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Showing 1 to 20 of 21 for “"Leydig Cell"”.
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Molecular Genetics of Endocrine Induced Regression of Mouse Leydig Cell Tumors
… estrogen treatment results in malignant Leydig cell tumor formation in genetically susceptible strains of mice. The hypothesis that the mechanism of estrogen induced carcinogenesis includes a gene amplification event was tested using this<em> in vivo</em> endocrine carcinogenesis model. …
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Effects of Estradiol on Leydig Cell Function and Testicular Development in the Prepubertal Bull
… of the testes and assessment of in vitro Leydig cell function. Serum E$\sb2$ was greater than 100 pg/ml in all calves at birth but decreased to lower basal levels by day 7 in P and PH. Whereas serum testosterone (T) was observed to rise immediately following birth and remain elevated in P …
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Mechanisms by which hypoxia augments Leydig cell viability and differentiated cell function in vitro
… peptide in the testicular interstitial cells. Leydig cells, which comprise up to 80% of the testicular intertubular cell population, are known to synthesize testosterone in situ. Indirect evidence indicated that an oxytocin-like peptide was also present in Leydig cells. The question …
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The MA-10 Cell Line as a Model of insl3 Regulation and Leydig Cell Function
<p>Leydig cells produce testosterone in response to luteinizing hormone (LH) via the cyclic adenosine monophosphate (cAMP)/protein kinase A pathway. Additionally, these cells are responsible for producing insulin-like peptide 3 (INSL3), a peptide hormone that is essential for testicular descent. …
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Pathophysiology of Small Testes in Beef Bulls: Histopathological Features of Testes and Epididymides, Seminal Characteristics, and Endocrine Profiles (Testicular Hypoplasia, Degeneration, Breeding Soundness, Scrotal Circumference)
… gonadotropins suggested that the impairment in Leydig cell structure and function was caused by local factors, either the factors that caused the tubular damage or those consequent to the tubular damage. Hence, Leydig cell failure in these bulls may not be the primary cause of germinal …
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Regulation of Expression of 5 Alpha-Reductase Type 1 in Mouse Leydig Cells
… present in the immature (prepubertal) testicular Leydig cells when androstanediol is their principal product. The high testosterone production by the fetal and adult mouse testis is driven by human chorionic gonadotropin and luteinizing hormone, respectively, which act through elevation of …
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Effects of Zeranol on Some Reproductive Traits in Beef Bulls (Semen, Histology, Hormones)
… and suppressed synthesis of testosterone by Leydig cells in response to GnRH-induced release of LH and hCG. However, pituitary and Leydig cell function recovered from the effects of zeranol in a similar manner in both implanted groups with increasing age. Zeranol also reduced testicular …
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Expression of perforin and granzyme variants in adult rat testes after ethylene dimethane sulfonate (EDS)-induced testosterone depletion
… and testosterone withdrawal results in germ cell apoptosis. However, the mechanism for germ cell apoptosis is unknown. In testes, mature Leydig cells produce testosterone. Using ethane dimethane sulfonate (EDS), a Leydig cell-specific toxicant, to deplete testosterone, we investigated the …
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EFFECT OF CONSTITUTIVELY ACTIVATED LUTEINIZING HORMONE RECEPTOR ON THE MOUSE REPRODUCTIVE SYSTEM
… for the Doctor of Philosophy degree in Molecular Cellular and Systemic Physiology, presented on 11th December, 2015 at Southern Illinois University Carbondale. TITLE: EFFECT OF CONSTITUTIVELY ACTIVATED LUTEINIZING HORMONE RECEPTOR ON THE MOUSE REPRODUCTIVE SYSTEM MAJOR PROFESSOR: Dr. Prema Narayan …
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Interaction of Putative Estrogens and the Estrogen Receptor System in Leydig Cells in the BALB/c Mouse Testis Resulting in the Initiation of DNA Synthesis
… mice, leads to the formation of testicular Leydig cell tumors. Three days following the subcutaneous implantation of a pellet of estrogen in cholesterol, there is a peak in the incorporation of <sup>3</sup>H-tymidine into the DNA of the interstitial cells. These effects are hypothesized to …
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A Review of Perfluorooctanoic Acid Carcinogenicity and Application to Human Risk
… a tumor triad consisting of liver adenomas, Leydig cell adenomas and pancreatic acinar cell tumors in male Spraque-Dawley rats. The ability of PFOA to produce tumors in rodents compounded by the fact that PFOA is accumulating not only in those occupationally exposed, but also in the general …
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The role of retinoic acid in germ cell development in embryonic mouse gonads
Germ cells are the only cell type to undergo meiosis, a specialized cell division process necessary for the formation of haploid gametes. Timing of this process is sex-specific. Ovarian germ cells initiate meiosis during embryonic development, while testicular germ cells initiate meiosis after …
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Characterization of MC3 and the other melancortin receptors (MC) in the hypothalamo-pituitary-gonadal system of the mouse
… on nitrite release was also apparent in the K9 Leydig cell line, which expresses all five isoforms of MC. MC3 may be both directly and/or indirectly implicated in the control of the mouse HPG system. The anti-inflammatory action of testicular MC3 activation could lead to possible clinical …
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The activin a pathway in fetal testis development and dysgenesis in the mouse
… activin A can elicit changes in target cell proliferation, differentiation, and function via the SMAD signaling pathway. Inhibin βA (Inhba), the gene encoding activin A, is expressed within the interstitial compartment of murine and human fetal testes; however, the role of Inhba/activin …
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Role of androgens in testicular development and dysgenesis
… or in young adulthood (testicular germ cell cancer and low sperm counts), are common and may be increasing in incidence. These disorders have a common fetal origin and share risk factors; consequently they are hypothesized to comprise a testicular dysgenesis syndrome (TDS). TDS arises …
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Characterization of Residual Ovarian Tissue in Mice following 4-vinylcyclohexene Diepoxide-induced Ovarian Failure
… mice that received DMBA developed Sertoli-Leydig cell tumors while no tumors were observed in cycling animals. Residual ovarian tissue following ovarian failure appears to have a protective effect against loss of bone integrity, but a detrimental effect on development of ovarian neoplasms. …
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Neonatal estrogen and androgen disrupted sertoli cell proliferation, leading to inhibited testosterone synthesis in adulthood
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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CLINICAL VALIDATION OF 371 MICRO-RNA USE IN SMALL TESTICULAR MASSES AND IN STAGE IIA AND IIB<3CM TESTICULAR GERM CELL TUMORS
Background and Objectives Testicular Germ-cell Tumour (TGCT) is the most frequent tumour in the young male and its occurrence is increasing in Europe. Prognosis is favourable, and TGCT basically represents a model of curability of solid tumours. However, clinical management and follow-up of both …
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The effects of green tea, green rooibos and their major flavonoids (EGCG and aspalathin) on testicular cell health in vitro
… male sex steroidogenesis and of spermatogenesis. Leydig cells, located at the testicular interstitium, produce predominantly testosterone upon stimulation with either chorionic gonadotropin (CG) or luteinising hormone by a series of enzymatic modifications of cholesterol. Sertoli cells respond to …
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Dietary tomato carotenoids and β-carotene-15,15'- dioxygenase (Bco1) genotype alter androgen metabolism, lipid metabolism, and prostate cancer progression in mice
… a testicular steroidogenic gene (Hsd17b3) and/or Leydig cell populations. Concomitantly, we observed reductions in markers of androgen signaling, proliferation, and cell cycle progression in the prostate. Together, these data support a hypothesis that Bco1-/- mice exhibit reduced testicular …
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