that utilize filtering algorithms to assess the propensity of a site …
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Lbpi: A Web Interface For The Identification of Allosteric Ligand Binding Sites
… development of efficient tools for allosteric ligand binding site identification in potential drug targets is an important step for computational drug design. Ligand binding specificity analysis (LIBSA) is one of the protocols that utilizes filtering algorithms to assess the propensity of a …
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On the Role of Solvation in Ligand Binding: Structural and Thermodynamic Studies
… water molecules play a critical role in ligand binding. In spite of its fundamental thermodynamic impact, solvent energetics is often bypassed in virtual screening. On the one hand, the determination of water energetics is generally hampered by the cooperative nature of these …
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