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Showing 1 to 8 of 8 for “"Leishmania amazonensis"”.
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Immunopathogenic mechanisms of non-healing cutaneous leishmaniasis caused by Leishmania amazonensis infection
… project is to understand mechanisms employed by Leishmania amazonensis to evade host immune components, particularly B cells and interferon-gamma. Our data have shown that L. amazonensis infection induces B cell activation, leading to enhanced lesion development. In the absence of B cells, L. …
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Understanding the importance of vaccine formulation in generating protective immune responses against Leishmania amazonensis challenge
Leishmaniasis presents with a broad range of clinical manifestations and is caused by infection with Leishmania parasites. The life-long immunity found in individuals who naturally healed their infections suggests that development of a vaccine in feasible, although there is not one yet approved for …
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Parasite interactions with dendritic cells and macrophages: Implications for cutaneous Leishmaniasis caused by Leishmania amazonensis
Protozoan Leishmania is an important human pathogen that affects millions people worldwide. Investigation of experimental Leishmania infection in mice has been instrumental to our understanding of interactions between the parasite and the host immune system. Previous studies have established the …
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Caracterização da resposta imunometabólica frente a infecção por Leishmania amazonensis e Leishmania braziliensis em macrófagos de camundongos BALB/C
INTRODUCTION: Leishmaniasis is a neglected tropical disease caused by protozoa of the genus Leishmania and represents a serious public health problem. These parasites infect cells of the innate immune system, particularly macrophages, and possess the ability to modulate cellular metabolism during …
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AVALIAÇÃO DA ATIVIDADE ANTILEISHMANIA DA PLA2 Lys49 MjTX-I, ISOLADA DA PEÇONHA DE Bothrops moojeni
Leishmaniasis is a disease caused by protozoa of the genus Leishmania. The currently available treatment presents high toxicity, high cost, parasite resistance and difficulties in cure. In this sense, snake venoms are a promising source of study, since they have a series of bioactive compounds with …
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Neutrophil interactions with Leishmania amastigotes: implications for chronic leishmaniasis
Leishmaniasis is a neglected tropical disease responsible for considerable morbidity and mortality in the developing world. The immune response against Leishmania parasites must be fine-tuned to promote pathogen clearance without triggering excess inflammation, and this requires the concerted …
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Characterization of the effects of Interferon gamma protein-10 (CXCL10) against the protozoan parasite Leishmania amazonesis
Leishmania amazonensis causes progressive disease in most inbred strains of mice. We have previously shown that L. amazonensis-infected C57BL/6 mice have profound impairments in expression of pro-inflammatory cytokines, chemokines and in activation of antigen-specific CD4+ T cells. These …
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Síntese e avaliação das atividades leishmanicida, citotóxica, fungicida e inseticida de derivados da vanilina contendo o núcleo 1,2,3- triazólico e obtenção de novos derivados 1,2,3-triazólicos do eugenol
… dos derivados triazólicos da vanilina contra Leishmania amazonensis mostrou que o composto 3- metoxi-4-(3-(1-(4-nitrobenzil)-1H-1,2,3-triazol-4-il)propoxi)benzaldeído (7b) foi o mais ativo, apresentando valores de IC 50 iguais a 1,1 e 4,2 µmol L -1 contra as formas promastigotas e amastigotas, …