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Showing 1 to 20 of 134 for “"Leishmania"”.
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Identification of Leishmania tropica and Leishmania aethiopica by DNA sequencing and the detection of Leishmania RNA Virus
Leishmaniasis is a neglected tropical disease and a major cause of morbidity and mortality in impoverished countries. Leishmaniasis is a global disease and is clinically and epidemiologically diverse, with many different species of Leishmania affecting humans. The aim of this study was to …
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Immunity to Leishmania mexicana parasite
Background: Cutaneous Leishmaniasis caused by the Leishmania mexicana complex is associated with unpleasant or disfiguring lesions, for which there only limited treatment options. The life cycle of L. mexicana consists of two stages which involve different immune evasion mechanisms: promastigote …
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Studies on immunology of Leishmania mexicana
Leishmaniasis is a worldwide disease prevalent in many tropical and sub tropical countries. Treatment of Leishmaniasis by chemotherapy is not wholly effective and is usually accompanied by unpleasant side effects. The development of an effective and inexpensive vaccine represents a practical way to …
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Intracellular trafficking of Leishmania major peptidases
Leishmania resides inside mammalian macrophages, from where it is thought to manipulate the host immune system by releasing virulence factors. The cysteine peptidase CPB has been shown to be secreted by the parasite and act as such a virulence factor. CPB is released through the flagellar pocket …
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Regulators of autophagy in Leishmania major
… for life cycle progression and virulence of Leishmania. ATG8 is a ubiquitin like protein that is required for the formation of autophagosomes, and Leishmania uniquely possesses a set of ATG8-like proteins in addition to ATG8, that are distributed in three multi-gene families called ATG8A, …
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Lipoic acid metabolism in Leishmania major
Protozoan parasites of the genus Leishmania are the causative agents of a complex of diseases referred to as leishmaniasis. Leishmania have a digenetic life cycle that involves a sand fly vector (promastigote stage) and a mammalian host (amastigote stage). The parasites reside within very different …
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BIOMEDICAL, IMMUNOLOGICALS AND EPIDEMIOLOGICAL STUDIES ON LEISHMANIA
Riassunto della tesi Leishmania tarentolae è un protozoo non patogeno generalmente associato ai rettili, recentemente emerso come modello versatile nella ricerca biotecnologica e biomedica. È caratterizzato da un rapido tasso di crescita, bassi costi di mantenimento e può essere manipolato in …
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Studies using luciferase-expressing Leishmania donovani parasites
Visceral leishmaniasis is a life threatening illness that affects 12 million people worldwide and 350 million people across 88 countries are at risk of infection. The disease is caused by Leishmania donovani, a parasite transmitted by the female sand fly. Resistance to the drugs used to treat the …
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Interaction between Leishmania parasites and mammalian macrophages
Leishmania parasites are digenetic protozoans which infect human hosts and are causative agents of a series of diseases known under the name of leishmaniasis. Macrophages represent the main host. Hence the interaction between Leishmania and macrophages is a fundamental step in the development of …
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Studies on oligopeptidase B of Leishmania major
Peptidases of Leishmania are acknowledged virulence factors. It is hypothesised that peptidases are crucial for the survival of Leishmania in its hosts and that many could be potential targets for new antileishmanial drugs. As such, the investigation of peptidase activity in live Leishmania …
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Analysis of cyclin dependent kinases in Leishmania
… kinases and cyclins in the protozoan parasite Leishmania major. Cdks in kinetoplastids, CRKs, are the key regulators that allow cells to progress through different cell cycle phases and promote parasite proliferation during infection. In chapter 3 of this study, the results presented showed …
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Caracterização da resposta imunometabólica frente a infecção por Leishmania amazonensis e Leishmania braziliensis em macrófagos de camundongos BALB/C
INTRODUCTION: Leishmaniasis is a neglected tropical disease caused by protozoa of the genus Leishmania and represents a serious public health problem. These parasites infect cells of the innate immune system, particularly macrophages, and possess the ability to modulate cellular metabolism during …
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MONITORING OF LEISHMANIA TARENTOLAE AND LEISHMANIA INFANTUM IN SAND FLIES AND SYNANTHROPIC REPTILES OF NORTHERN ITALY: EMERGING EPIDEMIOLOGICAL SCENARIOS?
… and parasites. Among parasitic infections, leishmaniases, caused by protozoan parasites of the genus Leishmania, rank second only to malaria in terms of mortality. These parasites are transmitted to vertebrate hosts through the bites of infected sand flies (Diptera: Psychodidae: …
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Dendritic cell regulation of immunity to Leishmania donovani
… of chronic infection, is less fully described. Leishmania donovani is an intracellular protozoan parasite of mammalian phagocytes, capable of establishing a persistent and life-threatening infection in man. Associated with profound immunopathology and chronic immune suppression, visceral …
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Neutrophil interactions with Leishmania amastigotes: implications for chronic leishmaniasis
Leishmaniasis is a neglected tropical disease responsible for considerable morbidity and mortality in the developing world. The immune response against Leishmania parasites must be fine-tuned to promote pathogen clearance without triggering excess inflammation, and this requires the concerted …
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Regulation of innate immune responses to Leishmania braziliensis infection
Leishmania braziliensis (Lb) is a protozoan parasite, and the causative agent of cutaneous (CL) and mucocutaneous (ML) leishmaniasis in South America. ML is a severe and disfiguring form of the disease, usually compromising mucosal tissues within the nose, mouth and pharynx. In humans, ML is …
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Determining the substrates for MAP kinases in Leishmania mexicana
Leishmaniasis is a protozoan infection caused by Leishmania species, members of the parasitic trypanosomtidae family. Leishmania mexicana is a 'New World' species causing cutaneous leishmaniasis. Resistance to the current drug treatments has been observed for Leishmaniasis and with this resistance …
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Delayed-type hypersensitivity and cellular immunity to Leishmania donovani
Thesis (M.S.)--Michigan State University. Dept. of Microbiology and Public Health, 1970
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Molecular, biochemical and functional analysis of kinesins in Leishmania mexicana
Leishmaniasis is a vector-borne disease that is caused by several species of the obligate intra-cellular protozoan parasite Leishmania. Leishmaniasis is a tropical and sub-tropical disease affecting between (12 – 15) million people worldwide. An estimated 1.5 to 2 million new cases occur and it …
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Leishmania CRK3:CYC6 cyclin-dependent kinase as a drug target
Leishmania species are protozoan parasites which have a complex life cycle, which is coordinated with its cell cycle. There are 11 cyclin dependent kinases (CDKs) and 11 cyclins present in the Leishmania genome reflecting the complexity of cell cycle control in this parasite, perhaps due to the …
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