Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Lewy body"”.
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Lewy Body Dementia and the Role of Inflammation
Background: Lewy body dementia (LBD), consisting of Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), is known to make up more than 15% of dementia cases at autopsy, however the clinical prevalence rate is reported to be much lower at around 5-6%. Difficulties with diagnosis …
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Anatomy of visual hallucinations and fluctuations of consciousness in Lewy body diseases
Lewy body diseases are characterized by parkinsonian disorders of movement and neuropsychiatric features of dementia, visual hallucinations and altered states of consciousness. The underlying neurobiological changes responsible for the psychiatric features are poorly understood. The integrative …
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Solid-state NMR structural investigations of alpha-synuclein fibrils derived from Lewy Body dementia brain tissue
… feature of neurodegenerative diseases, including Lewy Body dementia (LBD), Parkinson’s disease (PD), and multiple system atrophy (MSA). Despite this fact, there is currently no way to detect or quantify these fibrils in living patients, which could significantly improve diagnosis and treatment …
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The Influence of Age, Gender, and Thiol Repletion in an In Vivo Model of Lewy Body Disorders
<p>Lewy body disorders are a family of neurological brain disorders associated with olfactory, motor, and cognitive deficits and are collectively defined as α-synucleinopathies, as they are characterized by hallmark “Lewy bodies” composed of aggregated, fibrillar α-synuclein. It is not certain but …
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Adapting Behavioral Interventions to Better Support Alzheimer's Disease and Lewy Body Dementia Care Partners Based on Their Unique Needs and Differences
… of individuals with Alzheimer's disease (AD) and Lewy body dementia (LBD) are typically family members or friends. They often experience physical and psychological strain associated with caregiving. Hence, the long-term goal is to improve the physical and psychological health and well-being of …
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Substrate Selection by the 20S Proteasome and Implications in Disease Pathogenesis
Alpha-synuclein is a major component of Lewy bodies, large insoluble protein aggregates, found in various regions of the brain in patients with Parkinson’s disease, diffuse Lewy body disease, and the Lewy body variant of Alzheimer’s disease. Within Lewy bodies, several modifications of …
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Histamine H3 Receptor Heterogeneity in the Central Nervous System in Aging and Dementia.
… and H3 329 isoforms in Parkinson’s disease and Lewy Body Dementia cases, respectively, compared to age-matched controls. We have shown a variety of H3R ligands display differential pharmacological properties at the three hH3R isoforms expressed in HEK 293 cells. Most notably a 5- and 10- fold …
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A deep dive into the liquid droplet state of α-synuclein
… disease (PD) is characterised by the presence of Lewy bodies, aggregates primarily composed of misfolded α-synuclein. Despite extensive research, the precise relationship between α-synuclein aggregation and Lewy body formation remains elusive. This study investigates the dynamic process of …
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HISTAMINERGIC H3 AND CANNABINOID CB1 RECEPTORS IN DEMENTIA
… of CB1 receptors in postmortem brain samples of Lewy body dementia patients indicate the possible relationship between CB1 loss and amyloid plaque burdens as well as synaptic deficits. Furthermore, the effect of CB1 inverse agonists suppressing the non-amyloidogenic APP cleavage mediated by …
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The role of germline and somatic nuclear and mitochondrial DNA variation in neurodegenerative disorders
… increase the risk of developing dementia with lewy bodies (DLB) and Alzheimer’s disease (AD) respectively. Secondly, we detected a previously unknown systematic bias in the interpretation of oligogenic interactions with implications for our understanding of disease mechanisms and coexistent …
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MODELLING GBA1-RELATED PARKINSON¿S DISEASE PATHOLOGY IN PATIENT-DERIVED MIDBRAIN ORGANOIDS
Aggregation of α-synuclein protein in “Lewy bodies” and “Lewy neurites” and dopaminergic neuronal loss in the nigrostriatal system are the key neuropathological hallmarks of Parkinson’s disease. Mutations in GBA1, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s …
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Multi-omic Analysis of Neurodegeneration in Alzheimer’s Disease and Related Dementias
… Disease (AD), Frontotemporal Dementia (FTD), Lewy Body Dementia (LBD), and Vascular Contributions to Cognitive Impairment and Dementia (VCID). We utilize both single-cell RNA sequencing (scRNA-seq) and single-cell ATAC sequencing (scATAC-seq) to perform a joint analysis of these conditions, …
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Neuropathological findings and staging in dementia
… generally indicates the diagnoses Lewy body disease (LBD) or AD among the demented, while a preserved locus coeruleus occurs mainly in VaD and frontotemporal lobar degeneration (FTLD). Moreover, various neuropathological staging systems for AD differ in procedure and targeted …
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Genetic determinants of cognitive heterogeneity in Parkinson’s disease
… gene (GBA) mutations contribute to widespread Lewy body (LB) pathology and are associated with a younger age of onset, severe disease progression, and a higher risk of dementia. In order to investigate cognitive disturbances within GBA-PD, two statistical methods specifically developed for …
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Implications of Advanced Glycation Endproducts in Oxidative Stress and Neurodegenerative Disorders
… tangles (NFT) associated with AD and in the Lewy bodies characteristic of PD. Increasing evidence supports a role for oxidative stress in neurodegenerative disorders such as AD and PD. AGEs have been shown to contribute towards oxidative damage and chronic inflammation, whereby activated …
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Metabolism of Alpha-Synuclein by the 20S Proteasome
… data support a role for the 20S proteasome in Lewy body disease pathogenesis, where it accelerates the formation of cytotoxic species by endoproteolysis of an intrinsically disordered protein. In that regard, a form of the 20S proteasome was identified that may be responsible for the …
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Studies on the Cytoplasmic Inclusions Detected in Parkinson's disease
… Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Synphilin-1, interaction partner of α-Synuclein is a major component of inclusion bodies, but it is unknown how synphiln-1 contributes to the cellular and biochemical mechanisms of PD, and its …
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The impact of delirium on cognitive outcomes in population-based studies
… not accounted for by Alzheimer’s, vascular or Lewy body pathology. (4) The chart abstraction method yielded a sensitivity of 0.88 and specificity 0.75 for ‘possible delirium’, with lower sensitivity (0.58) and higher specificity (0.93) for ‘probable delirium’ (AUC 0.86, 95% CI 0.82 to 0.89). …
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Synthetic and Natural Environmental Compounds as Potential Facilitators of Mptp-Induced Parkinsonism
Parkinson's disease (PD) is a neurodegenerative Lewy body disorder characterized by severe motor deficits, followed by cognitive dysfunction with progression of the disease. Environmental exposure has been suggested as a possible contributor to the development of PD and this view is linked to the …
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Dementia with Lewy bodies —an Investigation of Cause and Consequence
Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are …
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