Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Leukocyte rolling"”.
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Rapid 3-D laser microprinting of bioscaffolds and patterning of proteins
… patterns of P-selectin, a protein involved in leukocyte recruitment from blood vessels. We showed that leukocyte rolling occurred on P-selectin patterned collagen channels. Second, we presented a 3-D printed microvasculature by seeding endothelial cells into a printed collagen scaffold with …
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Isolation and engineering of a high affinity antibody against P-selectin glycoprotein ligand-1 (PSGL-1)
… attractive because this adhesion mediates leukocyte rolling which occurs early in the inflammatory cascade before extensive tissue damage caused by the amplification of inflammation by proinflammatory cytokines. Currently, no subnanomolar antagonists of selectin adhesion are available. The …
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SELECTIVE CB2 RECEPTOR ACTIVATION AMELIORATES INFLAMMATION IN CENTRAL NERVOUS SYSTEM BY REDUCING TH17 CELL DIFFERENTIATION AND IMMUNE CELL ACCUMULATION.
… previously that CB2 selective agonists inhibited leukocyte rolling and adhesion to CNS microvasculature and ameliorate clinical symptom in both chronic and remitting-relapsing EAE models; and our previous studies also demonstrated therapeutic potential of CB2 agonist improving recovery following …
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Development of a direct photochemical method for the generation of biomolecular interfaces for applications in leukocyte biology
… cell-substrate interactions and fundamental leukocyte biology studies. Substrates tailored to present P-selectin or E-selectin, which are proteins expressed on the inflamed endothelium, were applied to flow assays with neutrophils isolated from whole blood for investigating the effects of …
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CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9
… with our previous observation of decreased leukocyte rolling and adhesion to brain microvasculature. However, the reduction in MMP-2/9 expression suggests that CB2R agonists may also affect leukocyte transmigration into the perivascular space and further infiltration into the CNS parenchyma. …
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Biomolecularly and mechanically instructive materials for guiding cell-substrate interactions
… the mechanism by which bromelain affects cell rolling during the early steps of inflammation. The latter part of this work utilized BP-mediated immobilization on two substrates, collagen-glycosaminoglycan membranes and polyacrylamide hydrogels, to evaluate stem cell diffferentiation. In …