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Showing 1 to 12 of 12 for “"Leukotriene B4"”.

  1. Leukotriene B4-activated human endothelial cells promote transendothelial neutrophil migration

    Nohgawa, MasaharuKyoto University1999

    kyoto Repository record

  2. Role of the Leukotriene B4 Metabolic Pathway in Human Pancreatic Cancer

    Tong, WeigangCreighton University2002

    … apoptosis in human pancreatic cancer cells.|Leukotrienes constitute a class of potent biological mediators of inflammation and anaphylaxis. Among them, leukotriene B4(LTB4) is one of the final products of the 5-LOX pathway of arachidonic acid metabolism and it has been widely implicated in …

    creighton Repository record

  3. Development and application of monoclonal antibodies in studies of the human leukotriene B4 receptor, BLT1

    Pettersson, AnnikaDepartment of Physiological Sciences, Lund University2005

    … system. One of these important mediators is LTB4, an arachidonic acid derivate that attracts e.g. monocytes and granulocytes to inflammatory sites and induces phagocytosis and degranulation. LTB4 binds to BLT1 which is a 7-transmembrane receptor that belongs to the superfamily of G …

    lund Repository record

  4. cell motility and machine learning

    Yu, GuangyuanRice University2020

    … our model. Another example is the chemotaxis: Leukotriene B4 is secreted as exosomes by neutrophils, serving as a secondary gradient to amplify the chemical attraction of primary chemoattractants. We introduce a model to compare the enhancement effect between directly releasing Leukotriene B4 …

    rice Repository record

  5. Determination of Absolute Protein Content of Hepatic CYP4F Enzymes in Human Liver Microsomes Using LC/MS/MS Methodology and Comparison with Immunoquantification and Enzyme Activity

    Michaels, ScottUniversity of Kansas2013

    … of endogenous compounds (arachidonic acid, leukotriene B4), nutrients (vitamin K1 and vitamin E), and xenobiotics (parfuramidine (DB289), DB1230, fingolimod). The CYP3A subfamily of enzymes are known to metabolize a wide variety of physiologically and pharmaceutically important substances. …

    ku Repository record

  6. Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population

    손, 진경2011

    … of TNFα, which in turn induces the synthesis of leukotriene B4. The aim of this study is to elucidate the genetic contribution of the IL-18 gene on the phathogenesis of AIU. MATERIALS AND METHODS: To perform genetic association study of IL-18 gene polymorphism with AIU, 247 patients with …

    ajou Repository record

  7. Understanding how neutrophils self-organise their migration to sites of inflammation in vivo

    Poplimont, Hugo Clément GeoffreyUniversity of Cambridge2020

    … attractant production, notably of the lipid leukotriene B4 (LTB4). The decision to release attractants at the single-cell level is important and impacts the magnitude of the entire immune response. However, the precise mechanisms triggering this decision remain unclear. In this study, I …

    cambridge Repository record

  8. Neural and Behavioural Consequences of Chronic Inflammation following Spinal Cord Injury

    Allison, DavidBrock University2016

    … eicosanoids prostaglandin E2 (PGE2) and leukotriene B4 (LTB4). In addition to such molecular indices, actual changes in each of the outcome variables of interest were assessed. Levels of depression were assessed by questionnaire via the Center for Epidemiological Studies Depression Scale …

    brock Repository record

  9. Harnessing Systems Bioengineering Approaches to Study Microbe-Microbe and Host-Microbe Interactions in Health and Disease

    Datla, Udaya SreeVirginia Tech2024

    … (TNF-α) and interleukin-6 (IL-6), but not leukotriene B4 (LTB4), compared to the infection alone. Our device platform is unique in that the nanoliter well-assisted individual neutrophil trapping enables us to quantify NET release with single-cell precision. Besides, incorporating confined …

    vt Repository record

  10. Effect of atorvastatin on asthma control and airway inflammation: a randomised controlled trial

    Hothersall, Eleanor JaneUniversity of Glasgow2008

    … (IL-6), IL-5, IL-8, sICAM-1, TNF-α, leukotriene B4 (LTB4) and high sensitivity C-reactive protein (hsCRP), and blood lymphocyte proliferation. Results At 8 weeks, the change in mean morning PEF, as compared with baseline, did not differ between the atorvastatin and placebo treatment …

    glasgow Repository record

  11. Neutrophil Chemotaxis in Multiple Chemoattractant Gradients

    Kimura, YukiUniversity of Illinois at Urbana-Champaign2011

    Chemotaxis, the phenomenon in which cells move in response to extracellular chemical gradients, plays a prominent role in the mammalian immune response. During this process, a number of chemical signals, called chemoattractants, are produced at or proximal to sites of infection and diffuse into the …

    uiuc Repository record

  12. Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections

    Brown, LukeCumming School of Medicine2025

    … swarming and clustering, which preceded LTB4 dependent immunothrombosis. These immunothrombi trapped bacteria and promoted platelet dependent microbial resistance but also caused lethal vascular occlusions. Cathelicidin deficiency impaired this host defence mechanism leading to bacterial …

    calgary Repository record