Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Lens epithelium-derived growth factor"”.
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The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
… signaling is a contributing biological factor to worse PCa prognosis, and is emerging as a key driver of PCa progression in the absence of androgens. The mechanism involves glucocorticoids binding to glucocorticoid receptor (GR) and bypassing the androgen receptor (AR) signaling pathway …
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Exploiting Lentiviral Integrations to Profile Chromatin
… dependency of the lentiviral integrase on LEDGF (Lens Epithelium-Derived Growth Factor). By fusing LEDGF to a chromatin-binding protein of interest, lentiviral integrations are redirected to the genomic targets of that protein, and can be identified through integration site mapping and …
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rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration
… photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor …
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Targeting LEDGF/p75 to Sensitize Chemoresistant Prostate Cancer Cells to Taxanes
… and the development of chemoresistance. Lens epithelium-derived growth factor p75 (LEDGF/p75) is a stressresponse protein that promotes cellular survival against environmental stressors, including oxidative stress, radiation, and cytotoxic drugs. It is overexpressed in PCa and other …
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Contribution of LEDGF/p75 to Prostate Cancer Chemoresistance
… response protein and transcription co-activator lens epithelium derived growth factor p75 (LEDGF/p75) in HRPC resistance to DTX. Our studies show that LEDGF/p75 overexpression attenuates DTX-induced lysosomal destabilization and cell death in a cellular model of HRPC, implicating this stress …
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Characterizing interactions between the cellular HIV-1 integration cofactor, LEDGF/p75 with chromatin and HIV-1 integrase
… between IN and viral cDNA, IN and cellular lens epithelium-derived growth factor/p75 (LEDGF/p75), as well as cellular LEDGF/p75 and chromatin. All three interactions could present novel drug targets and were the focus of my studies throughout my dissertation research. By understanding these …