Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Leukemia Inhibitory Factor"”.
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Leukemia Inhibitory Factor (LIF): Murine Preimplantation Embryo Development, Implantation Rates, and Skeletal Development
<p>Leukemia inhibitory factor (LIF) is a pleiotropic cytokine which demonstrates perplexing physiological effects. It has been demonstrated that LIF is essential for implantation in mice. Little is known relating to the manner by which LIF effects pre-implantation and post-implantation development. …
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Tissue Engineering bei peripheren Nerven : dreidimensionale Fibrin/Schwann-Zellen-Matrix in Poly-Caprolacton-Konduiten zur geführten Defektüberbrückung
… Fibrin-Matrix und des neurotrophen Faktors LIF (Leukemia Inhibitory Factor). Hierzu wurden Schwann-Zellen aus dem N. ischiadicus neonataler Ratten kultiviert. Als Läsionsmodell diente ein 10mm langer Defekt im bukkalen Ast des N. facialis der Ratte, der überbrückt wurde mit PCL-Konduiten. Nach 4 …
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Effects of oxygen on embryonic stem proliferation, energetics, and differentiation into cardiomyocytes
… with the differentiation-suppressing cytokine leukemia inhibitory factor (LIF) in the culture medium, and low oxygen had, at most, a small differentiating-promoting effect during culture without LIF. Aerobic metabolism was used to generate approximately 60% of the energy required by …
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Cue, signal, response analysis of murine embryonic stem cell differentiation : multivariable analysis of cytokine and ECM effects on commitment to differentiation
… governing mouse ES cell differentiation. A factorial design was used to evaluate responses of ES cells to combinations of leukemia inhibitory factor (LIF) and fibroblast growth factor-4 (FGF4) as soluble signals along with fibronectin (Fn) and laminin (Ln) as adhesion substrates. Factorial …
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Fundamental differentiation and growth characterization of murine embryonic stem cells in varied culture conditions
… both in the presence and absence of leukemia inhibitory factor (LIF) which prevents spontaneous differentiation, as well as at varied LIF concentrations and seeding densities. In addition, fundamental growth kinetic and metabolic profiles were obtained to get a more complete picture …
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Control of cell fate decisions of embryonic stem cells by mechanical forces
… in the absence of soluble differentiation factors. Now that we see that mESCs can be directed to differentiation solely by external mechanical forces, we next examined if mESCs can be kept in their pluripotent state by culturing them on soft substrates. We found that soft substrates that …
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The Role of LIFR Signaling in Innate Immunity
… eradication.</p> <p>Here, we uncovered LIFR (leukemia inhibitory factor receptor) restrains low-grade chronic inflammation in the BM by restraining STAT1 signals. LIFR deletion in CD11c-expressing cells resulted in reduced frequency of BM long-term (LT) HSC, increased the frequency of …
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Modulation of bovine preimplantation embryonic development and pregnancy by FGF2, LIF, and IGF1
… improve the in vitro system. Fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF1) as a cytokine cocktail named FLI, was first recognized for its role in embryonic stem cell derivation and then for improvements to in vitro porcine embryo …
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Humna fetal neural stem cells: Proliferation and differentiation in response to growth factors and role in locomotor recovery after spinal cord contusion injury
… in seven regimens with basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) and leukemia inhibitory factor (LIF), either alone or in combinations. We found that a combination of bFGF, EGF and LIF expanded hNSCs more efficiently than any other treatment. Differentiation patterns …
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Supplementing Bovine Embryo Culture Media to Improve the Production and Quality of In Vitro Produced Bovine Embryos
… explored the role of interleukin-6 (IL6) and leukemia inhibitory factor (LIF) in preimplantation bovine embryos. Neither cytokine affected the total percentage of embryos which developed to the blastocyst stage in vitro. However, supplementation of IL6 increased blastocyst inner cell mass …
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Investigating the Actions of Interleukin-6 Family Members on Post-Hatching Blastocyst Development in Cattle
… we found that both human recombinant IL6 and leukemia inhibitory factor (LIF) increases ICM cell number before cryopreservation. Supplementing interleukin 11 (IL11) had an intermediate effect between the controls and the IL6 and LIF treatments. Supplementing IL6 also increased the ICM:TE …
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Die Rolle von CNTF und LIF bei glialen Reaktionen nach Läsion des Nervus opticus
Der „Ciliary Neurotrophic Factor” (CNTF) und der „Leukemia Inhibitory Factor“ (LIF) sind zur IL-6 Familie gehörende Zytokine, denen eine wichtige Rolle bei der Regulation von Gliazellen bei postläsionalen Prozessen zugeschrieben werden. Diese Annahme beruht im wesentlichen auf in vitro und in …
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Effects of transvaginal follicular aspiration on oocyte recovery, hormonal profiles before and after GnRH, and growth factor influence on embryo development
… was to determine if platelet-derived growth factor (PDGF-BB) and leukemia inhibitory factor (LIF) exhibit a stimulatory effect during in vitro co-culture with Buffalo Rat liver cells (BRL). Oocytes were matured in transit, fertilized in vitro, and embryos were co-cultured with BRL cells for 7 …
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Biophysical and gene expression change in living cells by force-induced mechanotransduction
… Increasing evidence suggests that mechanical factors play a critical role in fate decisions of stem cells. We demonstrate that forces transmitted through different natural extracellular matrix proteins or cell-cell adhesion molecules such as fibronectin, laminin or E-cadherin, have different …
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Neuronale und gliale Reaktionen nach Fimbria -Fornix-Durchtrennung : zur Rolle von CNTF und LIF
CNTF und LIF zeigen neuroprotektive Effekte auf axotomierte septohippocampale Projektionsneurone des medialen Septums (MS) nach Fimbria-Fornix-Durchtrennung. Neuere Untersuchungen lassen eine zelltyp-spezifische Wirkung der endogenen Cytokine auf GABAerge bzw. cholinerge MS-Neurone nach Axotomie …