Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Leukaemia-inhibitory factor"”.
-
Polarised secretion of leukaemia inhibitory factor
Leukaemia inhibitory factor (LIF) is a cytokine that is active on a wide variety of cells. Multiple LIF transcripts have been described. The transcripts LIF-D and LIF-M encode different signal peptides, which in mouse have been associated with differential localisation of the mature protein. LIF-D …
-
Mutationen im Leukaemia-Inhibitory-Factor (LIF)-Gen bei wiederholtem Implantationsversagen nach extrakorporaler Befruchtung
… Rolle. Unter diesen Mediatoren ist auch Leukaemia Inhibitory Factor (LIF) am Implantationsvorgang beteiligt. Bei weiblichen Mäusen mit einer homozygoten Inaktivierung des LIF-Gens bleibt nach erfolgreicher Befruchtung ihrer Oozyten die Implantation aus, obwohl ihre Blastozysten …
-
Gentherapeutischer Ansatz bei der peripheren Nervenregeneration
… mit verschiedenen Reportergenen getestet.LIF(Leukaemia-inhibitory factor) RNA wurde aus dem Hirngewebe von neugeborenen Ratten gewonnen und in der RT-PCR vervielfältigt. Die DNA wurde in verschiedene Expressions- und Transfervektoren einkloniert (pCMX-PL 1, pBabe, pRSETA). Eine …
-
Human Organotypic Retinal Cultures as a model of human retinal ganglion cell degeneration in glaucoma. Effects of epigenetic regulation and mesenchymal stem cell derived growth factors.
… effect of mesenchymal stem cell derived growth factors on the RGC survival was studied and the role of epigenetic regulation of retinal cell gene expression was examined. Methods: Quantitative real-time polymerase chain reaction (QRT-PCR) was used for assessment of retinal cell marker genes …
-
Determining the Signalling Pathways that Govern Human Naive Pluripotency
… MEK, GSK3 and PKC inhibition in conjunction with leukaemia inhibitory factor (LIF) supplementation (t2iLGö) and a feeder layer of inactivated mouse embryonic fibroblasts. However, the way in which this signalling environment is interpreted in order to maintain naïve pluripotency remains unclear. I …
-
An in vitro model of human yolk sac and epiblast crosstalk
… JAK/STAT signalling via ACTIVIN-A, CHIRON, and leukaemia inhibitory factor (LIF) (ACL) induced an endodermal fate in human pluripotent stem cells (hPSCs). Functional and transcriptional analysis of ACL-treated cell populations revealed that the pluripotent state harboured by hPSCs determines the …
-
Molecular mechanisms regulating implantation
… ESR1 controls stromal cell decidualization via Leukaemia Inhibitory Factor (LIF) and Indian Hedgehog (IHH). The second part of this study investigates the role of signal transducer and activator of transcription 3 (STAT3) in the uterine epithelial cells during implantation. STAT3 is activated …
-
Cytokines and human endometrial function: Abnormalities in recurrent miscarriage women.
… events through local autocrine and paracrine factors, such as cytokines. The role of cytokines in the human endometrium still remains to be determined, but they are thought to play an important role in the implantation process. This study has therefore focused on the expression of …
-
STAT-3-Aktivierung in humanen endometrialen Primärzellkulturen durch LIF und IL-11
Leukemia inhibitory factor (LIF) and Interleukin (IL) 11, two cytokines of the IL-6 Family, have been identified as regulatory molecules during blastocyst implantation in mice. IL-11 knock out (k.o.) mice, as well as LIF Rß k.o. mice demonstrated fertility problems. Thus the hypothesis was …
-
Tissue Engineering bei peripheren Nerven : dreidimensionale Fibrin/Schwann-Zellen-Matrix in Poly-Caprolacton-Konduiten zur geführten Defektüberbrückung
… und des neurotrophen Faktors LIF (Leukemia Inhibitory Factor). Hierzu wurden Schwann-Zellen aus dem N. ischiadicus neonataler Ratten kultiviert. Als Läsionsmodell diente ein 10mm langer Defekt im bukkalen Ast des N. facialis der Ratte, der überbrückt wurde mit PCL-Konduiten. Nach 4 Wochen …
-
Herstellung und Charakterisierung hochaffiner Inhibitoren für die Zytokine IL-6 und LIF basierend auf den Liganden-bindenden Domänen ihrer Rezeptor-Untereinheiten
Cytokines are small secreted proteins produced by different cell types in nearly all tissues. They are used as intercellular mediators being involved in the regulation of immunity and inflammation. Dysregulated cytokine production plays an important role in the development and progression of …