Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Legumain"”.
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Expression and analysis of a legumain from trichomonas vaginalis
… study explores the expression of one particular legumain-like cysteine protease known as Tv AE 1. Furthermore, it highlights the relationship between inhibitory effects of trichomonal cells caused by sanguinarine and chelerythrine. A system for obtaining legumains by expressing it in …
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Untersuchungen zur Struktur und Funktion des Legumain-Gens im Modellsystem Maus
Untersuchungen zur Struktur und Funktion des Legumain-Gens im Modellsystem Maus <br> <br>Die Asparaginyl-Endopeptidase Legumain gehört zu den Cystein-Peptidasen und ist im Lysosomen aktiv. Zur Zeit ist sie der einzige Vertreter in der Peptidasefamilie C13 der Säuger. Ursprünglich wurde Legumain in …
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The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque.
… designed to be substrate specific for either legumain or MMP-2/9 were synthesized. This was achieved via a combination of both solid and solution phase peptide synthesis. The first phase of the research study focused on the synthesis of a targeted MRI contrast agent designed to image legumain …
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Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor
… to be the lysosomal cysteine cathepsins and legumain. Cystatin C has been considered to excert its enzyme inhibiting functions extracellularly, as a defense against enzymes from leaking lysosomes or invading pathogens. It was demonstrated by various techniques, including flow cytometry, …
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Characterisation of oncogenic pathways driving the pathogenesis of prostate cancer
… cancer (PCa) progression and metastasis. Legumain (LGMN), an asparaginyl endopeptidase, is highly expressed in PCa and correlates with poor prognosis. LGMN is vital to PCa cell viability and migration, shown through RNAi targeting and selective drug inhibition. HSD17B4 was identified as a …
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Proteomic Investigation of chickpea seeds: the case study of the Italian genotype Pascià [Analisi proteomica dei semi di cece (Cicer arietinum L.): il caso del genotipo italiano Pascià]
… la maturazione delle viciline è mediata dalle legumain, una famiglia di endopeptidasi cisteiniche. Inoltre, i dati ottenuti suggeriscono che, analogamente alle proglicinine della soia, il ponte disolfuro intercatena che collega le catene α e β possa coinvolgere la cisteina localizzata nella …
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Cistatinas de cebada: proteínas de defensa contra artrópodos
… inhibition of the cysteine proteases C13 of the legumain family. The tridimensional structures of the thirteen cystatins have been modelized from the crystalized structure of the oryzacystatin I from rice. Expression patterns obtained from RT-qPCR have indicated that barley cystatins are …