Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Lewis lung Carcinoma"”.
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C/EBPβ Regulates Tumour Size and Microenvironment Composition in Lewis Lung Carcinoma
… across different cancer types, its role in lung cancer, particularly in the widely used Lewis lung carcinoma (LLC) model, remains poorly defined. The objective of this study was to define the role of C/EBPβ in LLC tumour progression and to characterize how C/EBPβ shapes the tumour …
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Enhancement of Antitumor Activities of a Selective Cyclooxygenase-2 Inhibitor, Celecoxib on the Lewis Lung Carcinoma that Express Cyclooxygenase-2
… mice were injected subcutaneous with 1 x 106 Lewis Lung Carcinoma(LLC) cells. Animals were randomized to one of six groups: no treatment(group 1), celecoxib 25mg/kg daily per oral intake alone(group 2), celecoxib 75mg/kg daily per oral intake alone(group 3), 10 Gy irradiation alone in one …
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The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion
… multiple murine tumor models, including Lewis lung carcinoma, which elicit an optimal or attenuated TCR signal in CD8 T cells. Longitu- dinal phenotyping and single-cell transcriptomics of tumor-specific T cells revealed that formation and maintenance of the Tpex reservoir in …
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Potential Mechanisms Explaining the Antitumor Effect of Total-Body Irradiation
… TBI produces an antitumor effect in the Lewis lung carcinoma (EEC) model, the major goal of this study was to determine whether changes in tumor growth could be correlated with radiation-induced alterations of immune system parameters. The governing hypothesis was that selective immune …
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The Suppressive Mechanisms of TIM3 on T Cell Cytokine Production and The Anti-Tumor Effect of TIM3-Pathway Inhibition
… Tim3-hIg. The tumor growth in mice injected with Lewis lung carcinoma (3LL) cells was suppressed and the frequencies of CD4+CD25+Foxp3+ T cells were reduced. Furthermore, injection of Tim3 pathway inhibitor expressing cells significantly enhanced the efficacy of a prophylactic tumor vaccine and …
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Comparative Plasma Proteomics in Muscle Atrophy Induced by Cancer Cachexia and Hindlimb Unloading
… mice were assigned to hindlimb unloading (HU), Lewis Lung Carcinoma (LLC), or control groups. HU animals were hindlimb-unloaded for 1 week to induce disuse atrophy. LLC cells were injected into the right hind-flank to induce cancer cachexia. Tumors developed for approximately 4 weeks. …
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The role of Protein Degradation in Cancer Cachexia in Female Tumor Bearing Mice
… focused on the late stages of CC. Methods: Lewis Lung Carcinoma (LLC) was injected into C57BL6/J mice into their hind flank at 8 weeks of age. The tumor was allowed to develop for a LT and HT group and was compared to a PBS control. Results: Tumor weight was significantly higher in HT mice …
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Sex Differences in Cancer Cachexia and a Novel Mitochondrial Target for Cancer-Induced Muscle Wasting
… mice were given either an IP injection of PBS or Lewis Lung Carcinoma (LLC) injection and the tumors were allowed to grow for 1, 2, 3, or 4-wk to assess the time course of cachectic development. We found a dichotomous effect on tumor mass between 3- and 4-wk animals where approximately half of …
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Ionizing Radiation and Endostatin Gene Therapy Against Lung Tumor
… significantly greater anti-tumor effect against lung carcinoma than either modality alone. The underlying mechanisms were postulated to include alterations in the balance of cytokines critical for generating tumor vasculature.</p> <p>pXLG-mEndo, the unique plasmid containing a mouse endostatin …
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Sex-Based Differences in ACVR2B and GRB10 Expression in Skeletal Muscle During Induced Cancer Cachexia and Disuse
… atrophy in male and female mice. Methods: Lewis Lung Carcinoma (LLC) was injected into the hind flank of male and female C57BL6/J mice at 8 weeks of age. Tumors were allowed to develop for 1, 2, 3, or 4 weeks and were compared to a PBS control. Disuse-induced male and female C57BL6/J mice …
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Characterisation of the effect of electroporation and electrochemotherapy on cancer cells and immune cells in the tumour microenvironment
Lung cancer is the leading cause of cancer-related death worldwide, with the lung cancer incidence rate expected to rise further. Despite recently developed novel therapy options, 5-year survival rates for lung cancer patients remains below 20% generally and below 5% for late-stage diagnosis, thus …