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Showing 1 to 11 of 11 for “"Leucine-rich repeat kinase 2"”.

  1. α-Synuclein and Leucine Rich Repeat Kinase 2 (LRRK2) Interaction During Axonal Transport

    Chakraborty, Piyali; 0000-0003-0862-3280State University of New York at Buffalo2025

    M.S.

    buffalo Repository record

  2. Exploring the role of Leucine Rich Repeat Kinase 2 within the innate immune system

    Levy, Daniel Robert SiegfriedUniversity of Cambridge2018

    Leucine rich repeat kinase 2 (LRRK2) is a 286 kDa protein expressed in a variety of tissues and cell types, including neuronal tissue and innate immune cells. Mutations in LRRK2 have been linked to inflammatory diseases, most notably Crohn’s disease and Parkinson’s disease. Further to this, LRRK2 …

    cambridge Repository record

  3. LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE

    DULE, NEVIAUniversità degli Studi di Milano2024

    Leucine-Rich Repeat Kinase 2 (LRRK2) is a large protein encompassing multiple functional domains, including kinase and GTPase enzymatic activity and several protein-protein interaction modules. It is expressed in the central nervous system (CNS) and it is among the most important genetic risk …

    milano Repository record

  4. A clinical and molecular genetic study into familial and sporadic Parkinson’s Disease

    Lewthwaite, Alistair JohnUniversity of Birmingham2009

    … role of a recently identified hereditary PD gene leucine rich repeat kinase 2 (LRRK2) in PD in the United Kingdom (UK). In this thesis I have confirmed the importance of pathogenic LRRK2 mutations in UK familial PD (fPD). In addition I identified three novel frameshift mutations. I investigated …

    birmingham Repository record

  5. A NOVEL RIT2-LRRK2 AXIS MODULATES LYSOSOME FUNCTION: INSIGHT FOR PARKINSON'S DISEASE PATHOPHYSIOLOGY

    PIZZI, SARAUniversità degli Studi di Milano2023

    … di Parkinson (PD). L’attività chinasica di Leucine-rich repeat kinase 2 (LRRK2) modula autofagia e funzionalità lisosomiale, e la sua inibizione farmacologica è protettiva per neurodegenerazione e patologia di α-sinucleina (αSyn). Tuttavia, rimane da chiarire la via di segnalazione che …

    milano Repository record

  6. α-Synuclein phosphorylation and related kinases in Parkinson’s disease

    Zhou, Jin-XiaUNSW, Sydney2013

    … phosphorylated at serine 129 (S129P). Several kinases have been suggested to facilitate α-synuclein phosphorylation in PD, but without significant human data the changes that precipitate such pathology remain conjecture. The major aims of this project were to assess the dynamic changes of …

    unsw Repository record

  7. The effects of the Parkinson’s disease-associated proteins LRRK2 and TMEM175 on the lysosomal profile of cultured mammalian cells under lysosomal stress conditions

    Himanka, EllaHelsingin yliopisto2025

    … to be involved in autophagy-lysosome pathways. Leucine-rich repeat kinase 2 (LRRK2) has been found as the most common genetic risk factor for PD. LRRK2 is involved in various cellular processes, including cell signalling, vesicle trafficking, and the maintenance of lysosomal homeostasis. Another …

    helsinki Repository record

  8. Mutazione LRRK2-G2019S all'interfaccia dell'interazione astrocita- neurone durante lo sviluppo post natale e l'invecchiamento

    GIACHINO, CARMELAUniversità degli studi di Catania2022

    Mutazioni del gene Leucine rich repeat kinase 2 (LRRK2) rappresentano le più comuni mutazioni nelle forme ereditarie di morbo di Parkinson (MP), una tra le più comuni malattie neurodegenerative, caratterizzata dalla morte progressiva dei neuroni dopaminergici mesencefalici (mDAn) della substantia …

    catania Repository record

  9. Investigating the Non-globular Proteins of the Canonical Wnt Signalling Pathway

    Smith, Benjamin MartinUniversity of Cambridge2018

    … of adult tissues. The twelve Armadillo (ARM) repeat-containing protein beta-catenin acts as the signal transducer in this pathway and is continuously degraded in the cytosol by the beta-catenin destruction complex (BDC). Upon receiving the Wnt signal the BDC is inactivated, allowing …

    cambridge Repository record

  10. Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn’s Disease

    Phillips, Anne MaireadThe University of Edinburgh2011

    … locus in a recent GWAS, tagging SNPs across the leucine rich repeat kinase-2 (LRRK2) gene, near the MUC19 gene, were also genotyped and examined in the Dundee cohort for an association with IBD, CD and UC susceptibility, but was also negative when corrected for multiple testing. The studies …

    edinburgh Repository record

  11. Characterization of Parkinson's Disease-associated LRRK2 Kinase

    Katsemonova, KristinaUniversity of Dundee2016

    … neurons in the substantia nigra. Mutations in leucine-rich repeat kinase 2 (LRRK2) have been linked to autosomal familial and sporadic PD. It is now estimated that approximately 1% of Parkinson’s disease (PD) results from mutations in LRRK2. Previous studies have established that the most …

    dundee Repository record