Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Lifespan extension"”.
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Optimizing Pharmacological Lifespan Extension: Testing Chemical Compounds for Additive Effects on Longevity
<p>No abstract available</p>
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Elucidation of the molecular pathways of lifespan extension by dietary restriction in yeast
… to show afg3∆ was within the Gcn4 pathway of lifespan extension, and finally bring nuclear tRNA and Gln3 into the light- showing that these could positively affect lifespan without reducing translation.
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Roles of the TORC1 Signaling in Stress Response and Chronological Lifespan Extension in Yeast
… findings indicate that CR extends the healthy lifespan at least in part through downregulating the conserved target of rapamycin complex 1 (TORC1) pathway. In Saccharomyces cerevisiae, enhanced mitochondrial ROS signaling and hyper-accumulation of storage carbohydrates are the two major models …
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Genetic Mechanisms Responsible for Dietary Restriction Dependent Lifespan Extension in Drosophila Melanogaster: A Role for Muscle Tissue
… is a robust intervention that is known to extend lifespan and increase spontaneous activity in multiple species. Whether activity increase plays a causal role in mediating the health protective benefits of DR remains unknown. To investigate this relationship, nutritional manipulations and …
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In Pursuit of a Molecular Fountain of Youth: The Identification and Characterization of Lifespan Regulators in Drosophila
Over the past century, average human lifespan has experienced steady increase despite lack of substantial intervention or understanding of the aging process. In fact, many organisms have the latent potential to live much longer than they normally do. This indicates lifespan determination is an …
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An investigation of the relationship between levels of apoptosis during aging and longetivity
… of apoptosis in muscle tissues results in lifespan extension. The magnitude of lifespan extension depends on the nature of the UAS-DIAP1 transgene. These results led to the working hypothesis that there might be an optimal level of apoptosis needed to maximally extend lifespan, and was …
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Direct selection on lifespan in Drosophila Melanogaster to elucidate the mechanisms of longevity
… well as the mechanisms and corollaries by which lifespan extension is achieved in semi-natural populations. With the advent of modern sequencing, and other -omics, technologies, selection experiments offer an exciting opportunity to investigate the molecular and genetic mechanisms of longevity. …
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Mechanistic Enzymology Of Plasmodium Falciparum Sir2, Structural And Biochemical Studies On Nicotinamidases And The Structure And Function Of Enzymes In The Purine Degradative Pathway From Klebsiella Pneumoniae
… enzymes that have been shown to have a role in lifespan extension in some organisms are presented. The Sir2 enzyme from the malaria-causing parasite Plasmodium falciparum is shown to be an NAD+-dependent deacetylase and an acetyllysinedependent and acetyllysine-independent NAD+ glycohydrolase. …
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The biology of ageing: pro- and anti-ageing signals from the reproductive system
… in later life, indicating a trade-off between lifespan and reproductive output. Ageing, however, is a complex genetic trait and strong interactions between genes that influence longevity and environment including with diet, stress and pharmacological factors have been discovered. Consistent …
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Investigation of the Role of TOR and Nutrient Restriction on Lifespan of Arabidopsis thaliana
… for the effects of reduced nutrients in the lifespan extension of plants. To study the role of TOR pathway in lifespan extension in Arabidopsis thaliana, mutant plants with reduced and overexpressed TOR activity were grown in hydroponic culture systems, to monitor the effects of varying …
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Toward a Quantitative Analysis of PARP-1 and Poly(ADP-ribosyl)ation in Cellular Senescence
… role of PARP-1 in nicotinamide-mediated cellular lifespan extension. Due to the challenges introduced by PAR's biochemical characteristics, successful mass spectrometric analysis of poly(ADP-ribosylation) will require the use of techniques to reduce the mass, charge, and heterogeneity of the …
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The Life History of Damaraland Mole-rats Fukomys damarensis: Growth, Ageing and Behaviour
… reproductive skew, status-related contrasts in lifespan and morphology, and the suggestion of a division of labour amongst helpers, mole-rat societies have repeatedly been likened to the structurally complex societies of some eusocial insects. However, because few studies of mole-rats have …
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Influences of nutrition and pathogenicity from a microbial diet on immunity and longevity in Caenorhabditis elegans
… neuroendocrine signaling pathway contributes to lifespan extension as a result of reduced nutrient availability in adulthood, commonly known as dietary restriction. Chapter Three explores how a bZIP transcription factor works to regulate the response to pathogenic bacteria downstream of p38 MAP …
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Establishing a role for specific nutrients in Drosophila dietary restriction
… robust and reproducible intervention to extend lifespan in diverse organisms ranging from yeast to mammals, including the fruit fly Drosophila. Despite over 70 years of research, primarily on rodents, the mechanisms by which DR extend lifespan in any organism are poorly understood, partially due …
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Time-Restricted Feeding Extends Longevity in Drosophila Melanogaster
… sleep behavior, tractable genetics, and short lifespan. We found that TRF extends longevity of fruit flies only in mated females, while showing no effect on mated males or virgin females. We measured the amount of food consumed by flies on TRF and confirmed that TRF does not act through caloric …
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How cellular ATP/ADP ratios and reactive oxygen species affect AMPK signalling
… to play a role in the innate immune response and lifespan extension in fruit flies. One way in which mitochondrial ROS may behave as a signal is by altering the activity of AMP-activated protein kinase (AMPK), a key metabolic sensor and regulator of cell metabolism, which is activated when …
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A genome wide approach to stress response and chronological ageing in yeast
Caloric restriction (CR) extends lifespan from yeast to mammals. In budding yeast, inhibition of the conserved TOR and/or PKA pathways has been shown to mediate lifespan extension by CR partly through the activation of stress response. However, how the stress response is regulated at the systems …
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Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
… antioxidant defence systems, and ultimately the extension of chronological lifespan. These starvation-induced phenotypes were at least partially mediated by three classes of transcription factors (TFs), including the general stress response factors Msn2/4, the post-diauxic shift factor Gis1 and …
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Natural genetic and phenotypic variation for aging
… genetic and metabolomic architecture underlying lifespan extension using a collection of 178 genetically variable Drosophila lines. In the second study, I introduce a novel model system for human aging and disease research, the companion dog, and demonstrate that dogs, like humans, show increased …
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The Role of Resveratrol and Sirtuin1 in Skeletal Muscle Under a Nutrient Stress
… nutritional manipulation that can increase both lifespan and healthspan in a variety of species. Underlying these increases are improvements in metabolic health and reductions in cancer incidence. Despite these physiological improvements, the regulation of skeletal muscle mass is extremely …
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