Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Legionnaires' disease"”.
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Implementation of molecular techniques in the diagnosis of legionnaires’ disease and in the investigation of legionella outbreaks
Background. Legionnaires’ Disease (LD) is a mild to severe, potentially lethal, respiratory syndrome caused by members of the Legionella genus, in particular L. pneumophila serogroup (sg) 1 alone causes about 95% of culture confirmed cases. The infection is usually acquired by inhalation of …
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Legionella infections : a review of the literature and a prospective serological study of the incidence of Legionnaires disease at Groote Schuur Hospital
A prospective study of patients with pneumonia admitted to Groote Schuur Hospital took place over a one-year period in an attempt to assess the incidence of legionella pneumonia. Acute and convalescent serum samples were obtained from 113 patients. Eight patients (7,1%) showed a fourfold rise in …
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Proteomic and genomic characterization of the influence of copper on Legionella pneumophila and the drinking water microbiome
… and cause a deadly form of pneumonia known as Legionnaires' disease. Given that it is one of the primary sources of tap-water associated disease throughout much of the world, this organism has been the subject of intense research, ranging from aiming to understand key aspects of its physiology …
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Legionella pneumophila in Domestic Hot Water Systems: Evaluation of Detection Methods and Environmental Factors Affecting Survival
Legionella is the causative agent of Legionnaires' disease which hospitalizes 8,000 to 18,000 people in the United States each year. The disease in transmitted through inhalation or aspiration of water containing the bacterium and can be acquired within the home. Studies have found that 0-37% of …
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Environmental regulation of the growth, physiology and virulence of <i>Legionella pneumophila</i>
… man; the most severe, pneumonic form is known as Legionnaires' disease. Of the 39 species described to date 16 have been associated with human disease, however the majority of reported cases of legionellosis are caused by <i>Legionella pneumophila</i> serogroup 1. A number of pathogenic bacteria …
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Host cell death in Legionella pneumophila pathogenesis and immunity
… that causes a severe, atypical pneumonia termed Legionnaires' disease. Upon entering the host cell, <em>L. pneumophila</em> resides in a membrane-bound vacuole, in which the bacterium evades lysosomal fusion and replicates. The establishment of the vacuole requires the Dot/Icm (Defect in …
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DEVELOPMENT OF A RAPID DIAGNOSTIC ASSAY FOR THE COLORIMETRIC DETECTION OF LEGIONELLA BACTERIA USING LOOP MEDIATED ISOTHERMAL AMPLIFICATION
… droplets carrying <em>Legionella </em>can cause Legionnaires’ disease, a rapidly progressing pneumonia. From 2000-2016 the number of Legionnaires’ cases increased 5-fold. Detecting <em>Legionella </em>in water systems can be challenging. <em>Legionella </em>have complex growth requirements, …
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Impact of Premise Plumbing Conditions, Materials, Corrosion Control, Temperature, and Water Heater System Design on the Growth of Opportunistic Pathogens in Drinking Water
As waterborne disease originating in potable water plumbing systems (such as Legionnaires' Disease and Nontuberculous Mycobacterial (NTM) infections) continue to increase, it is important to better understand the cause(s), responsible parties and interventions to prevent disease. This dissertation …
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Virulence and pathogenic mechanisms of <i>Legionella pneumophila</i>
… or CV and it was suggested that progression of disease and cause of death was not typical of Legionnaires' disease. <br></br><br></br>An immunocompromised mouse model of Legionnaires' disease was investigated using aerosol infection of severe combined immune deficient (SeID) mice. SCID mice did …
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Study of the Yeast Vacuolar-type ATPase by Electron Cryomicroscopy
… Legionella pneumophila, the causative agent of Legionnaires' Disease, secretes a protein effector called SidK that binds and inhibits V-ATPases, preventing acidification of lysosomes and promoting survival of the bacterium inside macrophages. The mechanism of V-ATPase inhibition by SidK is not …
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Occurrence and Control of Microbial Contaminants of Emerging Concern through the Urban Water Cycle: Molecular Profiling of Opportunistic Pathogens and Antibiotic Resistance
… organism and likely triggered one of the largest Legionnaires' Disease outbreaks in U.S. history.
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The colonisation of treated water systems by <i>Legionella pneumophila</i>
… from a calorifier responsible for an outbreak of Legionnaires' disease and contained virulent <i>L. pneumophila</i>a serogroup 1 along with associated microorganisms including protozoa. The model system was supplied with filter sterilised tap water as the sole nutrient source for the growth of the …
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Assessing the Potential of Granular Activated Carbon Filters to Limit Pathogen Growth in Drinking Water Plumbing Through Probiotic Versus Prebiotic Mechanisms
… showering. The resulting respiratory illnesses, Legionnaires’ Disease and NTM lung disease, are among the leading sources of drinking water associated disease in the United States and other parts of the world. Lp and NTM are both difficult to control, because they establish as part of natural …
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Optimización del diseño higiénico de los sistemas frigoríficos. Análisis del caso de los condensadores evaporativos
[SPA] Los sistemas frigoríficos están presentes, en mayor o menor medida, en un amplio rango de campos tales como la producción y conservación de alimentos, la climatización de edificios, la industria química, la medicina o el transporte de mercancías perecederas. Una de las aplicaciones más …