Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Lenalidomide"”.
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Cost utility and budget impact analysis of bortezomib and lenalidomide for the treatment of relapsed/refractory multiple myeloma in the South African public health sector
… due to their proven high clinical efficacy are lenalidomide plus low-dose dexamethasone (LEN/DEX) and bortezomib monotherapy (BORT). The clinical effectiveness of both regimens for second-line treatment of RRMM was reported in the MM009/010 and the APEX studies, respectively, where each regimen …
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Correlazioni molecolari fra angiogenesi e neurodegenerazione
… potenziali effetti del farmaco immunomodulante lenalidomide nelle patologie neurodegenerative
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AI Assisted Cellular and 3D Spheroid Analyses for Combined Therapies Against Glioblastoma
… using U87 and T98G cell lines, radiation with lenalidomide (RT+Len, immunotherapy) in 3D spheroids, and temozolomide with graphene quantum dots (TMZ+GQD). Microscopy images at 24 and 48 hours were analyzed using k-means and hierarchical clustering with no labels or predetermined features. For …
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The Biology of Mantle Cell Lymphoma: Exploring the Gender Difference in Mantle Cell Lymphoma
… (female hormone in postmenopausal women), lenalidomide and IL-2 to further investigate the effects of these on the immune cells from male and female MCL patients. Incubation with IL-2 resulted in a significant increase in the cytotoxicity activity of male MCL patients but not female MCL …
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STRATEGIES TO TARGET HUMAN D-ASPARTATE OXIDASE AND MODULATE ENDOGENOUS D-ASPARTATE LEVELS IN SCHIZOPHRENIA
… were synthetised linking olanzapine to either lenalidomide or (VH032)-Me designed to recruit Cereblon or Von Hippel–Lindau (VHL) E3 ligases, respectively. These compounds were tested both in vitro and in cell lines for the interaction with DASPO and E3 ligases, and for the formation of ternary …
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Targeting Protein Degradation to Uncover Novel Oncoprotein Drivers of Acute Leukemia
… identified several active MGs with EC50 <5 µM. A lenalidomide competition assay and MHH-CALL-4 CRBN knock-down cells confirmed the CRBN dependency of these MGs. Among these compounds, SJ6986, a thalidomide-driven sulfonamide showed potent cytotoxicity in over 10 ALL cell lines tested in vitro. …
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Investigation of the anticancer activity and mechanisms of zinc diethyldithiocarbamate in multiple myeloma
… enhances the cytotoxicity of IMiDs (lenalidomide, Pomalidomide) and PI (bortezomib) and reverses resistance of MM cells to these drugs. ZnDDC is able to induce apoptosis in MM cells, demonstrated by cleavage of PARP-1. Although ZnDDC has no effect on the mRNA expression of cereblon …
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Analysis of Out-of-Pocket Expenditures of Oral Oncologics for Tennessee Recipients of Medicare Part D
… For the drugs in the study, imatinib, lenalidomide, sorafenib, erlotinib, dasatinib, sunitinib, vorinostat, nilotinib, and lapatinib, the annual out-of-pocket costs for each drug varied from $0 to a maximum of $1,133, based on plan design. Bivariate regression analysis showed that …