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Showing 1 to 20 of 94 for “"Lewy"”.
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Lewy Body Dementia and the Role of Inflammation
Background: Lewy body dementia (LBD), consisting of Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), is known to make up more than 15% of dementia cases at autopsy, however the clinical prevalence rate is reported to be much lower at around 5-6%. Difficulties with diagnosis …
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Dementia with Lewy bodies —an Investigation of Cause and Consequence
Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are …
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Anatomy of visual hallucinations and fluctuations of consciousness in Lewy body diseases
Lewy body diseases are characterized by parkinsonian disorders of movement and neuropsychiatric features of dementia, visual hallucinations and altered states of consciousness. The underlying neurobiological changes responsible for the psychiatric features are poorly understood. The integrative …
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The Role of β-synuclein in the Pathological Mechanisms of Dementia with Lewy Bodies
Dementia with Lewy bodies (DLB) is the second most prevalent neurodegenerative dementia following Alzheimer’s disease (AD). DLB neuropathology is characterised by Lewy bodies (LBs) and Lewy neurites (LNs) resulting from the modification and aggregation of α-synuclein. The presence of small …
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Alzheimer's disease and dementia with Lewy bodies: Special focus on the role of serpins
… Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). The pathological characteristics of AD include senile plaques, mainly composed of aggregated amyloid-beta peptide (Abeta1-42), but also serpins, and neurofibrillary tangles of hyperphosphorylated tau protein. Pathological …
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Individuelle Leistungsprofile in Screening-Verfahren zur Demenzdiagnostik bei Alzheimer-, Morbus Parkinson- und Lewy-Körperchen-Erkrankten
… bei Morbus Parkinson, Alzheimer-Demenz sowie Lewy-Körperchen-Demenz. Bei Betrachtung der Ergebnisse kann ganz allgemein festgestellt werden, dass sich durchaus Unterschiede in den Leistungsprofilen der einzelnen Krankheitsgruppen finden lassen. Die eindruckvollsten Unterschiede zeigen sich …
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Validation of brief cognitive tests in mild cognitive impairment, Alzheimer's disease and dementia with Lewy bodies.
… with AD. II. 33 patients with dementia with Lewy bodies (DLB) and 66 with AD. III. 75 patients with AD. IV. 99 patients with mild cognitive impairment (MCI). Findings I. Cube copying was found useful for evaluating treatment with acetylcholinesterase inhibitors (AChEI) in patients with AD. …
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Solid-state NMR structural investigations of alpha-synuclein fibrils derived from Lewy Body dementia brain tissue
… feature of neurodegenerative diseases, including Lewy Body dementia (LBD), Parkinson’s disease (PD), and multiple system atrophy (MSA). Despite this fact, there is currently no way to detect or quantify these fibrils in living patients, which could significantly improve diagnosis and treatment …
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The Influence of Age, Gender, and Thiol Repletion in an In Vivo Model of Lewy Body Disorders
<p>Lewy body disorders are a family of neurological brain disorders associated with olfactory, motor, and cognitive deficits and are collectively defined as α-synucleinopathies, as they are characterized by hallmark “Lewy bodies” composed of aggregated, fibrillar α-synuclein. It is not certain but …
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Differential expression of proteins involved in sEV biogenesis and secretion in Parkinson’s disease and Dementia with Lewy bodies
… Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).<br/><br/>Aims<br/>1. In this study I aim to measure levels of key sEV proteins by focusing on disease-specific brain regions such as the substantia nigra and hippocampus of patients with PD and DLB compared to healthy control …
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A study of ultra-high field strength structural and spectroscopic MR imaging in dementia with Lewy bodies and Alzheimer’s disease
… of neurodegenerative dementia, dementia with Lewy Bodies (DLB) is relatively poorly understood, with little research focusing on its pathophysiology or symptomatology in comparison with Alzheimer’s disease (AD) or Parkinson’s disease (PD), to which it is closely related. In contrast to AD, …
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Early hippocampal dysfunction in a mouse model of dementia with Lewy bodies: Mechanisms of cellular dysfunction caused by alpha-synuclein accumulation
Dementia with Lewy bodies (DLB) is a devastating neurodegenerative disease, accounting for 5% of all dementia cases, for which there is no cure. Whilst there are currently many different animal models currently available for researchers studying PD, there are comparatively fewer DLB-specific mouse …
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Substrate Selection by the 20S Proteasome and Implications in Disease Pathogenesis
Alpha-synuclein is a major component of Lewy bodies, large insoluble protein aggregates, found in various regions of the brain in patients with Parkinson’s disease, diffuse Lewy body disease, and the Lewy body variant of Alzheimer’s disease. Within Lewy bodies, several modifications of …
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Adapting Behavioral Interventions to Better Support Alzheimer's Disease and Lewy Body Dementia Care Partners Based on Their Unique Needs and Differences
… of individuals with Alzheimer's disease (AD) and Lewy body dementia (LBD) are typically family members or friends. They often experience physical and psychological strain associated with caregiving. Hence, the long-term goal is to improve the physical and psychological health and well-being of …
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MODELLING GBA1-RELATED PARKINSON¿S DISEASE PATHOLOGY IN PATIENT-DERIVED MIDBRAIN ORGANOIDS
Aggregation of α-synuclein protein in “Lewy bodies” and “Lewy neurites” and dopaminergic neuronal loss in the nigrostriatal system are the key neuropathological hallmarks of Parkinson’s disease. Mutations in GBA1, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s …
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Impact of N-Acetyl-L-Cysteine on the Pathology of Experimental Parkinson’s Disease in Vivo
… and hallmark proteinaceous inclusions known as Lewy bodies in multiple brain regions spanning the medulla oblongata to the telencephalon. There are no therapies that decelerate the progression of this disease. Thus, the major goal of the present study was to test the therapeutic potential of two …
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A deep dive into the liquid droplet state of α-synuclein
… disease (PD) is characterised by the presence of Lewy bodies, aggregates primarily composed of misfolded α-synuclein. Despite extensive research, the precise relationship between α-synuclein aggregation and Lewy body formation remains elusive. This study investigates the dynamic process of …
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The role of Galectin-3 in the pathogenesis of Parkinson's Disease
… características de la EP llamadas Cuerpos de Lewy. Junto a la aparición de estos Cuerpos de Lewy, la EP se caracteriza por la degradación específica de la substancia nigra, un área dopaminérgica del mesencéfalo cerebral involucrada en el control del movimiento. En la actualidad, las diversas …
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Investigating the Potential Role of α-Synuclein in Tau Aggregation and Toxicity
… abnormal aggregation of α-Synuclein (α-Syn) in Lewy bodies (LBs) and Lewy neurites (LNs), are collectively known as synucleinopathies. Even so, tau protein pathology is abundantly found in these diseases. Apart from Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system …
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