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Showing 1 to 15 of 15 for “"Leiomyoma"”.
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A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
Uterine Leiomyoma (UL), also known as Uterine Fibroids, are benign, hormone-sensitive tumors arising in the smooth muscle tissue layer of the uterus, the myometrium. UL are the most common female reproductive tract tumors, with lifetime occurrence in up to 77% of all women. A third of women with UL …
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Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone
Uterine leiomyomas are known as the most commonly occurring neoplasms in women during their reproductive years. The overall incidence of these benign tumors can be as high as 70-80%, which represents a significant health problem to women. Patients suffer from abnormal uterine bleeding, pelvic pain, …
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Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways
… components of the EGF and PDGF pathways in leiomyoma and normal myometrial SMCs. The main findings of this work were: 1) leiomyoma smooth muscle cells (LSMCs) and myometrial smooth muscle cells (MSMCs) produce ROS in response to EGF and PDGF; 2) ROS are necessary for EGF- and PDGF-induced …
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Phosphorylation of the Estrogen Receptor Alpha (ERα) at Serine 118 by Phospho-p44/42 MAPK and Regulation by Estrogen and Progesterone in Human Uterine Leiomyoma Tissue and Cells
<p>It is thought that the growth of uterine leiomyomas may be mediated by the interaction of estrogen receptor alpha (ERα) and growth factor pathways and that phosphorylation of ERα at serine 118 (ERα-phospho-Ser118) is important in this interaction. In tissue, immunoblotting and …
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Xenoestrogen-Specific Mechanisms of Developmental Reprogramming Correlate With Gene Expression and Tumor Development
… giving rise to complete penetrance of uterine leiomyoma. Based on this, we hypothesized that xenoestrogens, including genistein (GEN) and bisphenol A (BPA), reprogram estrogen-responsive gene expression in the myometrium and promote the development of uterine leiomyoma. We proposed the …
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Gimdos miomos. Klinikinio atvejo pristatymas ir literatūros apžvalga /
… in the uterine cavity, most similar to a uterine leiomyoma with cystic degeneration. Elective surgery was performed: laparoscopic total hysterectomy with bilateral salpingoovarectomy. The surgical specimen (uterus with appendages) was sent to the State Pathology Centre for examination, and …
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Role of Extracellular Signal-Regulated Kinase and Peroxisome Proliferator-Activated Receptor gamma on Transforming Growth Factor-β1-Induced Human Endometrial Stromal Cell Decidualization
… other than endometrial diseases such as leiomyoma. Endometrial stromal cells were cultured under the following conditions: DMEM/F-12 (10% FBS, 1 nM E2 and 100 nM P4). 5 ng/ml of TGF-β1, 50 nM of rosiglitazone (PPAR gamma agonist), and 20 μM of PD98059 (ERK inhibitor) were added according …
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Identifying and Targeting Molecular Deregulations In Uterine Leiomyosarcoma: A Role For Mtor Inhibition-Based Combination Therapies
… compared to GI smooth muscle, myometrium, and leiomyoma controls. Our results suggest that significant loss of smooth muscle and gynecological differentiation markers is common in ULMS, a finding that could help render improved ULMS diagnosis, especially for advanced disease. Similarly to …
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Neuroendocrine neoplasms of the digestive tract: retrospective classification according to the 2019 WHO grading system, and evaluation of the immunohistochemical marker INSM1
… gastrointestinal stromal tumour, lymphoma, leiomyoma and Kaposi sarcoma). Eighty percent of our NEN cases stained with INSM1. We found the sensitivity of INSM1 to be higher than CgA (68%), but lower than SYN (87%) and the combined use of CgA-SYN (94%) when considering all NENs. When …
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The Role of PRICKLE1 in the Regulation of Uterine Structure and Physiology
… Under pathological conditions, such as uterine leiomyoma (UL, uterine fibroids), myometrial cell and ECM deposition and organization are disrupted through fibrosis. Despite its importance, the mechanisms governing uterine cell organization, the impact of ECM organization, and uterine fibrosis …
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Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids
Uterine fibroids, also known as leiomyomas, are benign smooth muscle cell (SMC) tumors of the myometrium and are the most frequent reason for a hysterectomy. Although benign, these tumors pose a significant burden on patients with symptoms of abdominal pain, pressure, uterine bleeding, and …
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CLINICAL VALIDATION OF 371 MICRO-RNA USE IN SMALL TESTICULAR MASSES AND IN STAGE IIA AND IIB<3CM TESTICULAR GERM CELL TUMORS
… in Leydig cell tumors, 1 in burn-out tumor, 2 in leiomyoma and 16 in capillary hemangioma. The overall sensitivity is 88% and the overall specificity is 75%. 371a-p miRNA was tested in all small retroperitoneal disease patients before surgery and in 8 of 9 patients at thirty days. The proposed …
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Dietary intervention with whole flaxseed or vitamin D has beneficial effects on leiomyomas in the oviduct of the laying hen
Uterine leiomyomas, or fibroids, have a symptomatic incidence of around 40% and are a leading cause of reproductive morbidity in reproductively-aged women. Symptoms include menorrhagia, pelvic pain, and infertility. They are characterized by excessive production of extracellular matrix components, …
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Novel Effects of Simvastatin on Uterine Fibroids
Uterine fibroids (also known as leiomyomas) represent a common gynecologic problem with a significant medical and economic burden. Unfortunately, no satisfactory long-term medical treatment is currently available. Statins are drugs commonly used for the treatment of high plasma cholesterol levels. …
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Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology
Endometrial adenocarcinoma and leiomyomas are prevalent disorders of the same organ. Endometrial cancer, the most prevalently diagnosed gynecological cancer, is associated with mutated PTEN tumor suppressor gene. The type I endometrial cancer PTEN hotspot mutation involves a cytosine to guanine …