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Showing 1 to 20 of 40 for “"Leishmania major"”.
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Intracellular trafficking of Leishmania major peptidases
Leishmania resides inside mammalian macrophages, from where it is thought to manipulate the host immune system by releasing virulence factors. The cysteine peptidase CPB has been shown to be secreted by the parasite and act as such a virulence factor. CPB is released through the flagellar pocket …
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Regulators of autophagy in Leishmania major
… for life cycle progression and virulence of Leishmania. ATG8 is a ubiquitin like protein that is required for the formation of autophagosomes, and Leishmania uniquely possesses a set of ATG8-like proteins in addition to ATG8, that are distributed in three multi-gene families called ATG8A, …
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Lipoic acid metabolism in Leishmania major
Protozoan parasites of the genus Leishmania are the causative agents of a complex of diseases referred to as leishmaniasis. Leishmania have a digenetic life cycle that involves a sand fly vector (promastigote stage) and a mammalian host (amastigote stage). The parasites reside within very different …
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Studies on oligopeptidase B of Leishmania major
Peptidases of Leishmania are acknowledged virulence factors. It is hypothesised that peptidases are crucial for the survival of Leishmania in its hosts and that many could be potential targets for new antileishmanial drugs. As such, the investigation of peptidase activity in live Leishmania …
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Cloning and characterization of a single-stranded DNA-binding protein of Leishmania major
Protozoan parasites of the genus Leishmania are the etiologic agents of a spectrum of important human diseases collectively referred to as leishmaniasis. The major surface protein on all species of Leishmania is a highly abundant 63 kDa glycoprotein referred to as GP63. GP63 has been characterized …
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Studies on cathepsin B of Eimeria tenella and pyroglutamyl peptidase of Leishmania major
… PPI was identified in the genome database of L. major. Active recombinant enzyme was successfully produced in E. coli and its biochemical properties coincided with those of mammalian PPIs. The active site catalytic triad E101, C210, and H234 (L. major PPI numbering) was confirmed by mutagenesis. …
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Functional diversity and bilobe targeting by the MORN Domain Proteins of Leishmania major
Leishmania is a protozoan parasite responsible for a spectrum of diseases known as leishmaniasis. The cell body of Leishmania consists of single copies of several organelles whose faithful duplication are crucial for survival. Previously, a novel cytoskeletal organelle called the bilobe was …
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Defining D-Arabinose Metabolism in <i>Leishmania major</i> and <i>Crithidia fasciculata</i>
… structures of certain trypanosomatid parasites: Leishmania major lipophosphoglycan (LPG) Crithidia fasciculata lipoarabinogalactan (LAG) and Endotrypanum schaudinni glycoinositol phospholipids (GIPLs). The activated donor molecule of D-Arap has been identified in L. major as GDP-α-D-Arap. …
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Repurposing quinoline-based (metallo) drug leads for the treatment of Leishmania major-induced cutaneous leishmaniasis
Leishmaniasis is a vector-borne neglected tropical disease, of which cutaneous leishmaniasis is the most common form. There is a crucial need to develop new drugs for cutaneous leishmaniasis, as current drugs are sub-optimal due to parasite-specific drug resistance, drug-induced host toxicity and …
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Investigating the role of B and T lymphocytes in the course of murine Leishmania Major infection
… role of B-effector cells in the course of murine Leishmania Major (L. major). The second is a bioinformatic analysis of microarray slides of activated CD4 T-cells from L. major infected BALB/c and C57BL/6 mice in order to investigate the genetic determinants of their divergent disease phenotypes. …
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Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection
… to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses and the production of interleukin (IL)-4 and IL-13, which share a common receptor subunit, the IL-4 receptor alpha chain (IL-4α ). While IL-4 is the main inducer of …
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Investigating the role of IL-4/IL-13 signalling through the IL-4 receptor alpha (IL-4Rα) on keratinocytes in murine models of Leishmania major and Schistosoma mansoni
Keratinocytes represent the major cell type in the skin. During cutaneous leishmaniasis (CL) and schistosomiasis, the skin is important during the parasite life cycle. While Th1 immunity is required to control CL, protection during schistosomiasis requires Th2 immunity. Paradoxically, Th2 …
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Characterisation of novel T cell specific IL-4 receptor-alpha knockout mice : investigating the role of T cell responses to IL-4 in Leishmania major and Nippostrongylus brasilliensis infections
Includes bibliographical references (leaves 76-86).
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The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics.
Leishmania major is a protozoan parasite and infection in the human host causes severe cutaneous Leishmaniasis. The study aims to determine how signaling via the IL-4Rα on CD4+T cells causes susceptibility to L. major. We compared gene expression patterns early during infection in CD4+ T cells in …
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Factors affecting the protective effect provided by sand fly saliva immunization on the outcome of Leishmania infection
ENGLISH VERSION Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania, transmitted by its vector - female sand flies during the process of blood feeding. Preexposure to sand fly saliva prior to Leishmania infection affects the host immune system, leading to possible …
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Design and synthesis of novel P. fulciparum GDH inhibitors for use as potential antimalarial agents
… Trypanosoma brucei, Trypanosoma cruzi and Leishmania major.
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Structural and mechanistic studies on eukaryotic UDP-galactopyranose mutases
… tuberculosis, Aspergillus fumigatus, Leishmania major, and Trypanosoma cruzi. Galf has been implicated in pathogenesis in these organisms; thus the biosynthetic pathway of Galf is a target for drug design. Galf is synthesized by the enzyme UDP-galactopyranose mutase (UGM), which …
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NMR, Crystallographic and Quantum Chemical Studies of Metalloproteins and Bisphosphonate Inhibitors
… studies of the bisphosphonate inhibition of Leishmania major FPPS. The FPPS from Trypanosoma brucei (the causative agent of African sleeping sickness) is expressed in E. coli and purified for crystallographic studies. Single crystals of both drug-free and drug-bound FPPSs are obtained and …
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