Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Levodopa"”.
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Effect of Levodopa on EEG Connectivity in Parkinson's Patients
Levodopa is a dopamine replacement medication administered to patients with Parkinson’s disease (PD) to alleviate their motor symptoms. However, its long-term use can cause adverse side effects, including involuntary motor movements. We studied 16 PD patients before and after taking Levodopa based …
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Evaluating the relationship between motor symptoms and Levodopa dosage in Parkinson’s disease
… measured through the MDS-UPDRS Part III, and Levodopa Equivalent Daily Dosage (LEDD), measured with daily Sinemet immediate-release dosages. The intent of this study was to find commonalities between patients to provide more concrete progression and treatment guidelines. From this comparison, …
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Two Sides of The Same Coin in The Levodopa Treatment of Parkinson's Disease
… in the pars compacta of the substantia nigra. Levodopa (L-dopa) and dopamine agonists have been most commonly used for symptomatic treatment. Since its initial introduction in 1967, L-dopa has been shown to be the most effective pharmacological agent. Thus, L-dopa has been regarded as the gold …
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Novel sustained release formulation of leveodopa-dendrimer conjugate
… to potentially alleviate these disease symptoms. Levodopa is the current drug of choice for the treatment of PD. The effectiveness of any investigative PD drug is compared with that of levodopa. However, its dose needs to increase with chronic use and there are some side effects like nausea and …
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Causal Inference and Machine Learning Methods in Parkinson's Disease Data Analysis
… causal inference method assessing the Carbidopa-Levodopa effect on two-year survival and a causal survival analysis on a one-to-five-year survival comparing no drug use and Carbidopa-Levodopa in Parkinson’s Disease patients.</p> <p>For my classification with Parkinson’s gait, patients were …
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Caratteristiche neurofisiologiche della Malattia di Parkinson de novo: dalla diagnosi al trattamento.
… Cortico-basale. La risposta terapeutica alla levodopa è espressa da due differenti modalità: la risposta di breve durata (SDR) e la risposta di lunga durata (LDR). La LDR deriva da una prolungata somministrazione di levodopa nella MP. Modelli animali supportano l’ipotesi che la LDR è …
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Meccanismo d'azione del Pramipexolo nella terapia della malattia di Parkinson
… agonist widely used alone or in combination with levodopa as Dopamine Replacement Therapy in Parkinson’s disease. In clinical and preclinical studies, PPX improved motor deficits, this evidence led to lowering daily dose of levodopa, delaying the motor side effects associated with its use. …
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Phytochemical Investigation of Psychoactive Medicinal Plants for the Treatment of Neurological Disorders
… non-dopaminergic drugs can better alleviate levodopa-induced motor complications along with better control of motor symptoms. MAO-B inhibitors play a significant role in dopamine (DA) metabolism and can be used as monotherapy in the early stages of PD, or in combination with levodopa. …
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Rehabilitation Engineering in Parkinson's disease
… and how these mechanism are affected by levodopa; 2) develop and validate a protocol, using wearable inertial sensors, to measure postural sway and postural transitions prior to step initiation; 3) find quantitative measures sensitive to impairments of postural control in early stages of …
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Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei
… activity. Of the 96 tested, two (Azaserine and Levodopa) were investigated in more detail, paying special attention to the nature of their trypanocidal action and possible route of entry through an amino acid transporter. Azaserine showed a trypanostatic action as well multiple routes of entry …
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Development of Binary Composite Solid Microparticles for Improved Intranasal Absorption of Low Permeation Drug Molecules
… delivery of two low permeation candidates: levodopa (L-DOPA; antiparkinsonism drug) and ribavirin (RBVN; an antiviral drug). The central hypothesis states that preparation of binary composite microparticles with Pluronic® triblock copolymers (polyethylene glycol-polypropylene …
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The Effects of Socioeconomic Status on the Progression of Parkinson’s Disease
… Wake Forest Baptist Medical Center (WFBMC). The Levodopa Equivalent Daily Dose (LEDD) was calculated for high (N=50) and low (N=50) SES cohorts at their first available visit in the medical records, denoted as baseline, and a one-year follow up visit. These values were then compared for each …
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Wireless Sub-Cellular Sized Stimulators for Minimally Invasive Deep Brain Stimulation with High Spatiotemporal Resolution
… treatment (such as tremor) or are caused by it (levodopa-induced dyskinesia). However, current DBS technology comes with inherent limitations and problems, including: 1) the need of a large invasive foreign body (the electrode) which can cause lead infections, 2) low coverage of entire …
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The Type IV Pilus Assembly ATPase PilB as a Regulator of Biofilm Formation and an Antivirulence Target
… led to the identification of benserazide and levodopa as CtPilB inhibitors. We show that both compounds inhibit T4P assembly in M. xanthus without any detrimental effects on bacterial growth. Furthermore we demonstrate that both levodopa and benserazide inhibit T4P-mediated motility in …
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Parkinsonian Speech and Voice Quality: Assessment and Improvement
… collected from 51 PD patients, on and off the Levodopa medication, and 7 control subjects. Features extracted from the sustained vowel recordings were combined using linear regression (LR) and support vector regression (SVR). An objective metric that combined linear prediction and harmonicity …
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Expectation, the placebo effect and Parkinson's disease : an investigation using high-resolution positron emission tomography
… to investigate how the likelihood of receiving levodopa influenced dopamine release when the patients were in fact given placebo. Placebo-induced dopamine release was differentially modulated by expectation in the dorsal and ventral striatum: dopamine release in the putamen was related …
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The Role of the Cortico-Basal Ganglia-System in Voluntary Movements
… motor control is impaired. Here we found that levodopa induced-dyskinesia was tightly associated with a strong oscillatory phenomenon in the motor cortex, and that stopping the oscillation locally was sufficient for alleviation of motor symptoms. By expanding the neuronal recordings using the …
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Manejo terapéutico y adherencia al tratamiento farmacológico en pacientes con Enfermedad del Parkinson.
… entre el resto de los medicamentos, siendo la levodopa el más empleado para tratar esta enfermedad.
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Studio di formulazione e caratterizzazione di nanoparticelle a base di trimetil chitosano e sodio alginato per il rilascio mirato di farmaci
… brain drug delivery, progesterone (PG-NPs) and levodopa (LD-NPs), at different concentrations. Indeed, recent developments have proved the possibility of using the nasal pathway for direct transport of drugs from nose to brain. Both PG-NPs and LD-NPs have positive zeta potential (~ + 30 mV) and …
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Effect of Cigarette Smoking on Disease Progression in Idiopathic Parkinson's Disease Patients
… duration (5.3 yrs Vs. 4.8 yrs, p=0.344), and levodopa dosage (616.8 mg Vs. 572.9 mg, p=0.583) were similar between the smoker group and non-smoker group. However, the age of IPD onset (57.3 yrs Vs. 63.5 yrs, p=0.047), UPDRS motor scores (14.8 Vs. 19.1, p=0.034), particularly the akineto-rigid …
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