Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Ligand Development"”.
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Transuranic Imidophosphorane Chemistry
… and Pr5+. This was achieved through strategic ligand development, where these imidophosphorane ligands helped to substantially cathodically shift the redox couples of the lanthanides, facilitating the isolation of these unique compounds. Herein, we present the expansion of this work to the …
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ELECTROCHEMICAL ORGANIC TRANSFORMATIONS: FROM THE DEVELOPMENT OF ENANTIOSELECTIVE STRATEGIES TO CONTINUOUS-FLOW METHODOLOGIES
… provide racemic products and motivate further ligand development for enantiocontrol. The second part focuses on scaling up the electrochemical Hofmann rearrangement of cyclic amides in continuous flow. Using NaBr as both electrolyte and bromine source, carbamates are accessed in almost …
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Synthesis of anticancer agents: 15-deoxy-15-fluoro-Δ12-prostaglandin J3 and gukulenin monomeric units
… natural and designed prostanoids, and the development of several landmark synthetic methodologies. Among the large family of PGs, a subclass known as the alkylidene-cyclopentenone prostaglandins (acyPGs) has been increasingly recognized for their prominent anticancer activities. In …
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Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase
… and provides structural insights to guide the development of small-molecule tools and potential drug leads. <br/><br/>Current structural information on SOCS2 is limited to apo form (no ligand bound). In the first part of the work, two novel SOCS2-ElonginB-ElonginC (SBC) structures in complex …