Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 645 for “"Leukemia"”.
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IKAROS and LEUKEMIA
Acute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct …
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Immunotherapy and immunosuppression in myeloid leukemia
Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis aimed at contributing to the understanding of the role of natural killer (NK) …
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Pharmacological management of leukemia in children
Leukemia is a hematological malignancy or a cancer of the blood. It develops in the bone marrow. Leukemia is usually described either as "acute" or "chronic". In this thesis, looks into understanding the wide variety of treatment for leukemia in children. in summary, with addition of supportive …
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Mapping the murine leukemia virus genome.
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 1978
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Deciphering the Pathogenesis of Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a malignant disorder of the blood system. Hematopoietic stem cells (HSCs) supply and maintain this system by differentiating via intermediates into lineage-restricted progenitors that strongly proliferate to keep up with the high turn-over of mature blood cells. In …
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Frequency of leukemia types and flowcytometric immunophenotypic characterization of acute lymphoblastic leukemia presenting at the university teaching hospital, Lusaka
… tool that can be performed to diagnose Leukemias and in this study it was used to diagnose and sub type Acute Lymphoblastic Leukaemia (ALL).The aim of the study was to determine the frequency of the Leukaemia types and to characterize ALL at UTH by immunophenotypes and compare these …
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Frequency of leukemia types and flowcytometric immunophenotypic characterization of acute lymphoblastic leukemia presenting at the university teaching hospital, Lusaka
… tool that can be performed to diagnose Leukemias and in this study it was used to diagnose and sub type Acute Lymphoblastic Leukaemia (ALL).The aim of the study was to determine the frequency of the Leukaemia types and to characterize ALL at UTH by immunophenotypes and compare these …
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Role of Gsh Metabolism In Mediating Stromal-Leukemia Interaction and Promoting Cell Survival and Drug Resistance In Chronic Lymphocytic Leukemia
<p>Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western countries. The interaction between CLL cells and the bone marrow stromal environment is thought to play a major role in promoting the leukemia cell survival and drug resistance. My dissertation works proved a …
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Integrated Genomics Of Susceptiblity To Therapy-Related Leukemia
Therapy-related acute myeloid leukemia t-AML is a secondary, generally incurable, malignancy attributable to the chemotherapeutic treatment of an initial disease. Although there is a genetic component to susceptibility to therapy-related leukemias in mice, little is understood either about the …
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Treatment Response Prediction in Acute Myeloid Leukemia Patients
Predicting acute myeloid leukemia (AML) patient treatment response has the potential to impact clinical decisions. A prediction given at the time of diagnosis for treatment response can assist physicians in making effective treatment decisions and improving patient prognosis. This project aimed to …
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Array based genetic profiling of chronic lymphocytic leukemia
… defect has been described in chronic lymphocytic leukemia (CLL), recurrent genomic aberrations (i.e. deletions of chromosome 11q, 13q, 17p and trisomy 12) are important for prognostication. Deletion of 13q as single aberration is associated with the best prognosis, whereas del(11q) and del(17p) …
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Leukemia/Lymphoma Related Factor in Human Prostate Carcinoma
… role in pathogenesis of BPH and PC are unknown. Leukemia/lymphoma related factor (LRF)/ Pokemon (POK erythroid myeloid ontogenic factor) is a newly discovered transcription factor. It is a 72 kDa zinc-finger protein encoded by the ZBTB7A gene, which resides in the 19p13.3 locus. LRF/Pokemon …
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Somatic Mutation Detection in Leukemia-Derived Circulating DNA: Utility in Monitoring Clonal Dynamics and Disease Response in Pediatric Acute Lymphoblastic Leukemia
… strategies ofpediatric acute lymphoblastic leukemia (ALL), relapse still represents a major challenge. Pediatric ALL demonstrates branched evolution in response to selective pressure exerted by therapy; relapse founder clones emerge from pre-leukemic clones or minor subclones present at …
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Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia
… present in 25% of childhood acute lymphoblastic leukemia. This fusion gene is important for leukemia development but is not sufficient for leukemia to arise. Hence, the additional genetic changes present in leukemic ETV6/RUNX1-positive cells give important clues regarding the history of the …
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Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is caused by the transformation of a primitive hematopoietic cell by the BCR/ABL1 fusion gene that is formed through the chromosomal translocation t(9;22). CML is currently successfully treated with tyrosine kinase inhibitors targeting the ABL1 kinase domain. However, …
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Regulation of Myeloid Leukemia Cells by Platelet Factor 4
… be the main drivers of relapse in Acute Myeloid Leukemia. LSCs ability to retain key properties of healthy hematopoietic stem cells (HSCs) means they are quiescent, chemo-resistant, and able to repopulate eradicated leukemic blasts, making LSCs an important target in AML. However, their …
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Chromatin Architecture Aberrations Contribute and Acute Lymphoblastic Leukemia Relapse
… changes that underlie B-cell acute lymphoblastic leukemia relapse. I found recurrent loss of DNA methylation in patient-matched relapse samples that indicate a more stem-like chromatin state. Together, my work investigates the relationship between multiple components of the chromatin architecture, …
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