Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 235 for “"Leptin"”.
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Leptin verbessert weibliche Fertilitätsmarker bei Lipodystrophie
… mit Lipodystrophie haben signifikant niedrigere Leptinspiegel. Leptin ist ein bekannter Mediator und Modulator der Hypothalamus-Hypophysen-Gonaden-Achse und beeinflusst somit die Reproduktionsfähigkeit. Inwiefern die Gabe von Leptin die Fertilität bei Lipodystrophie beeinflusst, ist bis jetzt …
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Effects of Leptin on the Rat Cervix
The investigations conducted indicate that leptin, in the presence of relaxin and estrogen, increases cervical extensibility, wet weight and dry weight. Leptin also is capable of increasing cellular proliferation and collagen accumulation in the cervix. However, the studies conducted indicate that …
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EFFECTS OF LEPTIN ON ESTABLISHED GLIOBLASTOMA CELL LINES
… β<sub>3</sub> adrenergic stimulation to decrease leptin gene expression as a possible novel therapeutic. The role of leptin and β<sub>3 </sub>adrenergic stimulation were examined using a cell viability assay to assess changes in proliferation and quantitative PCR to assess gene expression. With …
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Leptin Action on Dopamine Neurons: Biochemical and Behavioral Analysis
… affect drug seeking behavior. The discovery that leptin receptor (Lepr) is expressed on dopamine neurons in the ventral tegmental area (VTA) provides a link between metabolic state and rewarding behavior. By using a multitude of techniques, the functional roles for Lepr signaling on dopamine …
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On the role of SOCS proteins in leptin signalling
Leptin is a pleiotropic cytokine that was initially identified as a key player in food intake and energy expenditure. It is produced mainly in adipose tissue and circulating leptin levels correlate well with the amount of body fat. As an adipostat, leptin passes the blood brain barrier to inform …
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Leptin and the Control of Body Weight and Metabolism: Role for Stearoyl CoA Desaturase-1 and Other Leptin-Regulated Genes in the Liver
<p>Leptin is an adipocyte-derived hormone that regulates energy balance, metabolism, and the neuroendocrine response to altered nutrition. Mice lacking leptin (ob/ob) or its receptor (db/db) are massively obese and hyperphagic. They also have increased triglyceride deposits in multiple peripheral …
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Qualitative and Quantitative Regulation of the Leptin Gene in vivo
… energy store and by secreting adipokines such as leptin and adiponectin. Leptin functions as the afferent signal to the central nervous system in a negative feedback loop that maintains homeostatic control of adipose tissue mass. Leptin gene expression is highly correlated with cellular lipid …
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Age-dependent regulation of hippocampal excitatory synaptic transmission by leptin
… to suggest that the adipocyte-derived hormone, leptin is a diverse regulator of hippocampal synaptic function (Irving and Harvey, 2014). Previous studies demonstrate that leptin can regulate hippocampal excitatory synaptic transmission in an age-dependent manner at Schaffer collateral (SC)-CA1 …
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The Effect of Steroid Hormones on Expression of the Leptin Receptors
Leptin, a peptide hormone secreted by adipocytes, has been widely studied in the attempt to understand its contributions and relation to obesity. There is a sexual dimorphism in leptin levels between men and women, suggesting a possible influence of steroid hormones on leptin expression and …
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Identifying Diagnostic Biomarkers: Gene Expression Profiling Leptin in Dental Pulp Tissue
Recent studies emphasized the role of leptin/leptin receptor (LEP/LEPR) in normal and inflammatory conditions of dental pulp tissues. LEP/LEPR activity is linked to potential immunomodulation responses during bacterial-induced inflammatory conditions. Additionally, there is substantial association …
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Changes in gastrointestinal hormones, leptin, and satiety after gastric bypass surgery
… GI hormone ghrelin and the adipocytokine leptin decrease. These changes generally occur before substantial weight loss, suggesting that a component of the surgery is responsible. Subjective satiety has also been reported to increase after RYGB, likely because of changes in the GI hormones …
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The Effects of Intracerebroventricular Leptin on Milk Availability in Lactating Rats
… energy balance along with adipocyte derived leptin action to improved fertility. Recent evidence indicates that leptin hormone is present in breast milk and leptin receptors are well expressed in mammary epithelial cells. The hypothesis that insufficiency of leptin restraint in the …
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Characterisation of leptin mimetic agents as therapeutic targets in Alzheimer's disease
… and neuronal cell death. The endocrine hormone leptin, regulates food intake and body weight. However, leptin also has an important role in modulating excitatory synaptic transmission and synaptic plasticity at hippocampal synapses. Furthermore, recent studies have shown that leptin function is …
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Significance of leptin and ghrelin in systemic lupus erythematosus in Koreans
BACKGROUND: There have been evidence that leptin and ghrelin play an important role in metabolism, inflammation and autoimmunity. Elevated serum leptin levels have been described in patients with systemic lupus erythematosus (SLE), however there were no information about serum leptin and ghrelin …
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The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation
<p>Leptin, secreted by the adipose tissue, is an afferent signal of a negative feedback loop that regulates body weight balance through its effects on feeding and energy expenditure. Mutations in the leptin gene or its cognate receptor result in severe obesity in both human and mice. My thesis work …
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Novel Mechanisms Underlying the Inflammatory Effects of Leptin and Low Dose Endotoxin
… the causes of inflammatory complications include leptin and low dose endotoxin lipopolysaccharide (LPS). However, the mechanism underlying the involvement of these two mediators is not clearly understood. The purpose of this study is to understand the mechanism underlying inflammatory …
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Adipose tissue transplantation improves metabolic, behavioural and histological parameters in leptin-deficient mice
Leptin is an important adipokine involved in the regulation of food intake and energy homeostasis. In the absence of leptin or its functional receptors, rodents and humans develop a variety of metabolic dysfunctions, including decreased energy expenditure, severe insulin resistance, diabetes, …
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Adipose tissue transplantation improves metabolic, behavioural and histological parameters in leptin-deficient mice
Leptin is an important adipokine involved in the regulation of food intake and energy homeostasis. In the absence of leptin or its functional receptors, rodents and humans develop a variety of metabolic dysfunctions, including decreased energy expenditure, severe insulin resistance, diabetes, …
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