Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Leptin receptor"”.
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Investigation of hypothalamic molecular mechanisms underlying narcolepsy and obesity through DNMT1 and leptin receptor signalling
… methods to identify proteins that regulate human leptin receptor (LEPR) signalling, since leptin signalling is essential for normal body weight regulation. Several candidate proteins were identified that may negatively regulate signalling through LEPR and are of potential therapeutic relevance for …
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Genomic and Physiological Differences for Ghrelin and Leptin Receptor in Lines of Chickens Selected for High and Low Body Weight
… have low sympathetic nervous system activity. Leptin, leptin receptor, and ghrelin genes influence the ANS regulation of body weight and food intake. The aim of this study was to investigate whether there are differences in leptin, the leptin receptor, or ghrelin regulation between lines of …
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The Role Of Protein Tyrosine Phosphatase 1b In The Central Regulation Of Energy Homeostasis
… of energy homeostasis via negative regulation of leptin signaling. Mice with central nervous system (CNS)-specific PTP1B deficiency demonstrate clear metabolic improvements, including decreased body weight and adiposity presumably due to enhanced leptin sensitivity. Interestingly, compound …
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Novel Interactions of the Hormone Leptin Revealed by PET Imaging in Rodents and Rhesus Macaques
<p>Leptin is a polypeptide hormone, secreted principally by adipose tissue, which functions as an afferent signal in a feedback loop to maintain body weight and energy homeostasis. In addition to its well documented effects on food intake and energy expenditure, leptin modulates the function of …
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Metabolic Mechanisms of Nutritionally Regulated Hormone Signaling on T Helper Cell Function
… the case of overnutrition or obesity, levels of leptin, insulin, and insulin like growth factor 1 (IGF-1) are increased, whereas they are decreased in the setting of undernutrition. Either undernutrition or overnutrition results in a dysregulated immune response that contributes to increased …
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On the role of SOCS proteins in leptin signalling
Leptin is a pleiotropic cytokine that was initially identified as a key player in food intake and energy expenditure. It is produced mainly in adipose tissue and circulating leptin levels correlate well with the amount of body fat. As an adipostat, leptin passes the blood brain barrier to inform …
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The Effect of Steroid Hormones on Expression of the Leptin Receptors
Leptin, a peptide hormone secreted by adipocytes, has been widely studied in the attempt to understand its contributions and relation to obesity. There is a sexual dimorphism in leptin levels between men and women, suggesting a possible influence of steroid hormones on leptin expression and …
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Factors Regulating the Intrarenal Renin-Angiotensin System and Renal Damage During Aging
… with the angiotensin (Ang) II type 1 (AT1) receptor antagonist L-158,809 in the F344 rats prevented the age-related increase in serum leptin, insulin, glucose, body weight and increased excretion of Ang peptides and protein that occur independently of blood pressure or plasma RAS peptides. …
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
Leptin and adiponectin are the adipokines that are shown to exert pro-hypertrophic and anti-hypertrophic effects respectively, in cardiomyocytes. We sought to determine the direct interaction between the adipocytes and cardiomyocytes during endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and …
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The effects of leptin on placental development and function, and offspring behavior in mice
… is communicated throughout the body by means of leptin. This hormone also plays a role in implantation and placental development and function, as well as programming behavior via alteration of brain function. The current research provides insight into how leptin is involved in placental and fetal …
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Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment
… crosstalk creates conditions ripe for hijacking leptin receptor (LEPR)-signaling, which in turn launches downstream PI3K-AKT-mTOR signaling at the benign-malignant transition. By functionally interrogating each step in this pathway, we unravel how dynamic temporal crosstalk with the …
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The Examination of Leptin Receptors, Matrix Metalloproteinases-2 and -9 and Tissue Inhibitors of Metalloproteinases in the Rat Cervix
… of interest in the physiology of reproduction is leptin. Leptin was recently shown to enhance cervical collagenolysis and elasticity. As a result, the objective of this thesis was to determine if leptin receptors are present in the cervix and whether leptin has a role in regulating two …
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The effects of obesity and surgically-induced weight loss on exercise ventilation: influence of central adiposity and serum leptin
… adults by altering normal ventilatory mechanics. Leptin, an inflammatory adipocytokine, is elevated in obesity and has been shown to alter ventilatory responses to exercise. Leptin’s bioavailability appears to be regulated by its soluble receptor (LRe), which is reduced in obesity. Roux-en-Y …
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EFFECTS OF LEPTIN ON ESTABLISHED GLIOBLASTOMA CELL LINES
… β<sub>3</sub> adrenergic stimulation to decrease leptin gene expression as a possible novel therapeutic. The role of leptin and β<sub>3 </sub>adrenergic stimulation were examined using a cell viability assay to assess changes in proliferation and quantitative PCR to assess gene expression. With …
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Leptin Action on Dopamine Neurons: Biochemical and Behavioral Analysis
… affect drug seeking behavior. The discovery that leptin receptor (Lepr) is expressed on dopamine neurons in the ventral tegmental area (VTA) provides a link between metabolic state and rewarding behavior. By using a multitude of techniques, the functional roles for Lepr signaling on dopamine …
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Loss of Ventromedial Hypothalamic Leptin Receptors Results in Increased Adiposity and a Metabolic Syndrome
… including mild steatosis, dyslipidemia, and hyperleptinemia. From a young age, Lepr KOleptin, an adipocyte-derived hormone, acts on the brain to suppress appetite and stimulate energy expenditure greatly extended our understanding of such mechanisms. The leptin receptor is expressed in a number of …
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Identifying Diagnostic Biomarkers: Gene Expression Profiling Leptin in Dental Pulp Tissue
Recent studies emphasized the role of leptin/leptin receptor (LEP/LEPR) in normal and inflammatory conditions of dental pulp tissues. LEP/LEPR activity is linked to potential immunomodulation responses during bacterial-induced inflammatory conditions. Additionally, there is substantial association …
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Restriction of Food Intake by Dorsomedial Hypothalamus
<p>Leptin deficient ob/ob mice eat voraciously and their food intake is markedly reduced by leptin treatment. Leptin acts in part by regulating the activity of AGRP neurons and POMC neurons in the arcuate nucleus and neurons in other brain regions. In these dissertation, I will describe how we …
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Cardiac mitochondrial respiration in two rodent models of obesity
… of diet-induced obesity and b) a transgenic (leptin receptor deficient) mouse model of obesity-induced type II diabetes. For the diabetic mouse model, we determined cardiac mitochondrial respiratory function in an age-dependent (10-12, 18-20 and 55-56 weeks) and gender-dependent (male versus …
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