Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Let-7a"”.
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Platelet micro-particles induce angiogenesis through the delivery of the micro-RNA Let-7a into endothelial cells
… characterised by increased platelet activation and increased secretion of platelet micro-particles that induce angiogenesis. This study determined the role of platelet micro-particles derived microRNA in the regulation of angiogenesis and migration, with a focus on the regulation …
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MicroRNA-mediated Attenuation of Inflammation in NZB/W Lupus Mice
… SLE, contains a potential binding site for miR-let-7a. In order to examine if alterations in miR-let-7a expression can influence inflammatory mediator production in SLE, we isolated mesangial cell miRNAs from 8 and 32- week-old female New Zealand Black/White (NZB/W) mice. We found miR-let-7a …
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Role of Selected Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Myelodysplastic Syndrome // Роля на подбрани плазмени микроРНК-и като диагностични и прогностични маркери при миелодиспластичен синдром
… (miR-22, miR-144, miR-16, miR-451a, and let-7a) as potential diagnostic and prognostic biomarkers in myelodysplastic syndrome (MDS). The study aims to investigate the expression of these five microRNAs in the plasma of patients with MDS and healthy controls, and to analyse their …
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A novel route to oncogenic activation of cell cycle kinase Aurora A
… required for the onset of mitosis and the completion of cell division. Recent research has uncovered roles of AURKA that are independent of the kinase activity and that regulate multiple cellular processes, including motility, senescence, and transcription. Therefore, control of cellular …
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E2F1 and Tumor Suppression: The Role of P21, Mirnas, and The Dna Damage Response
… regulated in mouse epidermis, including let-7a, let-7c, and miR-301. Additionally, regulation of miR-301 involves binding of E2F1 to its promoter. Finally, our data indicate a role for E2F1 at sites of DNA damage requiring E2F1’s phosphorylation at serine 31 which may involve DNA repair. …
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Exploring MicroRNA as a Biomarker for Multiple Sclerosis (EMBleMS): A Pilot Study
… that the mean relative expression levels of let-7a (p = .038), miR-27b (p = .007), and miR-125b (p = .032) were higher in those with less disability than in individuals with greater disability, supporting the second hypothesis. This study adds to the body of knowledge concerning microRNAs …
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To evaluate the role of miRNAs as potential diagnostic and prognostic biomarkers for Asbestos-related interstitial lung diseases (ILD), Non-Small Cell Lung Cancer (NSCLC) and Malignant Pleural Mesothelioma (MPM)
… unexposed subjects. miR-6516-5p, miR-942-5p, and let-7f-5p showed a 92% diagnostic accuracy (95% CI: 0.76-1.00) in differentiating asbestos-related ILD-cases from ILD-free subjects formerly exposed to asbestos. miR-4714-3p and miR-20a-5p showed a 91% diagnostic accuracy (95% CI: 0.78-1.00) in …