Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Lidocaine"”.
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A computational model for transdermal diffusion of lidocaine and tetracaine topical patches
In recent years, transdermal drug delivery patches (TDDP) have developed rapidly. This is because the TDD system has more advantages than traditional drug delivery systems such as oral medicine and intravenous injection. In order to reach the circulatory system of the human body, drug molecules …
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Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens
… these two procedures, along with reversible lidocaine-induced lesions of the N.Acc., to determine whether the N.Acc. is part of the extra-hippocampal system that subserves efficient memory-based foraging behavior. These lesions impaired performance on the spatial win-shift but not the cued …
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Serum concentrations of lidocaine and its metabolites after prolonged infusion in healthy horses
Lidocaine continuous-rate infusions (CRI) are the most commonly used prokinetic in equine practice for the treatment of post-operative ileus and are also increasingly being used in pain management, such as in cases of severe laminitis, and are often used for prolonged durations. To date only …
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Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers
… enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate (NHT) through the skin and mucosa was evaluated for potential clinical applications. These two potential delivery routes have the advantage of avoiding first-pass effect. Samples were pretreated …
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Human Nav1.5 F1486 deletion associated with long-QT syndrome leads to deficiency in inactivation and reduces lidocaine sensitivity
… which was refractory to antiarrhythmic drug lidocaine treatment. Therefore, it was hypothesized that the deletion of F1486 on Nav1.5 would substantially alter electrophysiological properties of the channel and reduce the potency of lidocaine on sodium channel. Using HEK293 cells and neonatal …
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The interaction of three local anaesthetic agents with hepatic microsomal cytochrome P-450
… metabolism of three local anaesthetic agents: lidocaine, mepivacaine and bupivacaine has been investigated. All three local anaesthetic agents bound to the type I binding site of cytochrome P-450, which is characteristic of substrate binding to cytochrome P-450, and stimulated the …
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Linker-based Lecithin Microemulsions as Transdermal Drug Delivery Systems
… and permeation of a common anaesthetic, lidocaine, was evaluated. The concept of “skin” permeability was introduced to account for the differences in solvent-skin partition when comparing different delivery systems. The linker-based lecithin microemulsion produced a substantial absorption …
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The Mechanism of Action of Lidocaine and Levobupivacaine on Human Cardiac Voltage-gated Na<sup>+ </sup>Channels Na<sub>V</sub>1.5
… adult and neonatal NaV1.5 splice variants. Lidocaine and levobupivacaine are amide local anaesthetics that are widely used in the clinic. They have different physiochemical properties and thus differ in their pharmacokinetic and pharmacodynamic profile. We compared the mechanisms of action …
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Needle Localization for Breast Biopsy: The Patient's Experience
… hospitals. The influence of eight variables (lidocaine, self-regulation, anxiety, worry about breast cancer, breast tenderness, finding mammography painful, difficulty with surgery, and distress of blood drawing) on four outcome variables (pain incidence, pain intensity, pain unpleasantness, …
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Accelerating development of treatments for trigeminal neuralgia using intranasal delivery and a novel behavioral screening device for rats.
… minimizing systemic exposure and side effects. Lidocaine was intranasally administered to rats, and the trigeminal nerve and trigeminally-innervated structures (teeth, temporomandibular joint (TMJ), and masseter muscle) accumulated up to 20-fold higher tissue concentrations of lidocaine than the …
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A Survey on the Usage of Articaine Among General and Pediatric Dentists
… than do pediatric dentists (28.1% versus 15.9%). Lidocaine with epinephrine was the local anesthetic that was most preferred in all age groups by all practitioners. Pediatric dentists preferred lidocaine more often than general dentists and general dentists preferred lidocaine without epinephrine …
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Mechanisms of rapid receptive field reorganization in rat spinal cord
… single unit recording. Subcutaneous injection of lidocaine into RFs of dorsal horn neurons results in expansion of their RFs within minutes. The expanded RFs appear adjacent to or/and proximal to original RFs. Out of 63 neurons tested, 36 (58%) show RF reorganization. The data suggest that dorsal …
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The effect of nucleus reuniens inactivation on neocortical K-complex and hippocampal sharp wave-ripple correlations
… and KC coordination. I found that dialysis of lidocaine into reuniens did not affect the coordination of KCs and SPWRs. While previous studies have demonstrated effective local neural inactivation using lidocaine dialysis, I did not observe any effects that could be used to positively verify a …
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Amelioration of oxidative lung injury by antiarrhythmic agents
Class I antiarrhythmic drugs, such as lidocaine, quinidine and procainamide, are known to be effective membrane stabilizers. However, the mechanism of such "membrane stabilization" has not been elucidated. In the present study we found that all three drugs are powerful scavengers of hydroxyl! …
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Local Anesthetics in Post-Operative Endodontic Pain
… an intermediate-acting local anesthetic (2% lidocaine with 1:100,000 epinephrine) or a long-acting local anesthetic (0.5% bupivacaine with 1:200,000 epinephrine). Twenty-one patients in need of emergency non-surgical endodontic treatment were included in this study. The first stage of …
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Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis
… Overall incidence of FIC was approximately 31%. Lidocaine [odds ratio (OR) = 0.29, 95% confidence interval (CI) 0.21 – 0.39], N-methyl-D-aspartate (NMDA) receptor antagonists [OR = 0.09, 95% CI 0.02 – 0.42], propofol [OR = 0.07, 95% CI 0.01 – 0.36], α2 agonists [OR = 0.32, 95% CI 0.21 – 0.48], β2 …
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Improving Outcomes for People Living With Unrelieved Neuropathic Cancer Pain - Understanding the Epidemiology, Patient Experience and Optimal Clinical Trial Design: The INCEPT Mixed Methods Project
… pain, and a pilot randomised controlled trial of lidocaine infusion with an embedded semi-structured interview sub-study of trial feasibility and acceptability. Mid-study and end-study meta-inferences integrated the results. 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀 Distress from unrelieved neuropathic cancer pain is commonly …
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Oscillating Aqueous Gels as Drug Delivery Systems
… similar weight proportions to act as controls. Lidocaine and lidocaine/prilocaine eutectic mixture were selected as the model drug components. Optical and polarized light microscopy images were used to determine the structure and texture of each aqueous gel, and they have indicated cubic liquid …
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